mercaptopurine and Osteomyelitis

Pyoderma gangrenosum is a rare ulcerative skin disorder mainly occurring in adults. It is seen less frequently in children. The cause is unknown but it may occur in association with several disorders. Osteomyelitis is a very rare association. We report a case of pyoderma gangrenosum associated with osteomyelitis in a two-year-old girl.

Topics: Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Female; Humans; Mercaptopurine; Osteomyelitis; Prednisone; Pyoderma Gangrenosum; Sulfasalazine

In patients with Crohn's disease arthritis of the large joints, osteomalacia, osteoporosis and aseptic bone necrosis as a consequence of malabsorption and glucocorticoid intake may occur. The case of a patient with long-standing Crohn's disease is presented who subsequently developed abacterial osteomyelitis of the jaw ("osteomyelitis sicca"). The symptoms of the osteomyelitis improved under immuno-suppressive therapy. Because the etiopathogenetic concepts for Crohn's disease and osteomyelitis sicca are similar, the latter could be a rare extraintestinal manifestation in Crohn's disease, not described previously.

Topics: Adult; Combined Modality Therapy; Crohn Disease; Debridement; Diagnostic Imaging; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Male; Mandibular Diseases; Mercaptopurine; Methylprednisolone; Osteomyelitis

Topics: Aeromonas; Child; Female; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Osteomyelitis; Penicillin Resistance; Penicillins; Sepsis; Tetracycline