mercaptopurine and Lymphatic-Diseases

Topics: Antineoplastic Agents; Asparaginase; Daunorubicin; Humans; Leucovorin; Leukemia; Lymphatic Diseases; Mercaptopurine; Methotrexate; Prednisolone; Vincristine

The three treatment regimens evaluated in this study (vinblastine alone versus prednisone and vinblastine versus prednisone and 6-mercaptopurine) proved to be about equally efficacious in children with histiocytosis x. Inasmuch as many physicians regard this disorder as one with a high mortality rate, it is worth emphasizing that 59 of the 83 patients (71% are living).

Topics: Adolescent; Age Factors; Child; Child, Preschool; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Infant; Infant, Newborn; Lymphatic Diseases; Male; Mercaptopurine; Prednisone; Remission, Spontaneous; Vinblastine

To assess the incidence of hemophagocytic lymphohistiocytosis (HLH) in a well-defined population of children with inflammatory bowel disease (IBD) and evaluate the common clinical and laboratory characteristics of individuals with IBD who developed HLH.. We conducted a retrospective study of all children who developed HLH over an 8-year period. The incidence of HLH in patients with IBD was calculated using US census data and a statewide project examining the epidemiology of pediatric IBD.. Among children in Wisconsin, 20 cases of HLH occurred during the study period; 5 cases occurred in children with IBD. Common characteristics include: Crohn's disease (CD), thiopurine administration, fever lasting more than 5 days, lymphadenopathy, splenomegaly, anemia, lymphopenia, and elevated serum triglycerides and ferritin. Of the patients, 4 had primary Epstein-Barr virus infections. The incidence of HLH among all children in Wisconsin was 1.5 per 100 000 per year. The risk was more than 100-fold greater for children with CD (P < .00001).. Pediatric patients with CD are at increased risk for developing HLH; primary Epstein-Barr virus infection and thiopurine administration may be risk factors.

Topics: Adolescent; Anemia; Azathioprine; Crohn Disease; Epstein-Barr Virus Infections; Ferritins; Fever; Humans; Immunosuppressive Agents; Incidence; Lymphatic Diseases; Lymphohistiocytosis, Hemophagocytic; Lymphopenia; Mercaptopurine; Retrospective Studies; Splenomegaly; Triglycerides; Wisconsin

A 3 months old girl presented with significant enlargement of liver, spleen and lymphnodes, with moderate anemia, thrombopenia and leucocytosis. In the differential count there was a shift to the left and an increase of monocyte-like cells (35%). Differential diagnosis included leucemoid reaction, infectious mononucleosis, myelo-proliferative disorder with a missing C chromosome and chronic myeloid leucemia. Clinical symptoms, cytochemistry and caryotype of bone marrow cells suggested infantile chronic myeloic leucemia and normal ALP index and possibly normal HbF. Treatment with 6-mercaptopurine was followed by partial remission. The therapeutic consequences of exact differential diagnosis are discussed.

Topics: Anemia; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Humans; In Vitro Techniques; Infant; Infectious Mononucleosis; Leukemia, Myeloid; Leukocytosis; Liver Diseases; Lymphatic Diseases; Mercaptopurine; Myeloproliferative Disorders; Splenic Diseases; Thrombocytopenia

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Autopsy; Bone Marrow; Central Nervous System; Child, Preschool; Chloramphenicol; Humans; Infant; Kidney; Liver; Lymph Nodes; Lymphatic Diseases; Male; Meninges; Mercaptopurine; Methotrexate; Reticulocytes; Skin Manifestations; Spleen; Vincristine

Topics: Acute Disease; Adolescent; Adult; Blood Cells; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Female; Humans; Karyotyping; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphatic Diseases; Male; Mercaptopurine; Middle Aged

Topics: Antineoplastic Agents; Asparaginase; Cell Division; Chemistry; Culture Techniques; Cytarabine; Daunorubicin; Depression, Chemical; DNA; Drug Combinations; Drug Resistance; Germ-Free Life; Half-Life; History, 20th Century; Hodgkin Disease; Humans; Leukemia; Lymphatic Diseases; Mercaptopurine; Remission, Spontaneous; Stimulation, Chemical; Thioguanine

Topics: Adult; Female; Glucocorticoids; Humans; Leukemia; Lymphatic Diseases; Mercaptopurine

Topics: Adolescent; Cholestasis; Female; Humans; Lymphatic Diseases; Mercaptopurine

Topics: Adrenal Cortex Hormones; Chlorambucil; Cyclophosphamide; Dermatitis, Exfoliative; Genetic Diseases, X-Linked; Geriatrics; Hodgkin Disease; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphoid; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Mycosis Fungoides; Neoplasms; Pathology; Peptide Nucleic Acids; Physiology; Sarcoma; Severe Combined Immunodeficiency

Topics: Bone Marrow Examination; Child; Drug Therapy; Genetic Diseases, X-Linked; Leukemia; Leukemia, Hairy Cell; Lymphatic Diseases; Mercaptopurine; Severe Combined Immunodeficiency

Topics: Child; Genetic Diseases, X-Linked; Histiocytosis, Langerhans-Cell; Humans; Infant; Leukemia, Hairy Cell; Lymphatic Diseases; Mercaptopurine; Prednisone; Radiotherapy; Severe Combined Immunodeficiency; X-Ray Therapy