mercaptopurine and Arthritis

Topics: Anatomy; Arthritis; Autoantibodies; Betamethasone; Dexamethasone; Dihydroxyphenylalanine; Epidemiology; Histoplasmosis; Hypersensitivity; Melanoma; Mercaptopurine; Oxyphenbutazone; p-Methoxy-N-methylphenethylamine; Phenothiazines; Physiology; Prednisolone; Prednisone; Sarcoidosis; Toxicology; Toxoplasmosis; Triamcinolone; Uvea; Uveitis; Virus Diseases

Topics: Arthritis; Humans; Mercaptopurine; Psoriasis

Topics: Animals; Anti-Bacterial Agents; Arthritis; Arthritis, Experimental; Female; Hindlimb; Immunosuppressive Agents; Mercaptopurine; Rats; Ribonucleosides; Structure-Activity Relationship

Daily oral administration of 6-mercaptopurine suppressed the development of the secondary (immune) lesions of adjuvant arthritis in a dose-related manner. The degrees of arthritis suppression corresponded closely to suppressions of concurrent development of the humoral and the cellular immune response to El4 cells. A short course of therapy during the sensitization period (day - 1 to day 5 when the day of adjuvant injection is designated as day 0) appeared to be almost as effective as continued daily dosing (day - 1 to day 15). The drug did not influence the development of the primary (nonimmune) lesions of adjuvant arthritis at all dosage levels investigated. Chronic pretreatment with 10 mg/kg/day PO for 17 days had no effect on the development of carrageenin-induced acute inflammation in the rat. The suppression of adjuvant arthritis by 6-mercaptopurine, unlike suppression by cyclophosphamide, appears to result primarily from its suppressive action on the immune response.

Topics: Animals; Antibody Formation; Arthritis; Arthritis, Experimental; Carrageenan; Cell Line; Cyclophosphamide; Dose-Response Relationship, Drug; Edema; Immunity, Cellular; Mercaptopurine; Mice; Mice, Inbred Strains; Phenylbutazone; Rats; Time Factors

Tilorone (5-35 mg/kg/day) suppressed the development of adjuvant-induced arthritis and the concurrent development of cell-mediated immune response to a secondary immunogen(EL4 cells) in a dose-related manner. Its influence on the development of the humoral immune response tp EL4 cells was found to be dependent on dosage: stimulatory at low doses (7.5 and 11.0 mg/kg/day), but inhibitory at high doses (24.0 and 35.0 mg/kg/day). Single doses of tilorone (30-300 mg/kg), administered at 24 hours or 1 hour before the injection of carrageenan, suppressed the development of acute inflammation in the rat. Evidence is presented that neither the anti-inflammatory effect of tilorone, nor its influence on the immune response could account for its antiarthritic effect. It appears plausible that the compound may act via interferon induction.

Topics: Animals; Arthritis; Arthritis, Experimental; Cell Line; Fluorenes; Immunity; Immunity, Cellular; Inflammation; Male; Mercaptopurine; Neoplasms, Experimental; Phenylbutazone; Rats; Rats, Inbred Strains; Tilorone

Topics: Adjuvants, Immunologic; Animals; Antibodies; Antibody Formation; Antigens, Bacterial; Arthritis; Bordetella pertussis; Diethylamines; Encephalomyelitis, Autoimmune, Experimental; Erythrocytes; Escherichia coli; Female; Fluorenes; Hemolytic Plaque Technique; Hypersensitivity, Delayed; Immunity, Cellular; Immunization; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Mercaptopurine; Mice; Passive Cutaneous Anaphylaxis; Sheep; Stimulation, Chemical; Tuberculin Test

Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Azathioprine; Carrageenan; Connective Tissue; Connective Tissue Cells; Cyclophosphamide; Edema; Female; Hydrocortisone; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Mycobacterium; Rats; Time Factors

Topics: Animals; Antineoplastic Agents; Arthritis; Chickens; Columbidae; Cyclophosphamide; Cytarabine; Dactinomycin; Hybridization, Genetic; Inflammation; Male; Mercaptopurine; Nitrosourea Compounds; Procarbazine; Uric Acid; Vinblastine; Vincristine

Topics: Animals; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Arthritis; Aspirin; Azathioprine; Chloramphenicol; Cyclophosphamide; Dexamethasone; Drug Antagonism; Edema; Hydrocortisone; Immunosuppressive Agents; Indomethacin; Inflammation; Male; Mefenamic Acid; Mercaptopurine; Nystatin; Phenylacetates; Phenylbutazone; Prednisolone; Rats; Rifampin; Triamcinolone

Topics: Arthritis; Collagen Diseases; Female; Humans; Male; Mercaptopurine; Methotrexate

Topics: Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Blood Cell Count; Body Weight; Cortisone; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Male; Mercaptopurine; Organ Size; Phenylbutazone; Rats

Topics: Adrenal Cortex Hormones; Antimetabolites; Arthritis; Azathioprine; Blood Sedimentation; Humans; Immunosuppressive Agents; Mercaptopurine; Methotrexate

Topics: Arthritis; Cyclophosphamide; Humans; Male; Mercaptopurine; Middle Aged; Nitrogen Mustard Compounds; Psoriasis

Topics: Arthritis; Freund's Adjuvant; Mercaptopurine; Pharmacology; Rats; Research; Toxicology

Topics: Adolescent; Antibody Formation; Arthritis; Arthritis, Juvenile; Blood Protein Disorders; Child; Cortisone; Hepatitis; Humans; Infectious Mononucleosis; Jaundice; Liver Function Tests; Mercaptopurine; Pathology; Plasma Cells; Splenomegaly; Toxicology

Topics: Adolescent; Arthritis; Arthritis, Juvenile; Attention; Diagnosis, Differential; Humans; Leukemia; Mercaptopurine; Prednisone

Topics: Aminocaproates; Aminocaproic Acid; Animals; Antibodies; Antibody Formation; Arthritis; Arthritis, Experimental; Complement Fixation Tests; Mercaptopurine; Mycobacterium; Rats; Research; Tuberculin

Topics: Adjuvants, Immunologic; Allergy and Immunology; Arthritis; Drug Hypersensitivity; Immunosuppressive Agents; Injections, Intramuscular; Injections, Intraperitoneal; Mechlorethamine; Mercaptopurine; Methotrexate; Pharmacology; Radiation Effects; Rats; Research; Tuberculin; Tuberculin Test

Topics: Arthritis; Arthritis, Rheumatoid; Humans; Mercaptopurine