mercaptopurine and Hand-Dermatoses

mercaptopurine has been researched along with Hand-Dermatoses* in 2 studies

Other Studies

2 other study(ies) available for mercaptopurine and Hand-Dermatoses

ArticleYear
Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema.
    Acta dermato-venereologica, 2018, Mar-13, Volume: 98, Issue:3

    Topics: Adult; Allopurinol; Azathioprine; Chronic Disease; Dermatitis, Atopic; Drug Therapy, Combination; Eczema; Female; Foot Dermatoses; Guanine Nucleotides; Hand Dermatoses; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thionucleotides; Time Factors; Treatment Outcome

2018
Toxic erythema of palms and soles associated with high-dose mercaptopurine chemotherapy.
    Archives of dermatology, 1986, Volume: 122, Issue:12

    We encountered a case of distinctive palmar-plantar erythema with desquamation of the fingers in a patient receiving high-dose mercaptopurine combined with allopurinol. He was receiving 400 mg/d of mercaptopurine with 200 mg/d of allopurinol when a painful, livid erythema involving his hands and feet developed. Over the ensuing 24 hours, desquamation of the distal fingertips was noted. The mercaptopurine was discontinued and the patient was treated with topical fluocinonide ointment under occlusion. Over the next 96 hours, the erythema and pain resolved entirely. To date, this is the eighth case of a painful desquamating erythema of the palms and soles occurring as a complication of chemotherapy. We suggest that high-dose mercaptopurine combined with allopurinol that blocks xanthine oxidase, a necessary enzyme in the catabolism of mercaptopurine, was responsible for our patient's clinical presentation.

    Topics: Adult; Drug Eruptions; Erythema; Foot Dermatoses; Hand Dermatoses; Humans; Male; Mercaptopurine

1986