mercaptopurine and Pulmonary-Embolism

Diffuse alveolar hemorrhage is an uncommon and often fatal condition in children that is characterized by distinct histopathological etiologies. Herein, we discuss the case of an 11-year-old girl who presented with acute worsening of hypoxia and left-sided chest pain. The patient had lung biopsy-proven idiopathic pulmonary capillaritis and was being treated with prednisolone every alternate day, azathioprine, and hydroxychloroquine. A contrast-computed tomography (CT) scan of the chest showed an acute left lower-lobe pulmonary embolism. Negative results were obtained on a test for thrombophilia. In children, pulmonary embolism with anti-neutrophil cytoplasmic antibody-negative idiopathic pulmonary capillaritis is a rare clinical condition. The exact cause of thrombus formation in this case is unknown; however, obesity, immobility, and chronic systemic corticosteroid therapy probably played a role.

Topics: Acute Disease; Antibodies, Antineutrophil Cytoplasmic; Capillaries; Chest Pain; Child; Female; Hemorrhage; Heparin, Low-Molecular-Weight; Humans; Hydroxychloroquine; Hypoxia; Lung; Lung Diseases; Mercaptopurine; Prednisolone; Pulmonary Alveoli; Pulmonary Embolism; Treatment Outcome; Vasculitis

Topics: Adult; Angiography; Choriocarcinoma; Dactinomycin; Female; Humans; Iliac Vein; Mercaptopurine; Phlebography; Pregnancy; Pulmonary Artery; Pulmonary Embolism; Radionuclide Imaging; Uterine Neoplasms; Vena Cava, Inferior

Topics: Aged; Autopsy; Humans; Leukemia, Myeloid, Acute; Leukocyte Count; Leukocytes; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Pulmonary Artery; Pulmonary Circulation; Pulmonary Embolism; Pulmonary Veins; Vincristine

Topics: Embolectomy; Glomerulonephritis; Heart, Artificial; Imidazoles; Kidney Function Tests; Kidney Transplantation; Mercaptopurine; Postoperative Complications; Prednisone; Pulmonary Embolism; Transplantation, Homologous; Vascular Surgical Procedures