mercaptopurine and Gangrene

We describe a patient who developed pyoderma gangrenosum during the remission phase of acute myeloid leukaemia whilst receiving maintenance therapy with methotrexate and 6-mercaptopurine. The spontaneous resolution of these skin lesions following discontinuation of chemotherapy suggests that these drugs may be of major significance in the aetiology of pyoderma gangrenosum. Nevertheless, 27 months later, a relapse of the leukaemia followed. Although pyoderma gangrenosum occurred during clinical remission, we cannot rule out a synergism of leukaemia and chemotherapy in its pathogenesis.

Topics: Adult; Gangrene; Humans; Immunosuppression Therapy; Leukemia, Myeloid; Male; Mercaptopurine; Methotrexate; Pyoderma

Topics: Acute Disease; Adolescent; Female; Gangrene; Humans; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Prednisolone; Pyoderma; Rifampin

Topics: Adult; Crohn Disease; Female; Gangrene; Humans; Intestinal Obstruction; Mercaptopurine; Prednisone; Pyoderma

Topics: Adrenocorticotropic Hormone; Gangrene; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Mercaptopurine; Penicillins; Prednisolone; Skin