mercaptopurine and Choroiditis

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antibiotics, Antineoplastic; Antilymphocyte Serum; Azathioprine; Behcet Syndrome; Chlorambucil; Choroiditis; Corneal Transplantation; Deafness; Eye Diseases; Graves Disease; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Meningoencephalitis; Mercaptopurine; Multiple Sclerosis; Ophthalmia, Sympathetic; Postoperative Care; Retinal Detachment; Retinal Hemorrhage; Uveitis

To report the clinical profile and management of patients diagnosed to have ampiginous choroiditis in a tertiary care referral centre in India.. Retrospective cohort study. Twenty-six eyes of 16 patients were included in the study, which was diagnosed as choroiditis, serpiginous choroiditis, and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) or ampiginous choroiditis. Those who were initially diagnosed as having other forms of choroiditis were later classified as having ampiginous choroiditis clinically. Systemic steroids and immunosuppressives were the mainstay of therapy.. There was a male preponderance (7:3). Age at presentation ranged from 22 years to 57 years with a (median 34 years); 81% had bilateral involvement and 35% had recurrences. Vision improved or maintained in 24 eyes, whereas it deteriorated in 2 eyes due to subretinal fibrosis and macula involvement, respectively. Resolution of lesions and improvement or stability of vision can occur with administration of timely steroids and immunosuppressive therapy. Regular follow-up is necessary to monitor the disease progression, recurrences, and involvement of the other eye.. Ampiginous choroiditis is a separate disease entity due to its distinct clinical features. It is a disease with multiple relapses, which can be effectively controlled with a combination of immunosuppressive therapy, and a good visual acuity can be maintained on long-term follow-up.

Topics: Adult; Chorioretinitis; Choroiditis; Cohort Studies; Cyclosporine; Female; Humans; Immunosuppressive Agents; India; Male; Mercaptopurine; Middle Aged; Prednisolone; Retrospective Studies; Treatment Outcome; Visual Acuity