mercaptoethanol has been researched along with Sarcoma in 10 studies
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "European and American investigators have reported response rates of 38% to 83% for ifosfamide alone in pretreated sarcomas." | 9.06 | Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma. ( Antman, KH; Elias, A; Grier, HE; Ryan, L; Sherman, D, 1989) |
| "In a phase II study, 42 patients with advanced soft-tissue sarcoma were treated with ifosfamide by 24-h infusion and mesna by 4-h IV bolus, repeated every 3 weeks." | 7.66 | High-dose alkylation therapy using ifosfamide infusion with mesna in the treatment of adult advanced soft-tissue sarcoma. ( Gowing, NF; Harper, PG; Kaye, SB; Mooney, CA; Parsons, CA; Stuart-Harris, RC; Wiltshaw, E, 1983) |
| "Mesna is a sulfhydryl compound that reacts with the metabolites of cyclophosphamide that are excreted in the urine and may produce bladder wall irritation." | 5.27 | Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis. ( Luce, JK; Simons, JA, 1988) |
| "European and American investigators have reported response rates of 38% to 83% for ifosfamide alone in pretreated sarcomas." | 5.06 | Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma. ( Antman, KH; Elias, A; Grier, HE; Ryan, L; Sherman, D, 1989) |
| "In a phase II study, 42 patients with advanced soft-tissue sarcoma were treated with ifosfamide by 24-h infusion and mesna by 4-h IV bolus, repeated every 3 weeks." | 3.66 | High-dose alkylation therapy using ifosfamide infusion with mesna in the treatment of adult advanced soft-tissue sarcoma. ( Gowing, NF; Harper, PG; Kaye, SB; Mooney, CA; Parsons, CA; Stuart-Harris, RC; Wiltshaw, E, 1983) |
| "Body weights were lower in animals kept in cigarette smoke and differences in organ indices could be observed, too." | 1.28 | Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters. ( Beregi, E; Boross, M; Pénzes, L; Rajczy, K; Regius, O, 1991) |
| "Ifosfamide/mesna has activity in a wide range of gynecologic malignancies." | 1.28 | Early phase II Gynecologic Oncology Group experience with ifosfamide/mesna in gynecologic malignancies. ( Berman, ML; Blessing, JA; Homesley, HD; Photopulos, G; Sutton, GP, 1990) |
| "Mesna is a sulfhydryl compound that reacts with the metabolites of cyclophosphamide that are excreted in the urine and may produce bladder wall irritation." | 1.27 | Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis. ( Luce, JK; Simons, JA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stuart-Harris, R | 1 |
| Harper, PG | 2 |
| Kaye, SB | 2 |
| Wiltshaw, E | 2 |
| Stuart-Harris, RC | 1 |
| Parsons, CA | 1 |
| Mooney, CA | 1 |
| Gowing, NF | 1 |
| Beregi, E | 1 |
| Regius, O | 1 |
| Rajczy, K | 1 |
| Boross, M | 1 |
| Pénzes, L | 1 |
| Sutton, GP | 1 |
| Blessing, JA | 1 |
| Photopulos, G | 1 |
| Berman, ML | 1 |
| Homesley, HD | 1 |
| Antman, KH | 1 |
| Ryan, L | 1 |
| Elias, A | 1 |
| Sherman, D | 1 |
| Grier, HE | 1 |
| Pratt, CB | 1 |
| Douglass, EC | 1 |
| Etcubanas, E | 1 |
| Goren, MP | 1 |
| Green, AA | 1 |
| Hayes, FA | 1 |
| Horowitz, ME | 1 |
| Meyer, WH | 1 |
| Thompson, EI | 1 |
| Wilimas, JA | 1 |
| Willemse, PH | 1 |
| de Vries, EG | 1 |
| Cantwell, BM | 2 |
| Harris, AL | 2 |
| Carmichael, J | 1 |
| Ghani, S | 1 |
| Luce, JK | 1 |
| Simons, JA | 1 |
1 trial available for mercaptoethanol and Sarcoma
| Article | Year |
|---|---|
Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clinical Trials as Topic; Female; Hematuria; Human | 1989 |
9 other studies available for mercaptoethanol and Sarcoma
| Article | Year |
|---|---|
High-dose ifosfamide by infusion with mesna in advanced soft tissue sarcoma.
Topics: Adolescent; Adult; Aged; Cyclophosphamide; Female; Humans; Ifosfamide; Male; Mercaptoethanol; Mesna; | 1983 |
High-dose alkylation therapy using ifosfamide infusion with mesna in the treatment of adult advanced soft-tissue sarcoma.
Topics: Adolescent; Adult; Aged; Cyclophosphamide; Drug Evaluation; Drug Therapy, Combination; Female; Human | 1983 |
Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters.
Topics: Aging; Amyloidosis; Animals; Body Weight; Carcinoma, Hepatocellular; Drug Administration Schedule; E | 1991 |
Early phase II Gynecologic Oncology Group experience with ifosfamide/mesna in gynecologic malignancies.
Topics: Antineoplastic Agents; Carcinoma; Drug Evaluation; Female; Humans; Ifosfamide; Mercaptoethanol; Mesn | 1990 |
Clinical studies of ifosfamide/mesna at St Jude Children's Research Hospital, 1983-1988.
Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Humans; Ifosfamide; Infant; Mercaptoethanol; M | 1989 |
Mesna: continuous or bolus infusion?
Topics: Drug Administration Schedule; Humans; Ifosfamide; Infusions, Intravenous; Injections, Intravenous; M | 1989 |
Ifosfamide/mesa and encephalopathy.
Topics: Brain Diseases; Carcinoma, Small Cell; Cyclophosphamide; Female; Humans; Ifosfamide; Lung Neoplasms; | 1985 |
A phase II study of ifosfamide/mesna with doxorubicin for adult soft tissue sarcoma.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain; Doxorubicin; Drug Ev | 1988 |
Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis.
Topics: Adolescent; Adult; Child; Cyclophosphamide; Cystitis; Cystoscopy; Female; Hematuria; Humans; Male; M | 1988 |