meropenem and Hematoma

An infected cephalhematoma is a rare condition in neonates. We report a case of an 18-day-old neonate who was diagnosed with an infected cephalhematoma caused by an extended spectrum beta-lactamase (ESBL)-producing Escherichia coli complicated with septicemia, meningitis, and skull osteomyelitis. He was successfully treated with meropenem and surgical incision and drainage. ESBL-producing E. coli may cause infection of a cephalhematoma in neonates.

Topics: Anti-Bacterial Agents; beta-Lactamases; Drainage; Escherichia coli; Hematoma; Humans; Infant, Newborn; Male; Meningitis, Escherichia coli; Meropenem; Osteomyelitis; Sepsis; Skull; Thienamycins

Brain abscess formation is a rare complication of intracranial endovascular treatment. To our knowledge, all previous reports of brain abscess formation have been associated with treatments involving the introduction of foreign materials. A 75-year-old man was admitted to hospital for acute stroke. Cerebral angiography revealed occlusion of the left middle cerebral artery (MCA) at the origin of the M2 segment. Intra-arterial thrombolytic therapy was administered but a hemorrhagic event occurred during this process. A brain CT scan revealed a hematoma extending from the left basal ganglia to the left frontal lobe and expansion of the infarct in the left MCA territory. A brain abscess at the hemorrhagic site developed 3 months after symptom onset. This is the first report of a patient with brain abscess formation following intra-arterial thrombolytic treatment. It is important to ensure aseptic technique during endovascular procedures irrespective of the involvement of foreign materials.

Topics: Aged; Anti-Infective Agents; Brain Abscess; Brain Ischemia; Cerebral Angiography; Cerebral Hemorrhage; Endovascular Procedures; Fibrinolytic Agents; Hematoma; Humans; Male; Meropenem; Thienamycins; Thrombolytic Therapy; Tomography, X-Ray Computed; Urokinase-Type Plasminogen Activator