mercaptopurine and Herpes-Simplex

Topics: Acyclovir; Allopurinol; Animals; Drug Therapy; Folic Acid Antagonists; Herpes Simplex; Herpes Zoster; Humans; Leishmania; Mercaptopurine; Neoplasms; Nucleic Acid Synthesis Inhibitors; Recurrence; Species Specificity

Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bacterial Infections; Child, Preschool; Cyclophosphamide; Cytarabine; Daunorubicin; Encephalitis, Herpes Simplex; Fatal Outcome; Female; Hematopoietic Stem Cell Transplantation; Herpes Simplex; Humans; Induction Chemotherapy; Infant; Male; Mercaptopurine; Methotrexate; Opportunistic Infections; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Simplexvirus; Stomatitis, Herpetic; Vincristine; Virus Activation

5-Aminosalicylic acid (5-ASA)-containing drugs are the mainstay of therapy in inflammatory bowel disease, but adverse reactions to these medications are relatively common. Because there may be a lack of cross-reactivity among the various 5-ASA formulations, treatment with alternative preparations is sometimes possible even after an apparent allergic reaction to a 5-ASA product.. To describe a patient with a possible allergy to 2 different 5-ASA drugs who tolerated a third.. A 27-year-old man with Crohn disease developed a rash while taking mesalamine (Pentasa and Asacol). Treatment with 5-ASA products was discontinued, and 6-mercaptopurine and prednisone were prescribed. He then experienced multiorgan failure secondary to herpes simplex infection, which required discontinuation of the immunosuppressive therapy. After recovery from the acute infection, he underwent successful graded challenge with balsalazide.. The patient continued treatment with balsalazide for 9 months, with good control of his inflammatory bowel disease and no adverse effects.. Adverse reactions to 1 or more 5-ASA medications do not necessarily preclude the use of others in the same class. A treatment algorithm for patients with adverse reactions to 5-ASA is outlined based on the case report and review of the literature.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Crohn Disease; Cross Reactions; Drug Hypersensitivity; Exanthema; Herpes Simplex; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Mesalamine; Phenylhydrazines; Prednisone

The mutagenic activity of native and inactivated herpes simplex virus (HSV-1) has been studied. The native HSV-1 strain has been shown to induce the gene mutations of 6-mercaptopurine resistance in Chinese hamster cells. The 1.5- to 2-fold decrease of mutagenic activity is due to HSV inactivation by thiophosphamide and formalin treatment. These data indicate the possibility of the given agents application for decreasing of the genetic danger of antiviral vaccine.

Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance, Microbial; Formaldehyde; Herpes Simplex; Mercaptopurine; Mutation; Simplexvirus; Thiotepa; Virus Activation; Virus Cultivation

Topics: Animals; Body Weight; Brain; Coxsackievirus Infections; Female; Herpes Simplex; Interferons; Leukocytes; Leukopenia; Liver; Male; Mercaptopurine; Mice; Vaccinia

Topics: Aged; Female; Herpes Simplex; Humans; Leukemia, Myeloid, Acute; Mercaptopurine; Prednisone