Page last updated: 2024-10-21

mercaptoethanol and Urinary Tract Diseases

mercaptoethanol has been researched along with Urinary Tract Diseases in 5 studies

Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.

Research Excerpts

ExcerptRelevanceReference
"A randomized study in 20 patients with cancer was carried out to test the clinical efficacy of sodium-2-mercaptoethane sulfonate (ASTA D-7093; mesnum) as an agent to prevent urotoxic side effects (in particular, hemorrhagic cystitis) during cytostatic therapy with the oxazaphosphorines cyclophosphamide and ifosfamide."2.65Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results. ( Brock, N; Burkert, H; Günther, U; Hoefer-Janker, H; Klein, HO; Mitrenga, D; Scheef, W; Schnitker, J; Voigtmann, R, 1979)
"One hundred and forty-six patients with advanced malignant disease were treated with 6 different dosage schedules of ifosfamide (IFX)."1.28Ifosfamide and mesna in the treatment of malignant disease mesna as urothelial protector. ( Falkson, CI; Falkson, G; Falkson, HC, 1989)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19904 (80.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brock, N2
Schnitker, J2
Scheef, W1
Klein, HO1
Burkert, H1
Günther, U1
Hoefer-Janker, H1
Mitrenga, D1
Voigtmann, R1
Holoye, PY1
Glisson, BS1
Lee, JS1
Dhingra, HM1
Murphy, WK1
Umsawasdi, T1
Levy, JK1
Jeffries, D1
Raber, MN1
Hong, WK1
Falkson, CI1
Falkson, HC1
Falkson, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase Ⅱ Randomized Clinical Trial Comparing Vinorelbine-ifosfamide With Gefitinib as Third-line Treatment in Advanced EGFR Gene Mutation Negative Non-small Cell Lung Cancer Patients[NCT01749072]Phase 2120 participants (Anticipated)Interventional2012-12-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for mercaptoethanol and Urinary Tract Diseases

ArticleYear
[Uroprotection with mesna in the chemotherapy of malignant tumors with oxazaphosphorines. Biometric evaluation of a sequential clinical study].
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:10

    Topics: Hematuria; Humans; Mercaptoethanol; Mesna; Phosphoramide Mustards; Urologic Diseases

1982
Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Clinical Trials as Topic; Cystitis; Drug Therapy, Combination; Hematuria; Humans; Male; Mercaptoetha

1979

Other Studies

3 other studies available for mercaptoethanol and Urinary Tract Diseases

ArticleYear
The development of mesna for the inhibition of urotoxic side effects of cyclophosphamide, ifosfamide, and other oxazaphosphorine cytostatics.
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1980, Volume: 74

    Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cystitis; Erythrocyte Count; Ifosfamide; Mercaptoe

1980
Ifosfamide with mesna uroprotection in the management of lung cancer.
    American journal of clinical oncology, 1990, Volume: 13, Issue:2

    Topics: Aged; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Female; Humans

1990
Ifosfamide and mesna in the treatment of malignant disease mesna as urothelial protector.
    Investigational new drugs, 1989, Volume: 7, Issue:2-3

    Topics: Adult; Aged; Drug Therapy, Combination; Female; Humans; Ifosfamide; Male; Mercaptoethanol; Mesna; Mi

1989