mercaptopurine and Staphylococcal-Infections

Topics: Adrenal Cortex Hormones; Age Factors; Anti-Bacterial Agents; Asparaginase; Blood Platelets; Blood Transfusion; Bone Marrow Cells; Cyclophosphamide; Cytarabine; Folic Acid Antagonists; Humans; Leukemia; Mercaptopurine; Metals; Methotrexate; Prognosis; Radioisotopes; Radiotherapy; Staphylococcal Infections; Steroids; Vincristine

Topics: Antimetabolites, Antineoplastic; Burkitt Lymphoma; Child; Humans; Male; Mercaptopurine; Methotrexate; Piperacillin; Pseudomonas Infections; Seizures; Sepsis; Staphylococcal Infections

A case of methicillin-resistant staphylococcal (MRSA) enterocolitis following combination chemotherapy for acute promyelocytic leukemia is presented. MRSA enterocolitis has characteristic clinical features of high fever, frequent vomiting and watery diarrhea, and its mortality rate is very high without a proper antibiotic therapy. When the patient with hematological malignancy has the above-mentioned clinical manifestations during antineoplastic chemotherapy, appropriate antibiotics for MRSA should be promptly begun before a bacteriological diagnosis.

Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Enterocolitis; Humans; Leukemia, Promyelocytic, Acute; Male; Mercaptopurine; Methicillin; Middle Aged; Penicillin Resistance; Prednisolone; Remission Induction; Staphylococcal Infections; Staphylococcus aureus

Topics: Adolescent; Adrenocorticotropic Hormone; Alpha-Globulins; Antibodies, Antinuclear; Antimetabolites; Azathioprine; Blood Protein Electrophoresis; Calcinosis; Child; Creatine; Dermatomyositis; Electromyography; Exercise Therapy; Female; Fluorescent Antibody Technique; Fructose-Bisphosphate Aldolase; Growth Disorders; Humans; Immunosuppression Therapy; L-Lactate Dehydrogenase; Male; Mercaptopurine; Methotrexate; Middle Aged; Muscles; Prednisone; Remission, Spontaneous; Staphylococcal Infections; Transaminases

Phagocytosis and bacterial capacity of peripheral blood leucocytes were studied in 49 children with acute lymphoblastic leukaemia. No impairment of phagocytic ability was found, but 36% of children in relapse and 25% in remission had varying degrees of diminished intracellular killing capacity of ingested Staphylococcus aureus. Serial values in the same individual were constant irrespective of drugs used or stage of the disease. There was a highly significant positive correlation between bactericidal capacity ratio and the number of episodes of infection per patient; there was no significant correlation with death from infection.

Topics: Adolescent; Blood Bactericidal Activity; Child; Child, Preschool; Cyclophosphamide; Female; Humans; Infant; Leukemia, Lymphoid; Leukocytes; Male; Mercaptopurine; Methotrexate; Phagocytosis; Prognosis; Remission, Spontaneous; Staphylococcal Infections; Vincristine

Topics: Acute Disease; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Agranulocytosis; Aspergillosis; Candidiasis; Cytarabine; Female; Humans; Leukemia; Male; Mercaptopurine; Methotrexate; Middle Aged; Mucormycosis; Nocardia Infections; Prednisone; Proteus Infections; Pseudomonas Infections; Sepsis; Staphylococcal Infections; Strongyloidiasis; Uracil; Vinblastine

Topics: Abscess; Anti-Bacterial Agents; Aspergillosis; Candidiasis; Clostridium; Electrocardiography; Escherichia coli Infections; Geriatrics; Heart Diseases; Humans; Klebsiella; Mechlorethamine; Mercaptopurine; Pathology; Proteus; Staphylococcal Infections; Statistics as Topic; Steroids; Streptococcal Infections; Surgical Procedures, Operative