meropenem and Arthritis

We report an unusual case of concurrent meningitis and infectious monoarthritis due to Listeria monocytogenes in a 65-year-old woman presenting to our department with a transient gastrointestinal tract illness. During hospitalization the patient's neurological status deteriorated, presenting signs of meningeal irritation along with signs of inflammation and oedema of the right knee. Blood cultures and cultures of the cerebrospinal fluid and of the sinovial fluid aspirate showed growth of L. monocytogenes gram positive rods. The patient received a three-week course of intravenous meropenem with significant improvement. To the best of our knowledge this is the first case of concurrent listerial meningitis and arthritis in an immunocompetent patient. Despite the rarity of the disease in healthy individuals a high index of suspicion is required for unusual manifestations of listerial infections especially among high risk groups such as the elderly.

Topics: Aged; Anti-Bacterial Agents; Arthritis; Female; Humans; Immunocompetence; Listeria monocytogenes; Listeriosis; Meningitis, Listeria; Meropenem; Thienamycins; Treatment Outcome

Topics: Aged; Anti-Bacterial Agents; Arthritis; Body Fluids; Chromatography, High Pressure Liquid; Drug Carriers; Humans; Male; Meropenem; Polymethyl Methacrylate; Prosthesis-Related Infections; Thienamycins; Treatment Outcome