mercaptopurine and Anaphylaxis

One hundred and ninety-one cases of acute lymphoblastic leukaemia were entered in a trial in which, for five months, all received cytotoxic therapy with prednisolone, vincristine, mercaptopurine, L-asparaginase, and methotrexate (the latter in high dosage followed by folinic acid). Patients were then randomized to receive immunotherapy (B.C.G.), twice-weekly methotrexate, or no further treatment.One hundred and seventy-seven patients (93%) achieved full remission and at the time of analysis, 26 months from the beginning of the trial, 143 were still alive, including 70 in their first remission. Median "post-intensive" remission lengths were 17 weeks (no treatment), 27 weeks (B.C.G.), and 52 weeks (methotrexate). The prolongation of remission by methotrexate was most evident in those patients with low initial white cell counts. B.C.G. seemed to cause lymphocytosis but was without other conspicuous effect. The incidence of toxic reactions is reported, including an unusually low rate of anaphylaxis with L-asparaginase.These preliminary results are discussed and compared with those of similar trials.

Topics: Acute Disease; Adolescent; Adult; Anaphylaxis; Asparaginase; BCG Vaccine; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Leucovorin; Leukemia, Lymphoid; Leukocyte Count; Lymphocytes; Lymphocytosis; Mercaptopurine; Methotrexate; Prednisolone; Remission, Spontaneous; Skin Tests; Tuberculin Test; Vincristine

Topics: Allopurinol; Anaphylaxis; Anemia; Antibiotics, Antineoplastic; Bicarbonates; Blood Transfusion; Child; Child, Preschool; Cystitis; Disseminated Intravascular Coagulation; Erythrocytes; Female; Furosemide; Heart Arrest; Heparin; Humans; Hydrogen-Ion Concentration; Kidney; Leukemia; Lung Diseases; Male; Mercaptopurine; Mutation; Neoplasms; Phospholipids; Renal Dialysis; Thrombocytopenia; Uric Acid

Topics: Adolescent; Anaphylaxis; Asparaginase; Child; Child, Preschool; Confusion; Daunorubicin; Female; Hallucinations; Hemorrhage; Humans; Injections, Spinal; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Mercaptopurine; Methotrexate; Pancreatitis; Prednisolone; Retroperitoneal Space; Vinblastine; Vincristine

Topics: Anaphylaxis; Animals; Antigens; Antineoplastic Agents; Binding Sites, Antibody; Blood Proteins; Dogs; Epitopes; Guinea Pigs; Humans; Immune Sera; Immunization, Passive; Mercaptopurine; Mice; Protein Binding; Rabbits; Sarcoma 180

Topics: Adult; Aged; Anaphylaxis; Asparaginase; Asparagine; Aspartic Acid; Daunorubicin; Drug Hypersensitivity; Erwinia; Escherichia coli; Female; Half-Life; Humans; Leukemia, Lymphoid; Male; Mercaptopurine; Prednisone; Vincristine

Topics: Adolescent; Adult; Aged; Allopurinol; Anaphylaxis; Asparaginase; Blood Coagulation Disorders; Cytarabine; Daunorubicin; Drug Hypersensitivity; Female; Fever; Gastrointestinal Hemorrhage; Hallucinations; Humans; Hyperglycemia; Injections, Intravenous; Jaundice; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Liver; Male; Mercaptopurine; Methotrexate; Middle Aged; Oral Hemorrhage; Prednisone; Thioguanine; Uremia; Vincristine; Vomiting

Topics: Aminopyrine; Analgesics; Anaphylaxis; Animals; Anti-Inflammatory Agents; Aspirin; Bradykinin; Capillary Permeability; Carrageenan; Croton Oil; Depression, Chemical; Edema; Exudates and Transudates; Female; Guinea Pigs; Indomethacin; Inflammation; Male; Mefenamic Acid; Mercaptopurine; Mice; Phenylbutazone; Phenytoin; Pregnanes; Protein Denaturation; Rabbits; Radiation-Protective Agents; Rats; Sulfones; Yeast, Dried

Topics: Anaphylaxis; Animals; Antibiotics, Antineoplastic; Cortisone; Depression, Chemical; Disease Models, Animal; Flavonoids; Guinea Pigs; Immune Sera; Injections, Intraperitoneal; Injections, Intravenous; Male; Mercaptopurine; Oxytetracycline; Time Factors

Topics: Anaphylaxis; Animals; Arthus Reaction; DNA; Female; Graft vs Host Reaction; Hypersensitivity, Immediate; Immunosuppressive Agents; Lymph Nodes; Lymphocytes; Mercaptopurine; Mice; Nucleosides; Oxidation-Reduction; Periodic Acid; Purines; Skin Transplantation; Spleen; Thymidine; Thymus Gland; Transplantation, Homologous; Tritium

Topics: Allergens; Anaphylaxis; Animal Diseases; Animals; Asthma; Blood Cell Count; Dogs; Mercaptopurine; Pollen; Skin Tests

Topics: Anaphylaxis; Animals; Antibody Formation; Cellulose; Centrifugation, Density Gradient; Chromatography; Hemagglutination Tests; Immunization Schedule; Immunoglobulin G; Immunoglobulin M; Mercaptopurine; Passive Cutaneous Anaphylaxis; Rabbits; Splenectomy; Ultracentrifugation

Topics: Anaphylaxis; Animals; Chloramphenicol; Dactinomycin; Dextrans; Edema; Emetine; Female; Ileum; Inflammation; Mannomustine; Mercaptopurine; Muscle Contraction; p-Methoxy-N-methylphenethylamine; Rats; Serotonin; Uterus

Topics: Anaphylaxis; Animals; Antibody Formation; Cyclophosphamide; Depression, Chemical; Guinea Pigs; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Mice; Rats; Species Specificity; Thioguanine; Thiophenes

Topics: Anaphylaxis; Animals; Azathioprine; Cortisone; Cyclopentanes; Cyclophosphamide; Encephalomyelitis, Autoimmune, Experimental; Immunosuppressive Agents; Mercaptopurine; Methotrexate; Rats; Thioguanine

Topics: Anaphylaxis; Animals; Antibody Formation; Antigen-Antibody Reactions; Antigens; Chloroquine; Guinea Pigs; Hemolysin Proteins; Lagomorpha; Mercaptopurine; Mice; Pharmacology; Rabbits; Research

Topics: Albumins; Anaphylaxis; Animals; Antibodies; Antibody Formation; Hypersensitivity, Delayed; Lagomorpha; Mercaptopurine; Pharmacology; Rabbits; Research; Serum Albumin