mercaptopurine and Carcinoma

Childhood adrenocortical carcinoma (ACC) is a rare tumor and its association with acute lymphoblastic leukemia (ALL) is even rarer. One such case is discussed in this case report. A 3-year-old patient was concomitantly diagnosed with ALL and an initially nonmetastatic ACC. Management started by following the Total XV protocol without a window phase. Left adrenalectomy was conducted after the consolidation phase. Recurrence of a mass at the tumor bed was discovered at week 33 of the continuation phase. Reexcision was conducted, followed by the administration of an ACC protocol including cisplatin, etoposide, and doxirubicin. Mitotane was added when a pulmonary metastasis was discovered and then stopped after the patient suffered from an arachnoid cyst and speech difficulties. The ALL protocol was resumed from week 34 of the continuation phase. Progression of pulmonary nodules was noted after week 45. A pulmonary metastectomy was performed. The ALL protocol was resumed up to week 51 with a good response as proven by assessment of minimal residual disease. A further recurrence was diagnosed at the abdominal tumor bed with a paravertebral mass and a pulmonary nodule. The patient was assigned to palliative treatment and died after a 32-month survival. Such rare associations need more extensive discussions of the best possible management in scientific literature.

Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Combined Modality Therapy; Doxorubicin; Etoposide; Fatal Outcome; Humans; Language Development Disorders; Lung Neoplasms; Mercaptopurine; Methotrexate; Mitoxantrone; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Nephrectomy; Pneumonectomy; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Topics: Adult; Azathioprine; Carcinoma; Colonic Neoplasms; Crohn Disease; Humans; Mercaptopurine

Lambdamycin, a chromoglycoside antibiotic like chartreusin was found to be very active against leukemias L 1210 and P 388 and moderate effective against melanoma B 16 and Lewis lung carcinoma of mice. It was nearly without any effect when tested on Walker 256 carcinoma of rats. The effectiveness of lambdamycin was compared with that of cyclophosphamide, 5-fluorouracil and 6-mercaptopurine.

Topics: Animals; Benzopyrans; Carcinoma; Cyclophosphamide; Fluorouracil; Glycosides; Leukemia, Experimental; Melanoma; Mercaptopurine; Mice; Rats

Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinoma; Diet; Diet, Sodium-Restricted; Duodenal Neoplasms; Mercaptopurine; Mitosis; Neoplasms, Experimental; Rats

Topics: Antimetabolites; Azaguanine; Carcinoma; Cell Division; Cell Line; Cell Survival; Cytarabine; DNA Replication; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Hydroxyurea; Laryngeal Neoplasms; Mercaptopurine; Methotrexate; Mitosis; Ribonucleosides; Thioguanine; Time Factors; Tritium

Topics: Animals; Ascites; Body Weight; Carcinoma; Carcinoma 256, Walker; Coenzymes; Female; Half-Life; Liver; Lung; Male; Mercaptopurine; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Sarcoma; Spleen; Time Factors; Transplantation, Homologous

Topics: Animals; Breast Neoplasms; Carcinoma; Cell Transformation, Neoplastic; Cyclophosphamide; Disease Models, Animal; DNA Replication; Female; Humans; Leukemia; Lymph Nodes; Mercaptopurine; Mice; Neoplasm Metastasis; Sarcoma

Topics: Animals; Biological Assay; Carcinoma; Cyclophosphamide; Female; Mammary Neoplasms, Experimental; Mercaptopurine; Mice; Neoplasm Transplantation

Topics: Androgens; Antibiotics, Antineoplastic; Antineoplastic Agents; Ascorbic Acid; Azirines; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Synergism; Fluorouracil; Glucocorticoids; Humans; Hydrazines; Injections, Intramuscular; Injections, Intravenous; Lectins; Lung Neoplasms; Mechlorethamine; Mercaptopurine; Mesothelioma; Methotrexate; Phenylbutazone; Pleural Neoplasms; Thiotepa; Vinblastine

Topics: Antineoplastic Agents; Azirines; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Colchicine; Cyclophosphamide; Drug Synergism; Fluorouracil; Humans; Hydrazines; Injections, Intravenous; Mechlorethamine; Mercaptopurine; Methotrexate; Thiotepa; Vinblastine

Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Dactinomycin; Drug Synergism; Humans; Lung Neoplasms; Mercaptopurine; Methotrexate; Mitomycins; Neoplasm Metastasis; Radiotherapy Dosage; Triaziquone

Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Drug Synergism; Female; Fluorouracil; Humans; Hydrazines; Injections, Intramuscular; Injections, Intravenous; Lung Neoplasms; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Middle Aged; Vinblastine

Topics: Antineoplastic Agents; Azirines; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Synergism; Fluorouracil; Humans; Hydrazines; Lung Neoplasms; Mercaptopurine; Mesothelioma; Methotrexate; Neoplasm Metastasis; Vinblastine

Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Drug Synergism; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrazines; Injections, Intramuscular; Injections, Intravenous; Lectins; Lung Neoplasms; Mechlorethamine; Mercaptopurine; Methotrexate; Mouth Neoplasms; Neoplasm Metastasis; Pharyngeal Neoplasms; Urogenital Neoplasms; Vinblastine

Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Azirines; Betamethasone; Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Lectins; Lung Neoplasms; Male; Mechlorethamine; Mercaptopurine; Methotrexate; Middle Aged; Pleural Neoplasms; Sarcoma; Vinblastine

Topics: Adenocarcinoma; Adult; Aged; Anti-Bacterial Agents; Breast Neoplasms; Carcinoma; Female; Fluorouracil; Humans; Leukemia, Myeloid; Lymphatic Metastasis; Mastectomy; Mercaptopurine; Methotrexate; Middle Aged

Topics: Aged; Carcinoma; Chromosome Aberrations; Chromosome Disorders; Diploidy; Humans; Karyotyping; Laryngeal Neoplasms; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Mitosis; Prednisone

Topics: Animals; Antimetabolites; Caffeine; Carcinoma; Carcinoma, Ehrlich Tumor; Liver; Mercaptopurine; Metabolism; Mice; Purines; Pyrimidines; Research; Sulfhydryl Compounds; Theobromine; Theophylline

Topics: Biopsy; Bone Marrow Cells; Carcinoma; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Lymphoma; Mercaptopurine; Multiple Myeloma; Myositis; Neoplasms; Polymyositis; Prednisone; Sarcoma

Topics: Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Lactates; Mercaptopurine; Metabolism; Nucleosides; Research; Thioinosine

Topics: Animals; Carcinoma; Carcinoma, Ehrlich Tumor; Chromatography; DNA; DNA, Neoplasm; Glycine; Injections, Intraperitoneal; Mercaptopurine; Metabolism; Mice; Nucleosides; Nucleotides; Pharmacology; Research; RNA; RNA, Neoplasm; Toxicology; Urine

Topics: Adenine Nucleotides; Animals; Ascites; Azaserine; Carcinoma; Carcinoma, Ehrlich Tumor; Chromatography; Histocytochemistry; Mercaptopurine; Metabolism; Mice; Neoplasms, Experimental; Nucleotides; Pharmacology; Phosphoric Monoester Hydrolases; Research

Topics: 5'-Nucleotidase; Animals; Ascites; Carcinoma; Carcinoma, Ehrlich Tumor; Mercaptopurine; Nucleotidases

Topics: Acridines; Adenine; Animals; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Guanine; Liver; Mercaptopurine; Mice; Neoplasms; Nucleotides; Pharmacology; Proteins; Research

Topics: Animals; Biosynthetic Pathways; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Formates; Glycine; Leukemia L1210; Mercaptopurine; Metabolism; Nucleotides; Purines; Research; RNA; RNA, Neoplasm; Sarcoma 180

Topics: Animals; Antineoplastic Agents; Arsenicals; Carbamates; Carcinoma; Carcinoma, Ehrlich Tumor; Colchicine; Dactinomycin; Diethylstilbestrol; Enzyme Inhibitors; Fluorouracil; Hydrocortisone; In Vitro Techniques; Mechlorethamine; Mercaptopurine; Methotrexate; Mice; Oxidoreductases; Research; Thalidomide; Thiotepa

Topics: Animals; Antimetabolites; Biochemical Phenomena; Carcinoma; Carcinoma, Ehrlich Tumor; Glucosyltransferases; Mercaptopurine; Metabolism; Nucleosides; Nucleotidases; Nucleotides; Nucleotidyltransferases; Pharmacology; Research

Topics: Carcinoma; Carcinoma, Squamous Cell; Humans; Mercaptopurine; Purines

Topics: Ascites; Biochemical Phenomena; Carcinoma; Humans; Mercaptopurine; Neoplasms; Nucleosides; Nucleotides

Topics: Ascites; Biochemical Phenomena; Carcinoma; Mercaptopurine; Neoplasms; Nucleosides; Nucleotides

Topics: Carcinoma; Carcinoma, Squamous Cell; Humans; Mercaptopurine; Reproduction

Topics: Animals; Antineoplastic Agents; Carcinoma; Mercaptopurine; Mitomycin; Sarcoma, Experimental

Topics: Animals; Ascites; Carcinoma; Mercaptopurine; Neoplasms, Experimental

Topics: Antimetabolites; Ascites; Carcinoma; Mercaptopurine; Neoplasms; Nucleosides; Nucleotides; Purine Nucleosides

Topics: Antimetabolites; Ascites; Carcinoma; Humans; Mercaptopurine; Neoplasms; Physiological Phenomena

Topics: Adenine; Animals; Antimetabolites; Carcinoma; Carcinoma, Squamous Cell; Humans; Mercaptopurine; Neoplasms; Neoplasms, Experimental