mercaptopurine and Infectious-Mononucleosis

Topics: Alkylating Agents; Animals; Antigen-Antibody Complex; Blood Viscosity; Collagen Diseases; Complement System Proteins; Cryoglobulins; Cytomegalovirus; DNA; Humans; Immune Complex Diseases; Immunoglobulin A; Immunoglobulin G; Immunosuppressive Agents; Infectious Mononucleosis; Mercaptoethanol; Mercaptopurine; Methotrexate; Penicillamine; Purpura; Rabbits; Raynaud Disease; Rheumatoid Factor; Vaccines

A 3 months old girl presented with significant enlargement of liver, spleen and lymphnodes, with moderate anemia, thrombopenia and leucocytosis. In the differential count there was a shift to the left and an increase of monocyte-like cells (35%). Differential diagnosis included leucemoid reaction, infectious mononucleosis, myelo-proliferative disorder with a missing C chromosome and chronic myeloid leucemia. Clinical symptoms, cytochemistry and caryotype of bone marrow cells suggested infantile chronic myeloic leucemia and normal ALP index and possibly normal HbF. Treatment with 6-mercaptopurine was followed by partial remission. The therapeutic consequences of exact differential diagnosis are discussed.

Topics: Anemia; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Humans; In Vitro Techniques; Infant; Infectious Mononucleosis; Leukemia, Myeloid; Leukocytosis; Liver Diseases; Lymphatic Diseases; Mercaptopurine; Myeloproliferative Disorders; Splenic Diseases; Thrombocytopenia

Topics: Adolescent; Ampicillin; Antibodies, Heterophile; Bone Marrow Examination; Cloxacillin; Female; Humans; Infectious Mononucleosis; Leukemia, Myeloid, Acute; Liver Function Tests; Mercaptopurine; Methotrexate; Prednisone; Vincristine

Topics: Adolescent; Adrenal Cortex Hormones; Adult; Animals; Antibodies, Viral; Asparaginase; Cyclophosphamide; Cytarabine; Fluorescent Antibody Technique; Guinea Pigs; Herpesvirus 4, Human; Humans; Hydrocortisone; Infectious Mononucleosis; Leukemia, Lymphoid; Male; Mercaptopurine; Methotrexate; Prednisone; Sheep; Vincristine

Topics: Basophils; Blood Cell Count; Blood Platelets; Child; Eosinophils; Hemoglobinometry; Humans; Infectious Mononucleosis; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Male; Mercaptopurine; Monocytes; Neutrophils; Prednisone

Topics: Acetazolamide; Adolescent; Amphotericin B; Candidiasis; Humans; Infectious Mononucleosis; Kidney Diseases; Leukemia; Male; Mercaptopurine; Methotrexate; Nystatin; Penicillins; Peripheral Nervous System Diseases; Prednisone; Rolitetracycline; Sepsis; Uric Acid

Topics: Adolescent; Antibody Formation; Arthritis; Arthritis, Juvenile; Blood Protein Disorders; Child; Cortisone; Hepatitis; Humans; Infectious Mononucleosis; Jaundice; Liver Function Tests; Mercaptopurine; Pathology; Plasma Cells; Splenomegaly; Toxicology