mercaptopurine and Kidney-Diseases

Topics: Abnormalities, Multiple; Abortion, Spontaneous; Collagen Diseases; Cyclophosphamide; Female; Gastrointestinal Diseases; Hematologic Diseases; Immune System Diseases; Immunosuppression Therapy; Immunosuppressive Agents; Kidney Diseases; Kidney Function Tests; Leukopenia; Liver Function Tests; Lymphoma; Mercaptopurine; Methotrexate; Nervous System Diseases; Pregnancy

Topics: Abnormalities, Drug-Induced; Alkylating Agents; Allopurinol; Alopecia; Antimetabolites; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cyclophosphamide; Drug Synergism; Female; Fetus; Humans; Kidney Calculi; Kidney Diseases; Kidney Tubules; Mechlorethamine; Mercaptopurine; Neoplasms; Pregnancy; Pregnancy Complications; Uric Acid; Vincristine

Topics: Adult; Azathioprine; Child; Child, Preschool; Cyclophosphamide; Glucocorticoids; Humans; Hydrocortisone; Intestinal Perforation; Intussusception; Kidney Diseases; Laparotomy; Mercaptopurine; Prednisone; Purpura

Topics: Anemia; Anemia, Aplastic; Animals; Blood Transfusion; Bone Marrow; Bone Marrow Cells; Cell Differentiation; Chronic Disease; Erythropoiesis; Erythropoietin; Humans; Immune Sera; Kidney; Kidney Diseases; Lipids; Mercaptopurine; Polycythemia Vera

This study examined renal function in 42 children with acute lymphoblastic leukemia (ALL) treated according to BFM-95 protocol. Fifteen (group 1) were investigated longitudinally at 3 time points: before (T1), 4 weeks after (T2), and 2-6 months after (T3) consolidation therapy with high-dose methotrexate (HDMTX). The frequency of abnormalities in glomerular and tubular tests were nil at T1 and ranged from 13 to 40% at T2 and 7 to 33% at T3 in group 1. Twenty percent of the patients (n = 10) in group 2, who were examined at a single time point 7-36 months after consolidation, had glomerular and tubular abnormalities. There was only mild tubular abnormality in 5.8% of patients (n = 17) in group 3, who were examined at a single time point a mean of 56.1 +/- 12.5 months after completion chemotherapy. These data show that consolidation therapy with HDMTX is frequently associated with acute renal toxicity in children with ALL but does not leave clinically significant late sequelae.

Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Female; Humans; Kidney Diseases; Kidney Function Tests; Longitudinal Studies; Male; Mercaptopurine; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Turkey; Vincristine

MRL/Mp-lpr/lpr (MRL/l) mice spontaneously develop autoimmune kidney disease which resembles human systemic lupus erythematosus (SLE). Employing this strain of mouse, we examined the effect of several immunosuppressants and a newly synthetized anti-nephritic agent, 4-chloro-3',6'-dimethyl-2,2'-iminodibenzoic acid (TO-115) on both the development of immunological abnormalities and the clinical symptoms of autoimmune kidney disease. This study aimed to determine how much the magnitude of autoantibody suppression related to the degree of prevention of autoimmune nephritis. Immunological abnormalities were assessed by measuring the serum levels of anti-deoxyribonucleic acid and anti-trinitrophenyl antibodies, rheumatoid factor (RF), and immune complex (IC). The status of autoimmune kidney disease was monitored by means of the appearance of proteinuria and survival time and the measurement of serum levels of blood urea nitrogen (BUN) and cholesterol. Immunosuppressants such as cyclophosphamide (CY), 6-mercaptopurine (6 MP) and sodium aurothiomalate (SAT) remarkably suppressed the development of immunological abnormalities in a dose dependent manner. Interestingly, however, only CY showed the suppressive effect on the development of autoimmune kidney disease with prolongation of survival time and the excretion of proteinuria. In contrast, 6-MP and SAT did not inhibit the development of autoimmune kidney disease. On the other hand, TO-115 did not suppress the development of immunological abnormalities, but it restrained the symptoms of autoimmune kidney disease. Taken together, the suppression of autoantibody production does not always lead to prevention of the development of autoimmune kidney disease.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Autoantibodies; Autoimmune Diseases; Blood Urea Nitrogen; Cholesterol; Cyclophosphamide; Gold Sodium Thiomalate; Immune Complex Diseases; Kidney Diseases; Mercaptopurine; Mice; ortho-Aminobenzoates

Similarity of the morphological picture of gouty nephropathy and primary glomerulonephritides in which purine antagonists turned out to be effective, a positive effect of azathioprine (Az) and 6-mercaptopurine (MP) on purine metabolism, and changes in immunity indices revealed in gout (hyperproduction of immunoglobulins and circulating immune complexes) necessitates the use of antimetabolites in combined therapy of gout patients with proteinuric and latent types of nephropathy. A prolonged use of Az and MP at a daily dose of 50-100 mg often leads to the recovery or improvement of lowered renal function, disappearance of the urinary syndrome, and suppression of hyperuricemia. Uricosuppressors without purine antagonists produce a weaker effect on the course of a renal process, and the treatment of such patients without the use of basic drugs has proved to be utterly ineffective. Strict control over Az and MP therapy makes side-effects of the drugs rare, and they can be easily done away with after reducing a drug dose.

Topics: Adult; Azathioprine; Drug Therapy, Combination; Gout; Humans; Kidney Diseases; Mercaptopurine; Middle Aged; Time Factors; Uric Acid

Topics: Ambulatory Care; Azathioprine; Cyclophosphamide; Glomerulonephritis; Humans; Indomethacin; Kidney Diseases; Kidney Failure, Chronic; Mercaptopurine; Renal Dialysis

Topics: Adolescent; Antimetabolites; Azathioprine; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Kidney Diseases; Lupus Erythematosus, Systemic; Male; Mercaptopurine

Topics: Adolescent; Adult; Aged; Antimalarials; Autoimmune Diseases; Azathioprine; Chlorambucil; Cyclophosphamide; Follow-Up Studies; Humans; Immunosuppressive Agents; Kidney Diseases; Lupus Erythematosus, Systemic; Mercaptopurine; Middle Aged; Prednisolone; Sex Factors

Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Animals; Autoimmune Diseases; Azathioprine; Corneal Transplantation; Dactinomycin; Humans; Immunosuppressive Agents; Kidney Diseases; Mercaptopurine; Plasmacytoma; Psoriasis; Transplantation Immunology

Topics: Acute Disease; Child, Preschool; Humans; Hypertrophy; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone

Topics: Adolescent; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Child; Child, Preschool; Chronic Disease; Female; Glomerulonephritis; Humans; Kidney Diseases; Kidney Function Tests; Liver Function Tests; Male; Mercaptopurine; Nephrotic Syndrome; Pyelonephritis

Topics: Adrenal Cortex Hormones; Amyloidosis; Anti-Inflammatory Agents; Azathioprine; Busulfan; Ethnicity; Familial Mediterranean Fever; Female; Humans; Kidney Diseases; Male; Mercaptopurine; Norsteroids; Steroids

Topics: Antineoplastic Agents; Azathioprine; Chlorambucil; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Diseases; Kidney Glomerulus; Mercaptopurine; Nephrotic Syndrome; Prednisone

Topics: Azathioprine; Chlorambucil; Collagen Diseases; Diabetic Nephropathies; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Diseases; Lupus Erythematosus, Systemic; Mercaptopurine; Nephrotic Syndrome

Topics: Azathioprine; Glomerulonephritis; Humans; Immunosuppressive Agents; Kidney Diseases; Mechlorethamine; Mercaptopurine

Topics: Adolescent; Child; Child, Preschool; Female; Humans; Kidney Diseases; Male; Mercaptopurine; Nephrosis, Lipoid; Prednisone

Topics: Adolescent; Bone Marrow Examination; Child; Child, Preschool; Erythrocyte Count; Erythropoiesis; Female; Glomerulonephritis; Hematopoietic System; Humans; Kidney Diseases; Male; Mercaptopurine; Nephrotic Syndrome; Prednisone; Pyelonephritis

Topics: Acetazolamide; Adolescent; Amphotericin B; Candidiasis; Humans; Infectious Mononucleosis; Kidney Diseases; Leukemia; Male; Mercaptopurine; Methotrexate; Nystatin; Penicillins; Peripheral Nervous System Diseases; Prednisone; Rolitetracycline; Sepsis; Uric Acid

Topics: Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Mercaptopurine; Transplantation, Homologous

Topics: Acute Kidney Injury; Adolescent; Blood; Dialysis; Humans; Kidney Diseases; Leukemia; Mercaptopurine; Metabolism; Methotrexate; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency; Toxicology; Uric Acid; Urine

Topics: Albuminuria; Drug Therapy; Humans; Kidney Diseases; Leukopenia; Lupus Erythematosus, Systemic; Lupus Nephritis; Mercaptopurine; Toxicology

Topics: Antigen-Antibody Reactions; Autoimmune Diseases; Cortisone; Hypertension; Hypertension, Renal; Infarction; Kidney; Kidney Diseases; Mercaptopurine; Pathology; Pharmacology; Precipitin Tests; Rats; Research