meropenem and Flavobacteriaceae-Infections

Topics: Aged; Amikacin; Anti-Bacterial Agents; Chryseobacterium; Drug Therapy, Combination; Flavobacteriaceae Infections; Humans; Male; Meropenem; Rifampin; Shock, Septic; Tigecycline; Trimethoprim, Sulfamethoxazole Drug Combination

A new natural IND-type metallo-beta-lactamase variant, IND-5, was identified in a clinical isolate of Chryseobacterium indologenes. IND-5 shared 92.8% and 92.4% amino acid homology with IND-1 and IND-3, respectively. Purified enzyme (pI = 8.8, M(r) = 25,000) was able to hydrolyze penicillins, some narrow- and expanded-spectrum cephalosporins, and carbapenems but not monobactams.

Topics: Amino Acid Sequence; Anti-Bacterial Agents; beta-Lactam Resistance; beta-Lactamases; Carbapenems; Cephalosporins; Chryseobacterium; Flavobacteriaceae Infections; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Penicillins; Sequence Analysis, DNA

Chryseobacterium meningosepticum is a lactose-nonfermenting gram-negative bacilli ubiquitously found in the natural and hospital environment. Clinical infection caused by C. meningosepticum is very rare among healthy adults. We present the case of a patient with end-stage renal disease who developed purulent pericarditis with C. meningosepticum infection, which rapidly evolved into cardiac tamponade and death. To our knowledge, this is the first case in which C. meningosepticum caused fatal purulent pericarditis in a hemodialysis patient.

Topics: Aged; Anti-Bacterial Agents; Cardiac Tamponade; Chryseobacterium; Ciprofloxacin; Fatal Outcome; Flavobacteriaceae Infections; Humans; Kidney Failure, Chronic; Male; Meropenem; Pericarditis; Renal Dialysis; Thienamycins; Vancomycin