mercaptopurine and Leukemia--Erythroblastic--Acute

Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone

A 54-year-old man was admitted to Kitano Hospital because of nuchal pain in November, 1984. The bone marrow was hypercellular with 18% of myeloblasts and 45% of erythroblasts many of which were megaloblastoid and positive for PAS-staining. BH-AC . DMP therapy induced a complete remission which was maintained for more than 3 years until April, 1988, when gingival swelling occurred. A biopsy of the gingiva revealed a diffuse infiltration of myeloblasts together with a few erythroblasts. Local irradiation resulted in he disappearance of the swelling. However, the microscopic infiltration of the leukemic cells in the gingiva still remained in December, 1988 when there was no apparent gingival swelling and the patient was in a second hematological remission. Bone marrow relapse occurred in September, 1988 and twice thereafter. Complete remissions were again achieved for the first two relapses and the leukemic infiltration of the gingiva disappeared after another irradiation. The third relapse was refractory to an intensive chemotherapy and the gingival swelling also recurred in July, 1989. The patient died of pneumonia in October, 1989. The gingiva may be more common site of extramedullary relapse. Careful observation of this organ would be necessary throughout the course of leukemias.

Topics: Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Gingival Neoplasms; Humans; Leukemia, Erythroblastic, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone; Remission Induction

Topics: Antineoplastic Combined Chemotherapy Protocols; Chromosome Aberrations; Cytarabine; Daunorubicin; Humans; Karyotyping; Leukemia, Erythroblastic, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone

A regime of treatment of acute non-lymphoblastic leukemia in adult, employing DMCP protocol, especially two step method consisting of daunorubicin, cytosine arabinoside, 6-mercaptopurine and prednisolone is described. Out of 32 adult patients with ANLL treated with DCMP regime 26 (81.3%) achieved complete remission. The median durations of complete remission and survival were 53 weeks and 54 weeks, respectively. The longest duration of complete remission was more than 220 weeks, and 3 cases are still maintaining initial complete remission more than 3 years.

Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Cytarabine; Daunorubicin; Drug Therapy, Combination; Female; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone; Remission, Spontaneous

Topics: Anemia, Pernicious; Blood Cell Count; Bone Marrow Cells; Cytarabine; Cytoplasm; Follow-Up Studies; Hematologic Diseases; Humans; In Vitro Techniques; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Megakaryocytes; Mercaptopurine; Plasmacytoma; Polycythemia; Thioguanine; Thrombocytopenia

Topics: Acute Disease; Adolescent; Adult; Aged; Drug Therapy, Combination; Female; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone; Prednisone

Topics: Acute Disease; Cytarabine; Female; Humans; Infant; Leukemia, Erythroblastic, Acute; Mercaptopurine; Methotrexate; Prednisolone

Topics: Adolescent; Appendicitis; Child; Child, Preschool; Gastrointestinal Diseases; Humans; Hypersplenism; Infant; Intestinal Obstruction; Intussusception; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mercaptopurine; Pancreatitis; Postoperative Complications; Prednisone; Thrombocytopenia; Time Factors

Topics: Cytarabine; Drug Synergism; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine

Topics: Acute Disease; Adolescent; Adult; Blood Cells; Chromosome Aberrations; Chromosome Disorders; Chromosomes; Female; Humans; Karyotyping; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Lymphatic Diseases; Male; Mercaptopurine; Middle Aged

Topics: Cytarabine; Folic Acid; Humans; Leukemia, Erythroblastic, Acute; Mercaptopurine; Methotrexate; Prednisone; Pyridoxine; Remission, Spontaneous; Vitamin B 12

Topics: Adolescent; Adult; Aged; Agranulocytosis; Allopurinol; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Blood Transfusion; Cytarabine; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Methotrexate; Middle Aged; Muramidase; Nausea; Prednisolone; Thrombocytopenia; Vincristine

Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents; Asparaginase; Cyclophosphamide; Cytosine Nucleotides; Female; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisone; Vincristine

Topics: Bone Marrow Examination; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, 1-3; Chromosomes, Human, 13-15; Chromosomes, Human, 19-20; Erythrocytes, Abnormal; Humans; Karyotyping; Leukemia, Erythroblastic, Acute; Male; Mercaptopurine; Mitosis; Prednisone; Vincristine

Topics: Aneuploidy; Chromosome Aberrations; Cytarabine; Humans; Karyotyping; Leukemia, Erythroblastic, Acute; Male; Mercaptopurine; Middle Aged; Polyploidy; Prednisone

Topics: Cytarabine; Humans; Leukemia, Erythroblastic, Acute; Mercaptopurine; Methotrexate; Prednisone

Topics: Adolescent; Adult; Age Factors; Aged; Bone Marrow; Bone Marrow Examination; Female; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukocyte Count; Longevity; Male; Mercaptopurine; Middle Aged; Prednisone; Prognosis; Sex Factors; Vincristine

Topics: Humans; Leukemia, Erythroblastic, Acute; Mercaptopurine; Steroids

Topics: Acid Phosphatase; Adolescent; Age Factors; Bone Marrow Examination; Child; Cyclophosphamide; Cytarabine; Diagnosis, Differential; Erythema; Erythrocytes; Humans; Leukemia, Erythroblastic, Acute; Male; Mercaptopurine; Myelography

Topics: Adolescent; Bone Marrow Examination; Child; Chromosome Aberrations; Chromosomes, Human, 6-12 and X; Culture Techniques; Cytarabine; Cytogenetics; Female; Humans; Karyotyping; Lectins; Leukemia, Erythroblastic, Acute; Male; Mercaptopurine; Mosaicism

Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Antineoplastic Agents; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Thrombocythemia, Essential; Vincristine

Topics: Adult; Anemia, Hemolytic; Diagnosis, Differential; Female; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone

Topics: Adrenal Cortex Hormones; Azaserine; Busulfan; Diagnosis, Differential; Drug Therapy; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Liver; Lymph Nodes; Mercaptopurine; Neoplasms; Pathology; Spleen