mercaptopurine and Acute-Kidney-Injury

mercaptopurine has been researched along with Acute-Kidney-Injury* in 9 studies

Reviews

1 review(s) available for mercaptopurine and Acute-Kidney-Injury

ArticleYear
Diagnosis and treatment of pure red cell aplasia.
    The Medical clinics of North America, 1976, Volume: 60, Issue:5

    Pure red cell aplasia is a selective aplasia of the marrow erythroid cells. Unlike aplastic anemia, the marrow has a normal cellularity and the patients generally have normal leukocyte and platelet blood counts. The congenital form of the disease occurs in the firlst 1 1/2 years of life and is often responsive to corticosteroids. The acquired form may be secondary to infections, drugs, chemicals, or hemolytic anemia (aplastic crisis). In these cases it is often acute and self-limited with cessation of the infection or drug ingestion. It may also be secondary to systemic lupus erythematosus, rheumatoid arthritis, acute severe renal failure, severe nutritional deficiency, or diverse neoplasms, and may remit with treatment of the primary condition. When a thymoma is present, it should be resected since a remission is produced in 29 per cent of these patients. The remaining patients have an acquired primary form of the disease that tends to be chronic and in some cases may have an immune pathogenesis. A cytotoxic immunoglobulin inhibitor of the marrow erythroid cells or erythropoietin has been described and these patients may respond to prednisone and/or to cytotoxic immunosuppressive drugs such as cyclophosphamide and 6-mercaptopurine. Pure red cell aplasia appears to be more common than the literature has revealed and has stimulated much investigation into an immune pathogenesis for marrow failure.

    Topics: Acute Kidney Injury; Anemia, Aplastic; Antilymphocyte Serum; Arthritis, Rheumatoid; Blood Cell Count; Blood Transfusion; Cyclophosphamide; Deficiency Diseases; Erythropoietin; Humans; Immune System Diseases; Infections; Lupus Erythematosus, Systemic; Mercaptopurine; Prednisone; Remission, Spontaneous; Splenectomy; Thymoma; Thymus Neoplasms

1976

Other Studies

8 other study(ies) available for mercaptopurine and Acute-Kidney-Injury

ArticleYear
[Cutaneous involvement in T-lymphoblastic lymphoma].
    Annales de dermatologie et de venereologie, 2017, Volume: 144, Issue:4

    Lymphoblastic lymphoma (LBL) is a rare form of non-Hodgkin's lymphoma (NHL). Cutaneous LBL is seen in less than 20% of patients.. Herein, we report the case of a 66-year-old male patient without any previous disease history of note and who was presenting a gradually spreading tumoral lesion of the scalp, several purplish macules and nodules on the trunk, and a single spinal adenopathy. A thoracic-abdominal-pelvic CT scan performed for acute renal failure, revealed extensive infiltration of retroperitoneal tissue. Skin biopsies and staging tests indicated LBL-T with associated cutaneous, bone and lymph node retroperitoneal lesions with no mediastinal mass. After two months of treatment with CHOP (four courses), the cutaneous lesions and abdominal tumoral mass had regressed and renal function had returned to normal.. There have been 13 reported cases of LBL with cutaneous involvement; most of these patients were young (under 30 years) and presented multiple cutaneous lesions (nodules or tumors) associated with numerous peripheral adenopathies, invasion of the bone marrow, and in many cases, a mediastinal mass. The clinical presentation of LBL-T in our case is novel on account of the cutaneous sites, associated with abdominal tumoral syndrome, without mediastinal infiltration, and with a single peripheral adenopathy, in an elderly subject.

    Topics: Acute Kidney Injury; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone and Bones; Cyclophosphamide; Doxorubicin; Humans; Immunophenotyping; Leukemic Infiltration; Lymph Nodes; Male; Mercaptopurine; Methotrexate; Organ Specificity; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Retroperitoneal Space; Skin; Vincristine

2017
A 30-month-old child with acute renal failure due to primary renal cytotoxic T-cell lymphoma.
    The American journal of surgical pathology, 2010, Volume: 34, Issue:7

    We present a case of a 30-month-old child who presented with anemia and acute renal failure, and was found to have bilateral renal involvement by primary cytotoxic T-cell lymphoma. This was characterized by a monotonous interstitial lymphoid infiltrate with extensive necrosis. The tumor cells showed a CD8, granzyme, and TIA1-positive phenotype with no evidence of Epstein-Barr virus by in situ hybridization. The differential diagnosis based on the biopsy findings included a reactive interstitial nephritis; however, molecular studies confirmed T-cell clonality. She was started on induction chemotherapy and subsequently received maintenance therapy with methotrexate and 6-mercaptopurine. The patient had a complete response after chemotherapy and at 21 months of follow-up, she has no evidence of residual lymphoma; however, she has developed a dilated cardiomyopathy and she remains in renal failure. We discuss the morphologic, immunophenotypic, and molecular features of our case and describe the clinical course of our patient. We review the literature on primary renal lymphoma with an emphasis on T-lineage lymphomas and those that occur in children.

    Topics: Acute Kidney Injury; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cardiomyopathy, Dilated; Child, Preschool; Clone Cells; Female; Humans; Kidney Neoplasms; Lymphoma, T-Cell, Peripheral; Mercaptopurine; Methotrexate; Remission Induction; T-Lymphocytes, Cytotoxic

2010
Tumor lysis syndrome in an infant with Langerhans cell histiocytosis successfully treated using continuous arteriovenous hemofiltration.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:2

    Langerhans cell histiocytosis (LCH) is an enigmatic disease usually occurring in children. Tumor lysis syndrome (TLS) is a clinical syndrome associated with severe metabolic derangement and oliguric acute renal failure. In this report, we present the clinical course of an infant with advanced LCH who had TLS develop after chemotherapy. Treatment with continuous arteriovenous hemofiltration resulted in effective control of serum uric acid, potassium, creatinine, phosphorus, and blood urea nitrogen levels in the blood.

    Topics: Acute Kidney Injury; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Blood Transfusion; Combined Modality Therapy; Disease Progression; Etoposide; Fatal Outcome; Female; Fluid Therapy; Hemofiltration; Histiocytosis, Langerhans-Cell; Humans; Infant; L-Lactate Dehydrogenase; Lymph Nodes; Mercaptopurine; Multiple Organ Failure; Neck; Orbital Diseases; Prednisolone; Sodium Bicarbonate; Temporal Bone; Tumor Lysis Syndrome; Uric Acid; Vinblastine; Vincristine

2001
Oral Fusarium infection in a granulocytopenic patient with acute myelogenous leukemia: a case report.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1995, Volume: 24, Issue:5

    The fungus Fusarium moniliforme causes fusariosis, which can be invasive and fatal in immunocompromised patients. We report a case of oral Fusarium infection in a granulocytopenic patient with acute myelogenous leukemia who developed necrotic ulceration of the gingiva, extending to the alveolar bone, but was otherwise free of any active systemic lesions. Fusarium moniliforme was identified, by histopathology and culture, to be present in the lesion and was deduced to be the causative organism for this invasive oral infection.

    Topics: Acute Kidney Injury; Aged; Agranulocytosis; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Epirubicin; Etoposide; Fatal Outcome; Fusarium; Gingival Diseases; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Male; Maxillary Diseases; Mercaptopurine; Mycoses; Necrosis; Prednisolone; Ulcer; Vindesine

1995
Hyperuricemia complicating leukemia: treatment with allopurinol and dialysis.
    Archives of internal medicine, 1969, Volume: 123, Issue:2

    Topics: Acetazolamide; Acute Kidney Injury; Adult; Allopurinol; Anuria; Bicarbonates; Blood Gas Analysis; Blood Urea Nitrogen; Carbon Dioxide; Cystoscopy; Electroencephalography; Eye Manifestations; Female; Humans; Leukemia, Lymphoid; Leukocytosis; Mannitol; Mercaptopurine; Methotrexate; Peritoneal Dialysis; Prednisone; Splenomegaly; Thrombocytopenia; Uric Acid; Urinary Catheterization; Vincristine; Water-Electrolyte Balance

1969
Mercaptopurine hepatotoxicity in a patient with chronic active hepatitis.
    Archives of internal medicine, 1967, Volume: 120, Issue:6

    Topics: Acute Kidney Injury; Adolescent; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Creatinine; Female; gamma-Globulins; Hepatitis; Humans; Hyperbilirubinemia; Kidney; Liver; Mercaptopurine; Serum Albumin; Serum Globulins

1967
EXPERIENCE WITH 45 RENAL HOMOTRANSPLANTATIONS IN MAN.
    Lancet (London, England), 1965, May-08, Volume: 1, Issue:7393

    Topics: Acute Kidney Injury; Azathioprine; Cobalt Isotopes; Drug Therapy; Immune Tolerance; Immunosuppressive Agents; Kidney Transplantation; Mercaptopurine; Pathology; Postoperative Complications; Radiation Effects; Renal Insufficiency; Statistics as Topic; Toxicology; Transplantation Immunology; Transplantation, Homologous

1965
ACUTE URIC ACID NEPHROPATHY IN LEUKEMIA. REPORT OF A CASE TREATED WITH PERITONEAL DIALYSIS.
    Archives of internal medicine, 1964, Volume: 113

    Topics: Acute Kidney Injury; Adolescent; Blood; Dialysis; Humans; Kidney Diseases; Leukemia; Mercaptopurine; Metabolism; Methotrexate; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency; Toxicology; Uric Acid; Urine

1964