meropenem and Corneal-Ulcer

To describe the first known case of Bacteroides spp. related blebitis, keratitis, and endophthalmitis following uncomplicated trabeculectomy.. This was a case report and literature review.. A 63-year-old immunocompetent white male underwent uncomplicated trabeculectomy of his right eye. Two weeks later, a blebitis with adjacent keratitis was diagnosed, progressing over several days to endophthalmitis despite hourly topical fortified antibiotic therapy. Although gram stain and culture of the bleb surface, a conjunctival suture, the aqueous humor, and the vitreous were negative, topical real-time quantitative polymerase chain reaction testing disclosed the presence of Bacteroides spp. Following treatment with topical and intravitreal clindamycin and intravenous meropenem, all clinical evidence of infection resolved. Best spectacle-corrected visual acuity improved to 20/25 (0.8) subsequent to combined cataract extraction, intraocular lens implantation, and pars plana vitrectomy for persistent vitreous debris.. Bacteroides may be a rare cause of postoperative blebitis, keratitis, and endophthalmitis. A favorable outcome may be attained, provided that an accurate diagnosis and effective treatment can be provided, which may be facilitated by real-time quantitative polymerase chain reaction in select cases.

Topics: Administration, Ophthalmic; Anti-Bacterial Agents; Bacteroides; Bacteroides Infections; Clindamycin; Corneal Ulcer; Drug Therapy, Combination; Endophthalmitis; Eye Infections, Bacterial; Glaucoma, Open-Angle; Humans; Injections, Intravenous; Intravitreal Injections; Male; Meropenem; Middle Aged; Real-Time Polymerase Chain Reaction; Trabeculectomy