mercaptopurine and Mandibular-Neoplasms

A patient, a 46-year-old female, with a malignant thymoma spreading to the extrathoracic region is described. She underwent a thoracotomy and received radiation therapy, but the myasthenic symptoms did not disappear. A metastatic thymoma of the right mandibula was removed 9 months after thoracotomy. Further examination revealed metastatic thymomas of the bone and liver. After the operation the patient received combination chemotherapy (vincristine, cyclophosphamide, 6-mercaptopurine, prednisone) and remained asymptomatic for 31 months. She was found to have a metastatic thymoma in the occipital lobe of the brain 3.5 years after thoracotomy, and died from infection of the lung. Distant metastases and chemotherapy in malignant thymoma are reviewed.

Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Brain Neoplasms; Cyclophosphamide; Female; Humans; Liver Neoplasms; Mandibular Neoplasms; Mercaptopurine; Middle Aged; Neoplasm Metastasis; Prednisone; Thymoma; Thymus Neoplasms; Vincristine

Topics: Adolescent; Asparaginase; Child; Chlorambucil; Cobalt Radioisotopes; Cyclophosphamide; Female; Humans; Lung Neoplasms; Male; Mandible; Mandibular Neoplasms; Mercaptopurine; Methotrexate; Neoplasm Metastasis; Neoplasm Recurrence, Local; Pregnenolone; Radiography; Sarcoma, Ewing; Vinblastine