merocyanine-dye has been researched along with Graft-vs-Host-Disease* in 4 studies
2 review(s) available for merocyanine-dye and Graft-vs-Host-Disease
| Article | Year |
|---|---|
Phototherapy, photochemotherapy, and bone marrow transplantation.
Recent preclinical and clinical investigations indicate that phototherapy and photochemotherapy may have applications that go far beyond their "traditional" roles in the treatment of skin disorders, selected solid tumors, and neonatal hyperbilirubinemia. Bone marrow transplantation is one area that may benefit substantially from these new developments. This review focuses on new applications of phototherapy and photochemotherapy that pertain to the inactivation of tumor cells in autologous bone marrow grafts, the prevention and treatment of acute and chronic graft-versus-host disease, the prevention of transfusion-induced allosensitization and graft rejection, and the inactivation of pathogenic viruses and parasites in bone marrow grafts and blood products. Topics: Animals; Antiviral Agents; Blood; Bone Marrow Purging; Bone Marrow Transplantation; Graft Rejection; Graft vs Host Disease; Humans; Immunization; Infection Control; Mice; Neoplasms; Neoplastic Stem Cells; Photochemotherapy; Photosensitizing Agents; Phototherapy; Pyrimidinones; Radiation-Sensitizing Agents; Transfusion Reaction | 1993 |
Pharmacological purging of bone marrow with reference to autografting.
Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Etoposide; Graft vs Host Disease; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lysophosphatidylcholines; Methylprednisolone; Neoplasms, Experimental; Phospholipid Ethers; Pyrimidinones; Transplantation, Autologous; Transplantation, Isogeneic | 1986 |
2 trial(s) available for merocyanine-dye and Graft-vs-Host-Disease
| Article | Year |
|---|---|
Phototherapy, photochemotherapy, and bone marrow transplantation.
Recent preclinical and clinical investigations indicate that phototherapy and photochemotherapy may have applications that go far beyond their "traditional" roles in the treatment of skin disorders, selected solid tumors, and neonatal hyperbilirubinemia. Bone marrow transplantation is one area that may benefit substantially from these new developments. This review focuses on new applications of phototherapy and photochemotherapy that pertain to the inactivation of tumor cells in autologous bone marrow grafts, the prevention and treatment of acute and chronic graft-versus-host disease, the prevention of transfusion-induced allosensitization and graft rejection, and the inactivation of pathogenic viruses and parasites in bone marrow grafts and blood products. Topics: Animals; Antiviral Agents; Blood; Bone Marrow Purging; Bone Marrow Transplantation; Graft Rejection; Graft vs Host Disease; Humans; Immunization; Infection Control; Mice; Neoplasms; Neoplastic Stem Cells; Photochemotherapy; Photosensitizing Agents; Phototherapy; Pyrimidinones; Radiation-Sensitizing Agents; Transfusion Reaction | 1993 |
Pharmacological purging of bone marrow with reference to autografting.
Topics: Adolescent; Adult; Animals; Bleomycin; Bone Marrow; Bone Marrow Transplantation; Cell Separation; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Evaluation; Etoposide; Graft vs Host Disease; Hematopoietic Stem Cells; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lysophosphatidylcholines; Methylprednisolone; Neoplasms, Experimental; Phospholipid Ethers; Pyrimidinones; Transplantation, Autologous; Transplantation, Isogeneic | 1986 |
2 other study(ies) available for merocyanine-dye and Graft-vs-Host-Disease
| Article | Year |
|---|---|
Inhibitory effects of merocyanine 540-mediated photodynamic therapy on cellular immune functions: A role in the prophylaxis of graft-versus-host disease?
Merocyanine 540-mediated photodynamic therapy (MC540-PDT) has been used in clinical trials for the purging of autologous hematopoietic stem cell grafts. When the same combinations of dye and light were applied to human peripheral blood lymphocytes, a broad range of T- and B-cell functions were impaired, prompting speculations about a potential role of MC540-PDT in the prophylaxis of graft-versus-host disease (GVHD). We here report on the effects of MC540-PDT on in vitro functions of murine lymphocytes as well as a preliminary evaluation of MC540-PDT for the prevention of GVHD in murine models of allogeneic bone marrow transplantation. Mixed lymphocyte reactions, proliferative responses to lectins, interleukin-2 and lipopolysaccharide, T-cell-mediated lysis, and NK activity were all inhibited by moderate doses of MC540-PDT. Whether MC540-PDT reduced the incidence and/or the severity of GVHD in murine models of allogeneic hematopoietic stem cell transplantation depended on the composition of the mismatched grafts and the intensity of the preparative regimen. MC540-PDT was only beneficial (i.e. reduced the incidence and/or severity of GVHD) when the spleen cell content of grafts was low and/or the radiation dose of the preparative regimen was not myeloablative, and, therefore, may have encouraged mixed chimerism. Topics: Animals; B-Lymphocytes; Body Weight; Bone Marrow Cells; Bone Marrow Transplantation; Cell Proliferation; Cell Survival; Female; Graft vs Host Disease; Killer Cells, Natural; Light; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Photochemotherapy; Photosensitizing Agents; Pyrimidinones; T-Lymphocytes; Transplantation, Homologous | 2015 |
Merocyanine 540-mediated photosensitization of leukemia and solid tumor cells.
Topics: Animals; Bone Marrow Transplantation; Graft vs Host Disease; Hematopoietic Stem Cells; Humans; Leukemia; Light; Neoplasms; Pyrimidinones; Transplantation, Autologous | 1985 |