mercaptopurine and Virus-Diseases

Topics: Anatomy; Arthritis; Autoantibodies; Betamethasone; Dexamethasone; Dihydroxyphenylalanine; Epidemiology; Histoplasmosis; Hypersensitivity; Melanoma; Mercaptopurine; Oxyphenbutazone; p-Methoxy-N-methylphenethylamine; Phenothiazines; Physiology; Prednisolone; Prednisone; Sarcoidosis; Toxicology; Toxoplasmosis; Triamcinolone; Uvea; Uveitis; Virus Diseases

Topics: Clinical Trials as Topic; Complement Fixation Tests; Culture Techniques; Cytomegalovirus; Humans; Immune Tolerance; Immunosuppression Therapy; Mercaptopurine; Methotrexate; Multiple Sclerosis; Simplexvirus; Virus Diseases

Autoimmune hemolytic anaemia (AIHA) in childhood is associated with antibodies produced by the patient himself, which coat his red cells causing their hemolysis. Although in some cases no underlying disease could be found, in the majority of children a virus etiology is apparent. There are very few reports regarding the use of treatment with immunsuppressive agents and the possible benefit. The article reports one case of AIHA. The patient developed at age 6 months a prolonged chronic form of AIHA complicated by thrombopenic purpura. The recent knowledge about pathogenesis, clinical phenomena, serology and prognosis is discussed. Treatment with corticosteroids, azathioprine or cyclophosphamide failed to benefit. Splenectomy and 6-mercaptopurin therapy (3 months) resulted in a complete remission.

Topics: Anemia, Hemolytic, Autoimmune; Autoantibodies; Azathioprine; Chronic Disease; Cortisone; Cyclophosphamide; Humans; Infant; Male; Mercaptopurine; Splenectomy; Virus Diseases

Topics: Child; Cyclophosphamide; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prognosis; Virus Diseases

Infections in the immunosuppressed cancer patient are caused by a wide variety of bacteria, viruses, fungi, and protozoa; many of these in the normal individual are saprophytes but will cause disease in the immunosuppressed patient, often with treatment failure. Patterns of infection are recognized, and this should enable the physician to plan a meaningful course of action when infection occurs in the compromised host. Obviously, it would be much better to prevent rather than have to treat infection in these immunosuppressed patients. Ideally, in the future, it is hoped that drugs which have less suppressive effect on defense mechanisms will provide a partial solution to the problem of infection in the immunosuppressed patient.

Topics: Adrenal Cortex Hormones; Alkylating Agents; Antineoplastic Agents; Azathioprine; Bacteria; Bacterial Infections; Folic Acid Antagonists; Humans; Immunity, Cellular; Immunosuppression Therapy; Immunosuppressive Agents; Infections; Lymphocytes; Mercaptopurine; Mycoses; Neoplasms; Phagocytosis; Protozoan Infections; Virus Diseases

Topics: Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Cystitis; Drug Therapy, Combination; Female; Herpes Zoster; Herpesvirus 3, Human; Humans; Infant; Infections; Leukemia; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Pneumonia, Viral; Prednisone; Remission, Spontaneous; Skin Diseases; Vincristine; Viral Vaccines; Virus Diseases

Topics: Antineoplastic Agents; Azathioprine; Condylomata Acuminata; Fluorouracil; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Papilloma; Pemphigus; Precancerous Conditions; Psoriasis; Scleroderma, Systemic; Skin Diseases; Skin Neoplasms; Virus Diseases

Topics: Adrenalectomy; Anilides; Animals; Avoidance Learning; Leukemia, Experimental; Mercaptopurine; Mice; Rauscher Virus; Sound; Spleen; Stress, Physiological; Triethylenemelamine; Virus Diseases

Topics: Adolescent; Black People; Bone Marrow Examination; Busulfan; Child; Chromosome Aberrations; Cyclophosphamide; Drug Therapy; Genetics, Medical; Humans; Infant; Leukemia; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mortality; Pathology; Psychotherapy; Social Conditions; Statistics as Topic; Steroids; United Kingdom; Vincristine; Virus Diseases; White People