mercaptopurine and Anemia--Hemolytic

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anemia; Anemia, Hemolytic; Antibody Formation; Antigens; Autoimmune Diseases; Autoimmunity; gamma-Globulins; Haptoglobins; Immune Tolerance; Mechlorethamine; Mercaptopurine; Quinidine; Research; Splenectomy; Thymus Gland; Toxicology; Transplantation Immunology

In a 37 year old renal transplant woman haemolytic anaemia was observed in the course of a combined azathioprine-allopurinol therapy. Azathioprine is converted to 6-mercaptopurine, which then catalyzed by xanthine oxidase is oxidized to 6-thiouric acid. When allopurinol and azathioprine are administered simultaneously, high 6-mercaptopurine concentrations in plasma may be expected because of inhibition of xanthine oxidase activity by allopurinol. We assume that elevated plasma 6-mercaptopurine concentration could possibly be responsible for haemolytic anaemia in this renal transplant patient.

Topics: Adult; Allopurinol; Anemia, Hemolytic; Azathioprine; Drug Therapy, Combination; Female; Humans; Kidney Transplantation; Mercaptopurine; Transplantation, Homologous

Topics: Alcoholism; Anemia, Hemolytic; Anemia, Hypochromic; Anticonvulsants; Azathioprine; Deoxyuridine; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Erythropoiesis; Evaluation Studies as Topic; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Mercaptopurine; Sulfamethoxazole; Thioguanine; Trimethoprim; Vitamin B 12 Deficiency

Topics: Anemia, Hemolytic; Antineoplastic Agents; Autoimmune Diseases; Azathioprine; Collagen Diseases; Humans; Lupus Erythematosus, Systemic; Mercaptopurine; Sjogren's Syndrome; Thrombocytopenia

Topics: Anemia; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Anemia, Sideroblastic; Azathioprine; Dactinomycin; Fluorouracil; Humans; Immunosuppressive Agents; Mercaptopurine

Topics: Anemia, Hemolytic; Antilymphocyte Serum; Azathioprine; Fludrocortisone; gamma-Globulins; Humans; Mercaptopurine; Methods

Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Agranulocytosis; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Azathioprine; Child; Child, Preschool; Female; Humans; Immunosuppressive Agents; Infant; Male; Mercaptopurine; Middle Aged; Prednisone; Purpura, Thrombocytopenic; Splenectomy; Thrombocytopenia

Topics: Anemia, Hemolytic; Culture Techniques; Cyclophosphamide; Cytarabine; Humans; Immune Tolerance; Lectins; Leukemia; Lymphocytes; Mercaptopurine; Methotrexate; Neoplasms; Prednisolone; Smallpox Vaccine; Uveitis; Vincristine

Topics: Adult; Anemia, Hemolytic; Diagnosis, Differential; Female; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Middle Aged; Prednisolone

Topics: Anemia; Anemia, Hemolytic; Betamethasone; Chlorambucil; Dexamethasone; Geriatrics; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Mechlorethamine; Mercaptopurine; Methylprednisolone; Pharmacology; Prednisone; Radiotherapy; Thrombocytopenia; Triamcinolone

Topics: Anemia; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Humans; Mercaptopurine

Topics: Adrenal Cortex Hormones; Anemia; Anemia, Hemolytic; Blood Transfusion; Diagnosis; Hemoglobinuria; Hemoglobinuria, Paroxysmal; Humans; Mercaptopurine

Topics: Adrenocorticotropic Hormone; Anemia; Anemia, Hemolytic; Blood Transfusion; Humans; Mercaptopurine; Prednisone

Topics: Adrenal Cortex Hormones; Agammaglobulinemia; Anemia; Anemia, Hemolytic; Autoimmune Diseases; Blood Protein Disorders; gamma-Globulins; Humans; Leukemia; Lymphoma; Mercaptopurine; Nitrogen Mustard Compounds; Waldenstrom Macroglobulinemia

Topics: Anemia; Anemia, Hemolytic; Dermatitis, Atopic; Dermatitis, Contact; Eczema; Humans; Lupus Erythematosus, Systemic; Mercaptopurine; Scleroderma, Systemic; Thioguanine

Topics: Anemia; Anemia, Hemolytic; Female; Hemorrhage; Humans; Hypersensitivity; Mercaptopurine; Postpartum Hemorrhage; Postpartum Period