mercaptopurine and Uveitis--Anterior

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; Granulomatosis with Polyangiitis; Hepatitis; Humans; Immunosuppressive Agents; Liver Cirrhosis; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Mice; Mice, Inbred NZB; Multiple Sclerosis; Nephritis; Nephrosis; Nitrogen Mustard Compounds; Penicillins; Psoriasis; Uveitis, Anterior

Orbital myositis is an extremely rare extra-intestinal manifestation of Crohn's disease. Herein we describe a patient with self-limiting episodes of episcleritis and uveitis prior to the diagnosis of Crohn's disease, and subsequent development of recurrent orbital myositis with radiological features mimicking thyroid eye disease.

Topics: Adult; Crohn Disease; Diagnosis, Differential; Female; Glucocorticoids; Graves Disease; Humans; Immunosuppressive Agents; Magnetic Resonance Imaging; Mercaptopurine; Methylprednisolone; Oculomotor Muscles; Orbital Myositis; Recurrence; Scleritis; Tomography, X-Ray Computed; Uveitis, Anterior

Effectiveness of selected anti-inflammatory drugs on the experimental model of uveitis was evaluated. Studies on the biochemical parameters of inflammation in the aqueous humor and biomicroscopic evaluation of the clinical condition of the anterior chamber of the eye, carried out in the therapy course, allowed to establish the following order of the studied drugs, according to their therapeutical effectiveness (from the most effective): indomethacin greater than ibuprofen greater than hydrocortizone greater than 6-mercaptopurine.

Topics: Animals; Anti-Inflammatory Agents; Aqueous Humor; Disease Models, Animal; Female; Hydrocortisone; Ibuprofen; Indomethacin; Male; Mercaptopurine; Orosomucoid; Peptide Hydrolases; Prostaglandins; Proteins; Rabbits; Sialic Acids; Uveitis, Anterior

Topics: Adult; Chorioretinitis; Humans; Mercaptopurine; Middle Aged; Uveitis; Uveitis, Anterior