mercaptopurine and Neoplasm-Metastasis

Trophoblastic tumors are among the rare diseases in this country. The most important clinical aspects are demonstrated by references and personal experiences in the treatment of trophoblastic tumors. In many countries (SU, USA, GB, Japan) the treatment of trophoblastic tumors has been centralized.--The therapeutical strategy is based on histology, stage and other important prognostic factors. Most important is chemotherapy with antineoplastic substances. Surgery and radiation are to be used only under appropriate indication. After treatment the control of the HCG-values by radioimmunassay is of high importance for the early diagnosis of relapse.--All facts demonstrate, that also in the GDR a stronger centralization of the treatment of trophoblastic tumors should be attained.

Topics: Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Drug Therapy, Combination; Female; Humans; Mercaptopurine; Methotrexate; Neoplasm Invasiveness; Neoplasm Metastasis; Pregnancy; Prognosis; Trophoblastic Neoplasms; Uterine Neoplasms

The authors review and discuss the basic concepts of cell kinetics as applied to brain tumors. Uncontrolled growth of a neoplasm represents an expanding tumor cell population. Four growth parameters characterize the behavior of a neoplastic population: cell cycle time, growth fraction, tumor doubling time, and cell loss. The concept of provisionally nondividing cells explains the disparity between cell cycle time and tumor doubling time. Human gliomas, like many non-neural solid tumors, contain variable proportions of actively proliferating and nonproliferating tumor cells; this ratio is expressed by the growth fraction. The major kinetic difference between glioblastomas and differentiated astrocytomas resides in their respective growth fractions, in all likelihood an inherent biological characteristic of each tumor. Glioblastoma proliferates at a rapid rate, and only a high rate of cell loss prevents this tumor from doubling its volume in less than 1 week. The selection of drugs and design of drug schedules for treatment of glioblastomas should be made with the knowledge that 60% to 70% of the cells in this tumor are resting (nonproliferating). If experience with other solid tumors is any guide, judicious selection and combined use of drugs according to kinetically sound schedules will produce more effective chemotherapy of brain tumors.

Topics: Alkylating Agents; Anti-Bacterial Agents; Antimetabolites; Astrocytoma; Brain; Brain Neoplasms; Cell Survival; DNA, Neoplasm; Glioma; Humans; Kinetics; Mercaptopurine; Mitosis; Neoplasm Metastasis; Prednisolone; Remission, Spontaneous; RNA, Neoplasm; Time Factors; Vincristine

Topics: Chemotherapy, Cancer, Regional Perfusion; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Female; Gonadal Steroid Hormones; Humans; Hysterectomy; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Ovarian Neoplasms; Postoperative Care; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms; Vinblastine

Topics: Adrenal Cortex Hormones; Alkylating Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Cytarabine; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Mercaptopurine; Methotrexate; Mitosis; Neoplasm Metastasis; Thymine Nucleotides

Topics: Asparaginase; Child; Cyclophosphamide; Cytarabine; Daunorubicin; Doxorubicin; Humans; Leukemia, Lymphoid; Male; Meninges; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisolone; Remission, Spontaneous; Testicular Neoplasms; Time Factors; Vincristine

Topics: Alkylating Agents; Aminopterin; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Diet; Female; Hormones, Ectopic; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Isoantigens; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Socioeconomic Factors; Testicular Neoplasms; Transplantation Immunology; Trophoblastic Neoplasms; Uterine Neoplasms; Vincristine

Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Clinical Trials as Topic; Cyclophosphamide; Drug Synergism; Female; Fluorouracil; History, 16th Century; Humans; Hydrazines; Injections, Intravenous; Laryngeal Neoplasms; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Prognosis; Time Factors; Tongue Neoplasms; Vinblastine

To systematic review the efficacy and safety of 6-thioguanine (6-TG) in the substitute of 6-mercaptopurine (6-MP) in the treatment for patients with childhood acute lymphoblastic leukemia (ALL) in the maintenance phase, and to explore its clinical application value. It provides theoretical guidance for the maintenance treatment of ALL in children from the perspective of evidence-based medicine.. By means of computer retrieval, Chinese databases were searched: Chinese Biomedical Database (CBM), China national knowledge internet (CNKI), Chongqing Weipu Database (VIP), and Wanfang Database; Foreign databases: PubMed, The Cochrane Library, Embase, and Web of Science were applied to find out randomized controlled trial (RCT) for 6-TG in childhood acute lymphoblastic leukemia. By manual retrieval, documents without electronic edition and related conference papers were retrieved. The retrieval time ranges from the beginning of the establishment of the databases to September 1st, 2019. According to the inclusion, and exclusion criteria by 3 researchers, the literature screening, data extraction, and research methodological quality evaluation were completed. RevMan 5.3 software was applied to evaluate the quality of the included literature, and Stata 12.0 software was used to conduct meta-analysis of the outcome indicators of the included literature.. This study systematically evaluated the efficacy and safety of 6-TG in the substitute of 6-MP as a maintenance drug for childhood acute lymphoblastic leukemia. Through the key outcome indicators, this study is expected to draw a scientific, practical conclusion for 6-TG in the treatment of childhood acute lymphoblastic leukemia. This conclusion will provide evidence-based medical direction for clinical treatment.. The efficacy and safety of 6-TG in the substitute of 6-MP in the maintenance treatment of childhood acute lymphoblastic leukemia will be confirmed through this study. The conclusions will be published in relevant academic journals.. PROSPERO (registration number is CRD42020150466).

Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Substitution; Humans; Infant; Mercaptopurine; Meta-Analysis as Topic; Neoplasm Metastasis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Randomized Controlled Trials as Topic; Recurrence; Research Design; Systematic Review as Topic; Thioguanine

Effects of the administration of gamma-(9H-purine-6-yl)thiomethyl L-glutamate (6-MPG), a water-soluble derivative of 6-mercaptopurine, on concomitant and sinecomitant immunity against the implanted MethA tumor were studied in BALB/c mice. In the concomitant immunity experiments, mice were intradermally inoculated with 1x10(5) MethA cells at the right inguinal region on day 0. In sinecomitant immunity experiments, mice were similarly inoculated on day -21, and the grown tumor was excised on day -11. Both the tumor-bearing and tumor-ectomized animals were re-inoculated with 3x10(6) MethA cells intradermally at the left inguinal region on day 10. Administration of 6-MPG (100 mg/kg, i.p.) on days 3 through 7 significantly inhibited growth of the re-inoculated tumor in both series of experiments. Cyclophosphamide, adriamycin, mitomycin C and cis-diamminedichloroplatinum (II) had no significant effect on the growth of the re-inoculated tumor in the tumor-ectomized mice. Spleen cells harvested from the 6-MPG-treated tumor-ectomized mice showed a strong tumor-neutralizing activity (Winn assay).

Topics: Animals; Antineoplastic Agents; Cell Transplantation; Immunity, Cellular; Male; Mercaptopurine; Methylcholanthrene; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Neutralization Tests; Phenotype; Spleen

A patient, a 46-year-old female, with a malignant thymoma spreading to the extrathoracic region is described. She underwent a thoracotomy and received radiation therapy, but the myasthenic symptoms did not disappear. A metastatic thymoma of the right mandibula was removed 9 months after thoracotomy. Further examination revealed metastatic thymomas of the bone and liver. After the operation the patient received combination chemotherapy (vincristine, cyclophosphamide, 6-mercaptopurine, prednisone) and remained asymptomatic for 31 months. She was found to have a metastatic thymoma in the occipital lobe of the brain 3.5 years after thoracotomy, and died from infection of the lung. Distant metastases and chemotherapy in malignant thymoma are reviewed.

Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Cyclophosphamide; Female; Humans; Liver Neoplasms; Mandibular Neoplasms; Mercaptopurine; Middle Aged; Neoplasm Metastasis; Prednisone; Thymoma; Thymus Neoplasms; Vincristine

We describe two adolescent girls with acute lymphoblastic leukemia (ALL) whose leukemia cells were near-haploid. Their lymphoblasts stained in a block pattern with periodic acid Schiff and had "common ALL" surface markers confirmed by indirect immunofluorescence. Each patient had two populations of blasts, one near-haploid and one hyperdiploid, which was an exact doubling of the near-haploid karyotype. The first patient had a predominant population of cells with 26 chromosomes and a few with 52, while the second had a predominance of cells with 56 and a minority with 28. Flow cytometric analysis of DNA content initially detected the minor near-haploid population in the second patient, which was confirmed later by cytogenetic review of the marrow sample. In addition to our two patients, only four patients have been reported with near-haploid ALL. Of these six, five were girls, five were adolescents, and five had short survivals (median, 10 mo). All six had disomy of chromosome 21 with or without disomy for chromosomes 10, 14, 18, or X (four patients each). Thus, near-haploid ALL may represent a unique subgroup of ALL with a poor prognosis. To detect these and other possible subgroups, we have included cytogenetic analysis and flow cytometric analysis of DNA content in our initial evaluation of patients with ALL.

Topics: Acute Disease; Adolescent; Bone Marrow Examination; Brain Neoplasms; Child; Daunorubicin; Female; Haploidy; Humans; Injections, Spinal; Karyotyping; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisone; Prognosis; Vincristine

Trophoblastic disease of pregnancy presents a continuous spectrum ranging from the non-invasive mole to the choriocarcinoma; modern chemotherapy has radically changed the prognosis of the latter. A pregnancy without mole was followed by choriocarcinoma with a high titer of chorionic gonadotrophin and vaginal, pelvic, and pulmonary metastasis, clinically apparent shortly after premature delivery. Neurologic phocality was manifested a few days before the onset of labour, and its relationship with the basic disease is discussed. A definitive cure was obtained by intermittent massive chemotherapy along with surgical resection of an isolated thyroid metastasis (a previously unreported location) and, posteriorly, of a pulmonary metastasis, both appearing during chemotherapy. The control of the therapeutic response by periodical monitoring of chorionic gonadotrophin levels is necessary in order to detect resistance to therapy and, eventually, to confirm definitive cure of the disease.

Topics: Adult; Antineoplastic Agents; Choriocarcinoma; Chorionic Gonadotropin; Cyclophosphamide; Dactinomycin; Drug Therapy, Combination; Female; Humans; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Pregnancy Complications; Uterine Neoplasms

A case of osteogenic sarcoma of the maxilla is described. The tumor was excised by a hemimaxillectomy but recurred in 3 months. The patient died 8 months after the initial onset of symptoms. Chemotherapy and radiation were ineffective with the exception of bleomycin, which caused necrosis of the tumour, with no apparent increase in growth, and a decrease of the serum alkaline phosphatase level to less than half of the maximum value. There was a close correlation between the fluctuating pattern of the serum alkaline phosphatase level and the growth and remission of the tumour during the entire course of treatment.

Topics: Alkaline Phosphatase; Bleomycin; Cyclophosphamide; Doxorubicin; Female; Humans; Maxillary Neoplasms; Mercaptopurine; Middle Aged; Mitomycins; Neoplasm Metastasis; Osteosarcoma; Prednisolone; Vincristine

The differential distribution of a series of antineoplastic agents in metastatic tissues compared to their respective primary tumors has been investigated in one rat and two mouse experimental tumor systems, ie, the intramuscular Lewis lung carcinoma (3LL) of C57BL/6 mice, which gives rise to spontaneous lung metastases, the intratibial Sarcoma 180 (S180) of CD1 mice, which induces macroscopic metastases to the lymph nodes, and the Walker 256 carcinosarcoma of CD rats, which also metastasizes to the lymph nodes. The results described in this paper show that the concentrations of adriamycin, daunorubicin, cyclophosphamide and its alkylating metabolites, hydroxyurea, 1-methyl-1-nitrosourea, and 6-mercaptopurine are much higher in the pulmonary metastases of 3LL and/or in the lymph node metastases of S180 than the concentrations measured in the primary tumor. In the Walker 256 tumor system the distribution of adriamycin appears to follow the same pattern observed for the mouse tumors. Only for methotrexate (in the 3LL tumor) is the difference in the concentrations at the two sites not so evident. These findings are discussed in relation to the comparatively greater sensitivity of metastases to chemotherapy.

Topics: Animals; Antineoplastic Agents; Bone Neoplasms; Carcinoma 256, Walker; Cyclophosphamide; Daunorubicin; Doxorubicin; Female; Hydroxyurea; Lung Neoplasms; Lymphatic Metastasis; Male; Mercaptopurine; Methotrexate; Methylnitrosourea; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Rats; Sarcoma, Experimental

Eighty-six children with non-Hodgkin's lymphoma were studied from 1964 to January 31, 1975. Seventy-six percent of the 43 patients in the nonprotocol group had far advanced disease, and 76% had Rappaport's diffuse histology. Only 11% of these patients survived free of disease. The second group of 43 patients received the LSA2L2 protocol. Seventy-six percent had advanced disease and 86% diffuse histology. Of these patients 76% are surviving free of disease with a median observation time of 25+ months. Fifty-one percent of the survivors are off therapy and without evidence of disease. Prognostic factors such as primary sites, stages, histology, and others are discussed. The most important prognostic factor is early and aggressive therapy, and the achievement of a complete response status within 1-2 months from onset of therapy.

Topics: Adolescent; Antineoplastic Agents; Asparaginase; Carmustine; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Drug Therapy, Combination; Female; Humans; Hydroxyurea; Lymphoma; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisone; Thioguanine; Vinblastine; Vincristine

Topics: Adolescent; Adult; Black People; Brain Neoplasms; Choriocarcinoma; Female; Humans; Jamaica; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Prognosis

Radioimmunoassays and bioassays based on the reactions of the native molecule of human chorionic gonadotropin (HCG) fail to differentiate HCG from pituitary luteinizing hormone (LH). An assay based on the beta-subunit of HCG which detects HCG exclusively has been used in our laboratory to monitor patients undergoing chemotherapy for gestational trophoblastic disease (GTD). We have been able to differentiate minimal, persisting tumor activity from normal levels of pituitary gonadotropins and have based therapy on these findings. Alternatively, treatment has been terminated when HCG is no longer detectable in the serum. Tumor activity has been detected in the beta-subunit assay at a time when biologic activity in the urine indicated remission.

Topics: Adult; Antineoplastic Agents; Biological Assay; Bleomycin; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Female; Follow-Up Studies; Humans; Hydatidiform Mole; Hydatidiform Mole, Invasive; Luteinizing Hormone; Mercaptopurine; Methotrexate; Monitoring, Physiologic; Neoplasm Metastasis; Pregnancy; Radioimmunoassay; Remission, Spontaneous; Trophoblastic Neoplasms

Topics: Acute Disease; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Female; Humans; Kidney Neoplasms; Leukemia, Lymphoid; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisone; Vincristine; Wilms Tumor

Topics: Bone Neoplasms; Child, Preschool; Cyclophosphamide; Female; Ganglioneuroma; Humans; Infant; Mercaptopurine; Neoplasm Metastasis; Neuroblastoma; Prednisone; Skin Neoplasms; Vincristine

The effect of hydrocortisone on blood-borne tumor metastasis was studied in an i.v. inoculation experiment with Ehrlich hypotetraploid clone 1, Ehrlich hypotetraploid stock, and Ehrlich hyperdiploid stock tumors. The administration of hydrocortisone before tumor inoculation resulted in increased tumor take, reduced mean survival time of mice, and concentration of tumor metastasis in a specific organ (i.e., lung metastasis for Ehrlich hypotetraploid clone 1 tumor, and liver metastasis for Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors). Enhancement of tumor metastasis, as induced by hydrocortisone pretreatment, was not reproduced by the administration of 6-mercaptopurine, testosterone, or estradiol. The progress of tumor death in hydrocortisone-conditioned mice was not affected by either heparin or dextran sulfate. This indicated that the effect of hydrocortisone on tumor metastasis was independent of the effect of these agents on immune reaction or blood coagulation. In the tracer experiment with 125-I-labeled tumor cells, hydrocortisone pretreatment significantly increased over the control the intrapulmonary retention of Ehrlich hypotetraploid clone 1 tumor cells from 1 through 72 hr after tumor inoculation, the time lag required for the establishment of metastatic foci in the lung. The arrest of Ehrlich hypotetraploid stock and Ehrlich hyperdiploid stock tumors in the liver was also temporarily increased by hydrocortisone pretreatment. No correlation was found between tumor cell size and differential distribution of metastatic tumors with 3 Ehrlich tumors. An attempt was made to use this blood-borne metastasis system for chemotherapeutic study. Administration of cyclophosphamide gave rise to a significant prolongation of survival time and often to complete prevention of tumor metastasis in hydrocortisone-conditioned mice.

Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cyclophosphamide; Dextrans; Estradiol; Female; Heparin; Hydrocortisone; Injections, Intravenous; Liver Neoplasms; Lung Neoplasms; Mercaptopurine; Mice; Mice, Inbred ICR; Neoplasm Metastasis; Neoplastic Cells, Circulating; Stimulation, Chemical; Testosterone; Time Factors

Topics: Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Immune Adherence Reaction; Immunosuppressive Agents; Melanoma; Menstruation; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisolone; Vincristine

Drug screening trials and general treatment of solid tumours in advanced cancer patients have been concerned only with the site of primary origin, regardless of where metastases might have seeded. Since the environment for tumour growth can differ appreciably at various anatomical sites, an investigation was undertaken to determine the effect of metastatic site on response to chemotherapy. Data from 1961 to 1965 of the screening trials of the Eastern Clinical Drug Evaluation Program were utilized. Response and location data extensive enough for analysis represented 6 sites of primary origin and 6 metastatic site groups, totalling 1687 lesions. Analysis of percentage reduction in tumour size after chemotherapy regimens of up to 60 days revealed a significant amount of variation associated with metastatic sites and a non-significant amount associated with sites of primary origin. Advanced primary tumours showed marked variation in responsiveness and some showed a difference in response to different drug groups. Generally, metastases responded better than the advanced primaries from which they were derived, except for those from breast tumours.

Topics: Antineoplastic Agents; Breast Neoplasms; Chlorambucil; Female; Fluorouracil; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Lung Neoplasms; Melanoma; Mercaptopurine; Mitomycins; Neoplasm Metastasis; Neoplasms

Topics: Adult; Antineoplastic Agents; Choriocarcinoma; Colchicine; Dactinomycin; Daunorubicin; Female; Flavonoids; Humans; Lung Neoplasms; Melphalan; Mercaptopurine; Methotrexate; Middle Aged; Mitomycins; Neoplasm Metastasis; Olivomycins; Pneumonectomy; Pregnancy; Uterine Neoplasms; Vinblastine

Topics: Adult; Choriocarcinoma; Dactinomycin; Drug Therapy, Combination; Female; Humans; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Russia; Streptonigrin; Time Factors; Trophoblastic Neoplasms; Uterine Neoplasms

Topics: Adult; Aged; Anemia, Hemolytic, Autoimmune; Autopsy; Azathioprine; Brain; Breast Neoplasms; Female; Hodgkin Disease; Humans; Immunosuppression Therapy; Infection Control; Infections; Kidney Transplantation; Lung; Lupus Erythematosus, Systemic; Male; Mercaptopurine; Middle Aged; Myocardium; Neoplasm Metastasis; Prednisone; Toxoplasmosis; Transplantation, Homologous

Topics: Adult; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Drug Therapy, Combination; Female; Humans; Hydatidiform Mole; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Remission, Spontaneous; Trophoblastic Neoplasms

Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Astrocytoma; Blood-Brain Barrier; Brain Neoplasms; Child; Child, Preschool; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Glioblastoma; Glioma; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Monomethylhydrazine; Neoplasm Metastasis; Vinblastine

Topics: Arachnoid; Asparaginase; Brain Neoplasms; Cerebrospinal Fluid; Child; Cyclophosphamide; Daunorubicin; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunotherapy; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisolone; Prednisone; Remission, Spontaneous; Vincristine

Topics: Adolescent; Asparaginase; Child; Chlorambucil; Cobalt Radioisotopes; Cyclophosphamide; Female; Humans; Lung Neoplasms; Male; Mandible; Mandibular Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Pregnenolone; Radiography; Sarcoma, Ewing; Vinblastine

Topics: Adolescent; Adult; Antineoplastic Agents; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Female; Follow-Up Studies; Head and Neck Neoplasms; Hemangiosarcoma; Humans; Infant; Lung Neoplasms; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Metastasis; Pregnancy; Prostatic Neoplasms; Sarcoma; Teratoma; Testicular Neoplasms; Thoracic Neoplasms; Thyroid Neoplasms; Triaziquone; Uterine Neoplasms; Vinblastine

Topics: Animals; Benzyl Compounds; Brain; DDT; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Kinetics; Leukemia; Liver; Lung Neoplasms; Lymphocytes; Mathematics; Melphalan; Mercaptopurine; Mice; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Thiotepa; Time Factors

Topics: Animals; Azauridine; Cyclophosphamide; Female; Male; Mammary Neoplasms, Experimental; Mercaptopurine; Mice; Neoplasm Metastasis; Premedication; Time Factors

Topics: Autopsy; Brain Neoplasms; Child; Child, Preschool; Daunorubicin; Humans; Leukemia; Male; Mercaptopurine; Neoplasm Metastasis; Prednisone; Time Factors; Vincristine

Topics: Adult; Choriocarcinoma; Female; Humans; Hysterectomy; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Postoperative Complications; Pregnancy

Topics: Animals; Benzopyrenes; Cyclophosphamide; Male; Mercaptopurine; Mice; Mice, Inbred CBA; Neoplasm Metastasis; Rats; Rats, Inbred Strains; Sarcoma, Experimental; Uracil

Topics: Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Nervous System Diseases; Nitrosourea Compounds; Pyrimethamine; Remission, Spontaneous; Time Factors

Topics: Adult; Female; Humans; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Pregnancy Complications; Prognosis; Trophoblastic Neoplasms; Uterine Neoplasms

Topics: Adult; Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Hydrazines; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Vinblastine

Topics: Adult; Choriocarcinoma; Female; Humans; Hydatidiform Mole; Hysterectomy; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Postoperative Complications; Pregnancy; Remission, Spontaneous; Thoracic Neoplasms; Uterine Neoplasms

Topics: Adult; Amines; Breast Neoplasms; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Imidazoles; Mercaptopurine; Methotrexate; Middle Aged; Mitomycins; Neoplasm Metastasis; Prednisone; Triazines; Vincristine

Topics: Adult; Blood Transfusion; Brain; Brain Neoplasms; Cerebral Angiography; Cerebrovascular Disorders; Choriocarcinoma; Dactinomycin; Encephalitis; Female; Headache; Hemiplegia; Humans; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Metastasis; Neurologic Manifestations; Pregnancy; Seizures; Uterine Neoplasms

Topics: Adult; Aged; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma, Bronchogenic; Drug Synergism; Humans; Hydroxypropiophenone; Lung Neoplasms; Mercaptopurine; Middle Aged; Neoplasm Metastasis; Neurotransmitter Agents; Reserpine; Time Factors; Urethane

Topics: Animals; Breast Neoplasms; Carcinoma; Cell Transformation, Neoplastic; Cyclophosphamide; Disease Models, Animal; DNA Replication; Female; Humans; Leukemia; Lymph Nodes; Mercaptopurine; Mice; Neoplasm Metastasis; Sarcoma

Topics: Adolescent; Adult; Antineoplastic Agents; Choriocarcinoma; Dactinomycin; Female; Humans; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy

Topics: Amputation, Surgical; Animals; Antineoplastic Agents; Cyclophosphamide; Fluorouracil; Mercaptopurine; Methotrexate; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Procarbazine; Prognosis; Vinblastine

Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Antineoplastic Agents; Bone Neoplasms; Bone Resorption; Child, Preschool; Cyclophosphamide; Diagnosis, Differential; Diagnostic Errors; Femoral Neoplasms; Ganglioneuroma; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplastic Cells, Circulating; Norepinephrine; Radiography; Splenic Neoplasms; Vincristine

Topics: Breast Neoplasms; Cobalt Isotopes; Cyclophosphamide; Dactinomycin; DNA, Neoplasm; Female; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Prednisone; Radiotherapy Dosage; RNA, Messenger; Testicular Neoplasms

Topics: Abortion, Septic; Adult; Choriocarcinoma; Diagnosis, Differential; Diagnostic Techniques, Surgical; Female; Humans; Hysterectomy; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pelvic Neoplasms; Pregnancy; Pregnancy Complications; Pregnancy Tests; Pregnancy, Ectopic

Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cyclophosphamide; Fluorouracil; Male; Mercaptopurine; Methotrexate; Mice; Mitomycins; Neoplasm Metastasis; Vinblastine

Topics: Adult; Choriocarcinoma; Chorionic Gonadotropin; Female; Humans; Immunoassay; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Vaginal Neoplasms

Topics: Agglutination Tests; Antigens; Blood Group Antigens; Blood Platelets; Erythrocytes; Female; Gallbladder Neoplasms; Hemagglutination Tests; Humans; Liver Neoplasms; Mercaptopurine; Middle Aged; Neoplasm Metastasis; Prednisone

Topics: Angiography; Calcinosis; Choriocarcinoma; Female; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy

Topics: Abortion, Missed; Abortion, Threatened; Adult; Choriocarcinoma; Chorionic Gonadotropin; Diagnosis, Differential; Female; Humans; Hysterectomy; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Uterine Neoplasms; Vaginal Neoplasms

Topics: Acute Disease; Adult; Aged; Female; Humans; Leukemia; Male; Mercaptopurine; Methylation; Middle Aged; Neoplasm Metastasis; Ribose

Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Dactinomycin; Drug Synergism; Humans; Lung Neoplasms; Mercaptopurine; Methotrexate; Mitomycins; Neoplasm Metastasis; Radiotherapy Dosage; Triaziquone

Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Azirines; Bronchial Neoplasms; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Synergism; Fluorouracil; Humans; Hydrazines; Injections, Intravenous; Lung Neoplasms; Mechlorethamine; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pleural Neoplasms; Vinblastine

Topics: Antineoplastic Agents; Azirines; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Synergism; Fluorouracil; Humans; Hydrazines; Lung Neoplasms; Mercaptopurine; Mesothelioma; Methotrexate; Neoplasm Metastasis; Vinblastine

Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Drug Synergism; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrazines; Injections, Intramuscular; Injections, Intravenous; Lectins; Lung Neoplasms; Mechlorethamine; Mercaptopurine; Methotrexate; Mouth Neoplasms; Neoplasm Metastasis; Pharyngeal Neoplasms; Urogenital Neoplasms; Vinblastine

Topics: Antibodies; Autoantibodies; Blood Group Incompatibility; Humans; Hydrocortisone; Isoantibodies; Liver Neoplasms; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Metastasis; Thymus Neoplasms

Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Female; Humans; Infant; Leukemia; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Paraplegia; Prednisolone; Retroperitoneal Neoplasms; Sarcoma, Ewing; Spinal Cord Neoplasms; Vinblastine; Vincristine; Wilms Tumor

Topics: Adult; Choriocarcinoma; Chorionic Gonadotropin; Humans; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Teratoma; Testicular Neoplasms

Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Choriocarcinoma; Dactinomycin; Dysgerminoma; Humans; Male; Mercaptopurine; Methotrexate; Middle Aged; Neoplasm Metastasis; Teratoma; Testicular Neoplasms

Topics: Aminopterin; Antineoplastic Agents; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Leukemia; Male; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Prednisone; Radiography; Vincristine; Wilms Tumor

Topics: Antibiotics, Antineoplastic; Cell Division; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Humans; Karyotyping; Leukocytes; Mercaptopurine; Neoplasm Metastasis; Nitrogen Mustard Compounds

Topics: Animals; Immune Sera; Mercaptopurine; Neoplasm Metastasis; Rats; Sarcoma, Yoshida

Topics: Animals; Dactinomycin; Floxuridine; Leukemia; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Neoplasm Metastasis; Pyrimidines; Sarcoma, Experimental; Thiotepa

Topics: Adrenal Cortex Hormones; Antimetabolites; Antineoplastic Agents; Child; Hodgkin Disease; Humans; Infant; Leukemia; Lymphatic Metastasis; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Neuroblastoma; Nitrogen Mustard Compounds; Toxicology; Vincristine

Topics: Choriocarcinoma; Female; Humans; Hydatidiform Mole, Invasive; Lung Neoplasms; Mercaptopurine; Neoplasm Metastasis; Neoplasms; Pregnancy; Prognosis; Surgical Procedures, Operative; Uterine Neoplasms

Topics: Adenocarcinoma; Blood Cell Count; Carcinoma, Renal Cell; Epoetin Alfa; Erythropoietin; Geriatrics; Humans; Kidney Neoplasms; Lung Neoplasms; Mercaptopurine; Neoplasm Metastasis; Neoplasms; Neoplasms, Second Primary; Nephrectomy

Topics: Antineoplastic Agents; Brain Neoplasms; Castration; Choriocarcinoma; Female; Humans; Hydatidiform Mole, Invasive; Hysterectomy; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasms; Pregnancy; Trophoblastic Neoplasms; Uterine Neoplasms

Topics: Choriocarcinoma; Electrocardiography; Female; Humans; Hydatidiform Mole; Lung Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Pregnancy; Uterine Neoplasms