mercaptoethanol has been researched along with Cystitis in 26 studies
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
Cystitis: Inflammation of the URINARY BLADDER, either from bacterial or non-bacterial causes. Cystitis is usually associated with painful urination (dysuria), increased frequency, urgency, and suprapubic pain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic cystitis in marrow transplant recipients." | 9.05 | Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study. ( Gordon, MY; Gordon-Smith, EC; Hows, JM; Mehta, A; Perez, R; Ward, L; Woods, K, 1984) |
| "We examined the possibility of continuing oxazaphosphorine therapy in patients with previously documented cyclophosphamide- or ifosfamide-induced hematuria by concomitant use of the uroprotective agent, mesna." | 7.67 | The efficacy of mesna (2-mercaptoethane sodium sulfonate) as a uroprotectant in patients with hemorrhagic cystitis receiving further oxazaphosphorine chemotherapy. ( Andriole, GL; Arasi, V; Linehan, M; Magrath, IT; Miser, JS; Sandlund, JT, 1987) |
| "Mesna is a sulfhydryl compound that reacts with the metabolites of cyclophosphamide that are excreted in the urine and may produce bladder wall irritation." | 5.27 | Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis. ( Luce, JK; Simons, JA, 1988) |
| "A prospective randomised study was carried out to compare the effect of mesna (2-mercaptoethane sulphonate sodium) with that of forced diuresis in preventing cyclophosphamide induced haemorrhagic cystitis in marrow transplant recipients." | 5.05 | Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study. ( Gordon, MY; Gordon-Smith, EC; Hows, JM; Mehta, A; Perez, R; Ward, L; Woods, K, 1984) |
| "We examined the possibility of continuing oxazaphosphorine therapy in patients with previously documented cyclophosphamide- or ifosfamide-induced hematuria by concomitant use of the uroprotective agent, mesna." | 3.67 | The efficacy of mesna (2-mercaptoethane sodium sulfonate) as a uroprotectant in patients with hemorrhagic cystitis receiving further oxazaphosphorine chemotherapy. ( Andriole, GL; Arasi, V; Linehan, M; Magrath, IT; Miser, JS; Sandlund, JT, 1987) |
| "Urotoxic side effects, especially hemorrhagic cystitis, have so far been a limiting factor in the therapeutic use of cyclophosphamide (Endoxan), ifosfamide (Holoxan), and trofosfamide (Ixoten)." | 3.66 | Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds. ( Brock, N; Pohl, J; Stekar, J, 1981) |
| "A randomized study in 20 patients with cancer was carried out to test the clinical efficacy of sodium-2-mercaptoethane sulfonate (ASTA D-7093; mesnum) as an agent to prevent urotoxic side effects (in particular, hemorrhagic cystitis) during cytostatic therapy with the oxazaphosphorines cyclophosphamide and ifosfamide." | 2.65 | Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results. ( Brock, N; Burkert, H; Günther, U; Hoefer-Janker, H; Klein, HO; Mitrenga, D; Scheef, W; Schnitker, J; Voigtmann, R, 1979) |
| "Mesna is a sulfhydryl compound that reacts with the metabolites of cyclophosphamide that are excreted in the urine and may produce bladder wall irritation." | 1.27 | Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis. ( Luce, JK; Simons, JA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (96.15) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brock, N | 5 |
| Pohl, J | 3 |
| Blacklock, H | 1 |
| Ball, L | 1 |
| Knight, C | 1 |
| Schey, S | 1 |
| Prentice, G | 1 |
| Hows, J | 1 |
| Mehta, A | 2 |
| Gordon-Smith, EC | 2 |
| Ehrlich, RM | 3 |
| Freedman, A | 2 |
| Goldsobel, AB | 2 |
| Stiehm, ER | 2 |
| Ljung, BM | 1 |
| Hows, JM | 1 |
| Ward, L | 1 |
| Woods, K | 1 |
| Perez, R | 1 |
| Gordon, MY | 1 |
| Stekar, J | 1 |
| Czownicki, Z | 1 |
| Utracka-Hutka, B | 1 |
| Possinger, K | 1 |
| Ehrhart, H | 1 |
| Misera, C | 1 |
| Hartenstein, R | 1 |
| Link, H | 1 |
| Neef, V | 1 |
| Niethammer, D | 1 |
| Wilms, K | 1 |
| Scheef, W | 1 |
| Klein, HO | 1 |
| Burkert, H | 1 |
| Günther, U | 1 |
| Hoefer-Janker, H | 1 |
| Mitrenga, D | 1 |
| Schnitker, J | 1 |
| Voigtmann, R | 1 |
| Marti, C | 1 |
| Steiner, R | 1 |
| Viollier, AF | 1 |
| Jodal, U | 1 |
| Iwasaku-Fujimoto, M | 1 |
| Fujiwara, F | 1 |
| Todo, S | 1 |
| Morioka, Y | 1 |
| Imashuku, S | 1 |
| Garrick, CL | 1 |
| Cronin, SM | 1 |
| Sensenbrenner, LL | 1 |
| Sakurai, M | 1 |
| Saijo, N | 1 |
| Shinkai, T | 1 |
| Eguchi, K | 1 |
| Sasaki, Y | 1 |
| Tamura, T | 1 |
| Sano, T | 1 |
| Suemasu, K | 1 |
| Jett, JR | 1 |
| Grañena, A | 1 |
| Gardella, S | 1 |
| Marín, P | 1 |
| Carreras, E | 1 |
| Montserrat, E | 1 |
| Rozman, C | 1 |
| Andriole, GL | 1 |
| Sandlund, JT | 1 |
| Miser, JS | 1 |
| Arasi, V | 1 |
| Linehan, M | 1 |
| Magrath, IT | 1 |
| Themann, H | 1 |
| Oberdorf, E | 1 |
| Shaw, IC | 2 |
| Graham, MI | 1 |
| Luce, JK | 1 |
| Simons, JA | 1 |
| Mendoza, GR | 1 |
1 review available for mercaptoethanol and Cystitis
| Article | Year |
|---|---|
Mesna--a short review.
Topics: Cystitis; Expectorants; Humans; Mercaptoethanol; Mesna; Neoplasms | 1987 |
4 trials available for mercaptoethanol and Cystitis
| Article | Year |
|---|---|
Comparison of mesna with forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplantation: a prospective randomised study.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Colony-Forming Units Assay; | 1984 |
[Clinical evaluation of Mitexan in the prevention of urinary tract complications during treatment with Holoxan].
Topics: Clinical Trials as Topic; Cyclophosphamide; Cystitis; Hematuria; Humans; Ifosfamide; Mercaptoethanol | 1981 |
Controlled clinical studies with an antidote against the urotoxicity of oxazaphosphorines: preliminary results.
Topics: Clinical Trials as Topic; Cystitis; Drug Therapy, Combination; Hematuria; Humans; Male; Mercaptoetha | 1979 |
The protective effect of 2-mercapto-ethane sulfonate (MESNA) on hemorrhagic cystitis induced by high-dose ifosfamide treatment tested by a randomized crossover trial.
Topics: Adult; Aged; Clinical Trials as Topic; Cystitis; Female; Hemorrhage; Humans; Ifosfamide; Lung Neopla | 1986 |
21 other studies available for mercaptoethanol and Cystitis
| Article | Year |
|---|---|
Mesnum and cyclophosphamide cystitis.
Topics: Adult; Cyclophosphamide; Cystitis; Humans; Leukemia, Myeloid, Acute; Male; Mercaptoethanol; Mesna | 1980 |
The development of mesna for regional detoxification.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cystitis; Humans; Inactivation, Metabolic; Kidney; | 1983 |
Experience with mesna in patients receiving allogeneic bone marrow transplants for poor prognostic leukaemia.
Topics: Bone Marrow Transplantation; Child; Child, Preschool; Cyclophosphamide; Cystitis; Female; Hemorrhage | 1983 |
Mesna versus forced diuresis to prevent cyclophosphamide induced haemorrhagic cystitis in marrow transplant patients (preliminary data).
Topics: Bone Marrow Transplantation; Cyclophosphamide; Cystitis; Diuresis; Hemorrhage; Humans; Mercaptoethan | 1983 |
The use of sodium 2-mercaptoethane sulfonate to prevent cyclophosphamide cystitis.
Topics: Bone Marrow Transplantation; Child; Cyclophosphamide; Cystitis; Humans; Immunologic Deficiency Syndr | 1984 |
Prevention of cyclophosphamide cystitis with 2-mercaptoethane sodium sulfonate: a histologic study.
Topics: Animals; Cyclophosphamide; Cystitis; Drug Evaluation, Preclinical; Edema; Male; Mercaptoethanol; Mes | 1984 |
The development of mesna for the inhibition of urotoxic side effects of cyclophosphamide, ifosfamide, and other oxazaphosphorine cytostatics.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Cystitis; Erythrocyte Count; Ifosfamide; Mercaptoe | 1980 |
Detoxification of urotoxic oxazaphosphorines by sulfhydryl compounds.
Topics: Animals; Cyclophosphamide; Cystitis; Female; Ifosfamide; Kidney; Mercaptoethanol; Mesna; Rats; Urina | 1981 |
[Prevention of urotoxic complications during therapy with cytostatics. The problem of the interaction between sodium-II-mercaptoethanesulfonate and cyclophosphamide].
Topics: Animals; Carcinoma 256, Walker; Cyclophosphamide; Cystitis; DNA; Mercaptoethanol; Mesna; Rats | 1981 |
Prophylaxis of haemorrhagic cystitis due to cyclophosphamide-conditioning for bone marrow transplantation.
Topics: Bone Marrow Transplantation; Cyclophosphamide; Cystitis; Humans; Mercaptoethanol; Mesna | 1981 |
[High-dose ifosfamide therapy: systemic use of a mucolytic agent for the reduction of urotoxicity].
Topics: Adult; Cyclophosphamide; Cystitis; Hematuria; Humans; Ifosfamide; Male; Mercaptoethanol; Mesna; Oste | 1979 |
The immune response to urinary tract infections in childhood. I. Serological diagnosis of primary symptomatic infection in girls by indirect hemagglutination.
Topics: Acute Disease; Adolescent; Antibodies; Antigens, Bacterial; Child; Child, Preschool; Cystitis; Esche | 1975 |
[Effects of mesna (2-mercaptoethane sodium sulfonate) in children with malignant disease receiving oxazaphosphorine chemotherapy].
Topics: Bone Neoplasms; Child; Cyclophosphamide; Cystitis; Female; Hematuria; Humans; Ifosfamide; Leukemia; | 1990 |
Effect of mesna on cyclophosphamide.
Topics: Bone Marrow Transplantation; Cyclophosphamide; Cystitis; Drug Interactions; Humans; Immunosuppressio | 1989 |
Ifosfamide and mesna.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cystitis; Hemorrhage; Humans; Ifosfamide; Male; Merc | 1989 |
[Usefulness of 2-mercaptoethanol sodium sulfonate (Mesnum) in the prevention of hemorrhagic cystitis in patients undergoing bone marrow transplantation].
Topics: Anemia, Aplastic; Bone Marrow Transplantation; Cyclophosphamide; Cystitis; Fluid Therapy; Furosemide | 1986 |
The efficacy of mesna (2-mercaptoethane sodium sulfonate) as a uroprotectant in patients with hemorrhagic cystitis receiving further oxazaphosphorine chemotherapy.
Topics: Adolescent; Adult; Child; Child, Preschool; Cyclophosphamide; Cystitis; Female; Hematuria; Hemorrhag | 1987 |
Electron microscopic investigations of the cyclophosphamide-induced lesions of the urinary bladder of the rat and their prevention by mesna.
Topics: Animals; Cyclophosphamide; Cystitis; Cytoplasm; Epithelium; Male; Mercaptoethanol; Mesna; Microscopy | 1987 |
Mesna and oxazaphosphorine cancer chemotherapy.
Topics: Chemical Phenomena; Chemistry; Cyclophosphamide; Cystitis; Humans; Mercaptoethanol; Mesna; Tissue Di | 1987 |
Efficacy of mesna in preventing further cyclophosphamide-induced hemorrhagic cystitis.
Topics: Adolescent; Adult; Child; Cyclophosphamide; Cystitis; Cystoscopy; Female; Hematuria; Humans; Male; M | 1988 |
Bone marrow transplantation for Wiskott-Aldrich syndrome: report of 2 cases with use of 2-mercaptoethane sulfonate.
Topics: Bone Marrow Transplantation; Child; Cyclophosphamide; Cystitis; Humans; Infant; Male; Mercaptoethano | 1985 |