mercaptopurine and Nephritis

Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Chlorambucil; Cyclophosphamide; Granulomatosis with Polyangiitis; Hepatitis; Humans; Immunosuppressive Agents; Liver Cirrhosis; Lupus Erythematosus, Systemic; Mercaptopurine; Methotrexate; Mice; Mice, Inbred NZB; Multiple Sclerosis; Nephritis; Nephrosis; Nitrogen Mustard Compounds; Penicillins; Psoriasis; Uveitis, Anterior

Acute glomerulonephritis characterized by proteinuria, hypoalbuminemia and leukocytosis was induced in mice by repeated intraperitoneal injections of calf serum (1 ml/mouse X 10). In mice treated with calf serum, hypercellularity, karyorrhexis, expansion of the mesangium and hyalinosis in the glomeruli were observed by light microscopy. Furthermore, circulating immune complexes were detected in the serum, and deposits of mouse IgG and C3 on the basement membranes of the glomeruli were demonstrated immunohistochemically. Oral administration of cyclophosphamide or 6-mercaptopurine at a dose of 20 mg/kg/day significantly suppressed the development of this nephritis. Dexamethasone (0.5 mg/kg/day) caused moderate inhibition of the nephritic changes. These results suggest that this experimental model may be useful for evaluation of anti-nephritic drugs.

Topics: Animals; Anti-Inflammatory Agents; Blood Cell Count; Body Weight; Cyclophosphamide; Dexamethasone; Disease Models, Animal; Fluorescent Antibody Technique; Immunochemistry; Indomethacin; Kidney Glomerulus; Male; Mercaptopurine; Mice; Mice, Inbred ICR; Nephritis; Organ Size; Serum Sickness

Topics: Adolescent; Adult; Cyclophosphamide; Dipyridamole; Female; Heparin; Humans; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Middle Aged; Nephritis; Prednisolone

Topics: Adolescent; Adult; Antineoplastic Agents; Azathioprine; Chlorambucil; Chronic Disease; Cyclophosphamide; Female; Follow-Up Studies; Humans; Male; Mercaptopurine; Middle Aged; Nephritis; Remission, Spontaneous; Time Factors

Topics: Animals; Biopsy; Creatinine; Cyclophosphamide; Female; Freund's Adjuvant; Glomerular Filtration Rate; Immune Complex Diseases; Immune System Diseases; Kidney; Mercaptopurine; Methylprednisolone; Nephritis; Proteinuria; Rats; Tissue Extracts

Topics: Adolescent; Adult; Azathioprine; Basement Membrane; Biopsy; Chloroquine; Cyclophosphamide; Female; Follow-Up Studies; Glomerulonephritis; Glucocorticoids; Humans; Hyperplasia; Kidney Glomerulus; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Nephritis; Prednisolone

Topics: Adult; Antineoplastic Agents; Azathioprine; Dyspepsia; Female; Humans; Male; Mercaptopurine; Middle Aged; Nephritis; Nephrotic Syndrome

Topics: Aged; Humans; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Nephritis

Topics: Albuminuria; Chloroquine; Diuretics; Edema; Glomerulonephritis; Humans; Lupus Erythematosus, Discoid; Lupus Erythematosus, Systemic; Mercaptopurine; Nephritis; Nephrosis; Perinephritis; Prednisolone