mercaptopurine and Mouth-Neoplasms

A multiple drug regimen was given to 36 patients with advanced carcinomas of the head and neck. In 19 of the 24 patients who were assessable the tumour regressed more than 50%; in one it regressed by 25%; and in four it did not respond at all. Multiple drug chemotherapy should be given much earlier in the course of these cancers, preferably as an adjuvant to surgery or radiotherapy.

Topics: Antineoplastic Agents; Bleomycin; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Ear Neoplasms; Fluorouracil; Head; Head and Neck Neoplasms; Humans; Hydroxyurea; Laryngeal Neoplasms; Maxillary Neoplasms; Mercaptopurine; Methotrexate; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Tongue Neoplasms; Tonsillar Neoplasms; Vincristine

Topics: Alkaline Phosphatase; Aminopterin; Azaguanine; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Line; Chromosomes; Clone Cells; Culture Techniques; Enzyme Induction; Humans; Mercaptopurine; Mouth Neoplasms; Sulfhydryl Compounds

Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Drug Synergism; Humans; Hydrazines; Injections, Intravenous; Mercaptopurine; Methotrexate; Mouth Neoplasms; Thiotepa; Vinblastine

Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Drug Synergism; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrazines; Injections, Intramuscular; Injections, Intravenous; Lectins; Lung Neoplasms; Mechlorethamine; Mercaptopurine; Methotrexate; Mouth Neoplasms; Neoplasm Metastasis; Pharyngeal Neoplasms; Urogenital Neoplasms; Vinblastine

Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Cyclophosphamide; Female; Humans; Hydrazines; Male; Maxillary Neoplasms; Mercaptopurine; Methotrexate; Mouth Neoplasms; Vinblastine