mercaptopurine and Wounds-and-Injuries

Pyoderma gangrenosum (PG) is a neutrophilic dermatosis often associated with inflammatory bowel disease (IBD). The literature has suggested that PG-IBD is usually associated with ulcerative colitis.. We reviewed the PG-IBD cases at the Mater Health Services' Adult Hospital in Brisbane between 1998 and 2009 through assessment of a comprehensive web database of IBD patients and verification of chart information of PG-IBD cases.. PG-IBD at Mater was associated with clinically mild colonic IBD, with erythema nodosum, and with female sex. All PG-IBD responded eventually to increased immunomodulatory therapy.. We discuss why PG-IBD is associated with clinically mild colonic IBD be it ulcerative colitis, Crohn's or indeterminate colitis.

Topics: Adult; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Cyclosporins; Female; Humans; Hydrocortisone; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prevalence; Pseudomonas aeruginosa; Pseudomonas Infections; Pyoderma Gangrenosum; Sex Factors; Wounds and Injuries