mercaptopurine and Purpura--Thrombocytopenic

mercaptopurine has been researched along with Purpura--Thrombocytopenic* in 26 studies

Reviews

3 review(s) available for mercaptopurine and Purpura--Thrombocytopenic

Article	Year
Immunosuppressive therapy of idiopathic thrombocytopenic purpura. The Medical clinics of North America, 1976, Volume: 60, Issue:5 The autoimmune nature of idiopathic thrombocytopenic purpura, as currently defined, is well established. Manipulations of the immune apparatus aimed at abating this deviant immunologic state may be one mode of approach to the therapy of this disease. Several cytotoxic compounds are capable of inhibiting the primary and secondary immune response to experimentally injected antigens in animals and man. Their beneficial role in the treatment of an autoimmune lupus-like syndrome in NZB mice24 is well documented. In human autoimmune disease, efficacy of the drugs is still to be established. The mechanisms by which immunosuppressive agents effect therapeutic response, and, in particular, whether this action is linked to suppression of immune reactivity needs clarification. Although preliminary analysis of the efficacy of immunosuppressive drugs in idiopathic thrombocytopenic purpura is encouraging, their therapeutic role has not superseded that of conventional management with steroids and splenectomy. Carefully controlled randomized clinical trials are now necessary so that more rational use of these agents can be recommended in future reports. Topics: Azathioprine; Cyclophosphamide; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Mercaptopurine; Purpura, Thrombocytopenic; Remission, Spontaneous; Splenectomy; Vinblastine; Vincristine	1976
Idiopathic thrombocytopenic purpura. The Netherlands journal of medicine, 1974, Volume: 17, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Autoimmune Diseases; Azathioprine; Blood Platelets; Blood Transfusion; Cell Survival; Child; Cyclophosphamide; Female; Humans; Infant, Newborn; Kinetics; Male; Mercaptopurine; Prednisone; Pregnancy; Purpura, Thrombocytopenic; Splenectomy; Thioguanine	1974
Immunosuppressive therapy. 1. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Blood Coagulation Disorders; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Dermatomyositis; Factor VIII; Hepatitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Prednisolone; Purpura, Thrombocytopenic; Scleroderma, Systemic	1972

Trials

1 trial(s) available for mercaptopurine and Purpura--Thrombocytopenic

Article	Year
Immunosuppressive therapy. 1. The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5 Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Blood Coagulation Disorders; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Dermatomyositis; Factor VIII; Hepatitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Prednisolone; Purpura, Thrombocytopenic; Scleroderma, Systemic	1972

Article

Year

Immunosuppressive therapy. 1.

The New England journal of medicine, 1972, Aug-03, Volume: 287, Issue:5

Topics: Alkylating Agents; Anemia, Hemolytic, Autoimmune; Antibodies; Antimetabolites; Arthritis, Rheumatoid; Azathioprine; Blood Coagulation Disorders; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cyclophosphamide; Dermatomyositis; Factor VIII; Hepatitis; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Prednisolone; Purpura, Thrombocytopenic; Scleroderma, Systemic

1972

Other Studies

23 other study(ies) available for mercaptopurine and Purpura--Thrombocytopenic

Article	Year
A case of Evans syndrome, successfully treated with 6-mercaptopurine. Yonsei medical journal, 1986, Volume: 27, Issue:2 Topics: Anemia, Hemolytic, Autoimmune; Child; Humans; Male; Mercaptopurine; Purpura, Thrombocytopenic; Syndrome	1986
Immunosuppressive therapy of chronic idiopathic thrombocytopenic purpura. The American journal of medicine, 1974, Volume: 56, Issue:1 Topics: Adolescent; Adult; Aged; Azathioprine; Blood Cell Count; Blood Platelets; Chronic Disease; Cyclophosphamide; Female; Follow-Up Studies; Humans; Immunosuppression Therapy; Male; Mercaptopurine; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Sex Factors; Splenectomy; Thioguanine	1974
[Immunosuppressive non-steroid therapy in thirteen cases of peripheral thrombocytopenic purpura (author's transl)]. Sangre, 1974, Volume: 19, Issue:1 Topics: Azathioprine; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Immunotherapy; Male; Mercaptopurine; Purpura, Thrombocytopenic	1974
Immunosuppressive therapy. The American journal of the medical sciences, 1973, Volume: 265, Issue:2 Topics: Anemia, Hemolytic, Autoimmune; Antigen-Antibody Reactions; Arthritis, Rheumatoid; Azathioprine; Crohn Disease; Cyclophosphamide; Female; Glomerulonephritis; Glucocorticoids; Hepatitis; Humans; Immunity; Immunity, Cellular; Immunosuppression Therapy; Immunosuppressive Agents; Male; Mercaptopurine; Methotrexate; Nephrotic Syndrome; Purpura, Thrombocytopenic	1973
[Problems in Evan's syndrome. Clinical and nuclear medicine studies]. Deutsche medizinische Wochenschrift (1946), 1973, Jun-08, Volume: 98, Issue:23 Topics: Adult; Anemia, Hemolytic, Autoimmune; Chromium Isotopes; Coombs Test; Cortisone; Female; Humans; Leukopenia; Male; Mercaptopurine; Middle Aged; Purpura, Thrombocytopenic; Splenectomy; Syndrome	1973
[Immunosuppressive cytostatic therapy in idiopathic thrombocytopenic purpura]. Acta medica Iugoslavica, 1973, Volume: 27, Issue:4 Topics: Adolescent; Adult; Aged; Azathioprine; Chlorambucil; Female; Humans; Mercaptopurine; Middle Aged; Purpura, Thrombocytopenic	1973
Immunosuppressive agents in the treatment of chronic idiopathic thrombocytopenic purpura. Paediatrica Indonesiana, 1973, Volume: 13, Issue:3 Topics: Antibodies; Azathioprine; Blood Platelets; Busulfan; Child; Child, Preschool; Chronic Disease; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Prednisone; Purpura, Thrombocytopenic	1973
[Immunosuppressive long-term therapy of autoimmune diseases in hematology]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Jun-01, Volume: 27, Issue:11 Topics: Adolescent; Adult; Aged; Anemia, Hemolytic, Autoimmune; Antimetabolites; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Female; Humans; Immunosuppressive Agents; Long-Term Care; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Middle Aged; Purpura, Thrombocytopenic	1972
[Varicella in antimetabolite and corticosteroid therapy]. Monatsschrift fur Kinderheilkunde, 1971, Volume: 119, Issue:5 Topics: Acute Disease; Adrenal Cortex Hormones; Blood Transfusion; Chickenpox; Child; Female; gamma-Globulins; Humans; Leukemia; Mercaptopurine; Prednisolone; Purpura, Thrombocytopenic	1971
[Immunosuppressive agents in hematology]. Munchener medizinische Wochenschrift (1950), 1970, Mar-20, Volume: 112, Issue:12 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Agranulocytosis; Anemia, Hemolytic, Autoimmune; Azathioprine; Child; Child, Preschool; Female; Hematologic Diseases; Humans; Immunosuppressive Agents; Infant; Infant, Newborn; Male; Mercaptopurine; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia	1970
[Immunosuppressive agents in hematology]. Minerva medica, 1970, Jul-11, Volume: 61, Issue:55 Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Agranulocytosis; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Azathioprine; Child; Child, Preschool; Female; Humans; Immunosuppressive Agents; Infant; Male; Mercaptopurine; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia	1970
[Experience in the therapy of autoimmune diseases]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1969, Aug-15, Volume: 24, Issue:16 Topics: Adolescent; Adult; Aged; Anemia, Hemolytic, Autoimmune; Autoimmune Diseases; Dactinomycin; Female; Granuloma, Lethal Midline; Humans; Male; Mercaptopurine; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Thrombocytopenia	1969
Lymphocyte transformation tests in patients under treatment with immunosuppressive drugs. Helvetica medica acta, 1969, Volume: 35, Issue:2 Topics: Adolescent; Adult; Aged; Anemia, Hemolytic, Autoimmune; Arthritis, Rheumatoid; Azathioprine; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Lectins; Lupus Erythematosus, Systemic; Lymphocyte Activation; Lymphocytes; Male; Mercaptopurine; Middle Aged; Purpura, Thrombocytopenic; Streptolysins	1969
[Effect of 6-mercaptopurine on the fibrinolytic activity of blood]. Problemy gematologii i perelivaniia krovi, 1968, Volume: 13, Issue:1 Topics: Animals; Female; Fibrinolysis; Humans; Male; Mercaptopurine; Purpura, Thrombocytopenic; Rabbits	1968
[The immunosuppressive agents. 3. The immunosuppressive agents in hematology]. La Presse medicale, 1967, Jul-01, Volume: 75, Issue:32 Topics: Anemia, Hemolytic, Autoimmune; Autoimmune Diseases; Azathioprine; Cyclophosphamide; Humans; Immunosuppressive Agents; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Nitrogen Mustard Compounds; Purpura, Thrombocytopenic; Thioguanine	1967
[The use of 6-mercaptopurine in the treatment of the immune form of Werlhof's disease]. Problemy gematologii i perelivaniia krovi, 1966, Volume: 11, Issue:4 Topics: Adolescent; Adult; Aged; Chronic Disease; Humans; Mercaptopurine; Middle Aged; Purpura, Thrombocytopenic	1966
[Therapeutic results in 45 cases of apparently extra-globular, acquired hemolytic anemia]. Minerva medica, 1966, Oct-20, Volume: 57, Issue:84 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anemia, Hemolytic, Autoimmune; Blood Transfusion; Humans; Mercaptopurine; Purpura, Thrombocytopenic; Splenectomy; Thioguanine	1966
IDIOPATHIC THROMBOCYTOPENIC PURPURA. Journal of the South Carolina Medical Association, 1965, Volume: 61 Topics: Adrenal Cortex Hormones; Drug Therapy; Humans; Mercaptopurine; Purpura; Purpura, Thrombocytopenic; Purpura, Thrombocytopenic, Idiopathic; Radiography; Splenectomy	1965
INFLUENCE OF NUCLEATED CELLS ON SICKLING PHENOMENON. Journal of the Indian Medical Association, 1964, Feb-01, Volume: 42 Topics: Anemia, Sickle Cell; Eosinophilia; Erythrocytes; Humans; Kwashiorkor; Leukemia; Leukemia, Lymphoid; Leukocytes; Mercaptopurine; Methotrexate; Oxidation-Reduction; Polycythemia Vera; Prednisolone; Purpura; Purpura, Thrombocytopenic; Reticulocytes; Thalassemia	1964
[ETIOLOGY, CLINICAL SIGNS AND DEVELOPMENT OF IDIOPATHIC THROMBOPENIC PURPURAS]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, Jan-26, Volume: 40 Topics: Adolescent; Adrenal Cortex Hormones; Child; Humans; Infant; Infant, Newborn; Mercaptopurine; Physiology; Purpura; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia	1964
[TREATMENT OF IDIOPATHIC THROMBOPENIC PURPURA]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1964, Feb-08, Volume: 40 Topics: Animals; Gastropoda; Humans; Mercaptopurine; Prednisone; Purpura; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia	1964
[EVOLUTION AND TREATMENT OF IDIOPATHIC THROMBOPENIC PURPURAS]. Studii si cercetari de medicina interna, 1964, Volume: 16 Topics: Adrenal Cortex Hormones; Humans; Mercaptopurine; Purpura; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia	1964
[CLINICAL COURSE AND TREATMENT OF IDIOPATHIC THROMBOPENIC PURPURA]. Acta haematologica, 1964, Volume: 31 Topics: Adrenal Cortex Hormones; Chromium Isotopes; Drug Therapy; Hemagglutination; Humans; Mercaptopurine; Prednisone; Purpura; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia	1964