mercaptopurine and Glomerulonephritis--Membranoproliferative

mercaptopurine has been researched along with Glomerulonephritis--Membranoproliferative* in 1 studies

Other Studies

1 other study(ies) available for mercaptopurine and Glomerulonephritis--Membranoproliferative

ArticleYear
[Homozygote deficiency of thiopurine methyltransferase. A contraindication to the use of azathioprine in kidney transplantation].
    Presse medicale (Paris, France : 1983), 1995, Sep-23, Volume: 24, Issue:27

    Azathioprine-induced myelosuppression is the most important side effect observed in kidney transplantation. We report a case of severe neutropenia after kidney transplantation due to a thiopurine methyltransferase deficiency. This cause of azathioprine-induced myelotoxicity is rare, but its infectious consequences may be severe. Thiopurine methyltransferase deficiency must therefore be suspected when early and severe leukopenia occurs during azathioprine therapy. Erythrocyte thiopurine methyltransferase activity measurement confirms the diagnosis. Azathioprine and 6-mercaptopurine must afterwards be definitively avoided.

    Topics: Azathioprine; Contraindications; Female; Glomerulonephritis, Membranoproliferative; Graft Rejection; Homozygote; Humans; Kidney Failure, Chronic; Kidney Transplantation; Leukopenia; Mercaptopurine; Methyltransferases; Middle Aged; Postoperative Complications; Transplantation, Homologous

1995