mercaptoethanol has been researched along with Cancer of Lung in 19 studies
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of sodium-2-mercaptoethanesulphonate (Mesna) on urinary bladder cancer induced by N-nitroso-N-butyl-N-(4-hydroxybutyl)amine (BBNOH) was studied in male Sprague-Dawley rats." | 7.67 | Delay of bladder cancer induction in rats treated with N-nitroso-N-butyl-N-(4-hydroxybutyl)amine by administration of sodium-2-mercaptoethanesulfonate (Mesna). ( Habs, M; Schmähl, D; Tacchi, AM, 1984) |
| "The influence of sodium-2-mercaptoethanesulphonate (Mesna) on urinary bladder cancer induced by N-nitroso-N-butyl-N-(4-hydroxybutyl)amine (BBNOH) was studied in male Sprague-Dawley rats." | 3.67 | Delay of bladder cancer induction in rats treated with N-nitroso-N-butyl-N-(4-hydroxybutyl)amine by administration of sodium-2-mercaptoethanesulfonate (Mesna). ( Habs, M; Schmähl, D; Tacchi, AM, 1984) |
| " In this study we evaluated the therapeutic activity of combinations of mesna (2-mercaptoethanesulfonate) with cyclophosphamide or Adriamycin in mice with a variety of transplantable tumors (L1210 and P-388 leukemia, Lewis lung and colon 26 carcinoma, B16 melanoma, and M5076 sarcoma)." | 3.67 | Combinations of mesna with cyclophosphamide or adriamycin in the treatment of mice with tumors. ( Bansal, SK; Bernacki, RJ; Gurtoo, HL, 1987) |
| "Body weights were lower in animals kept in cigarette smoke and differences in organ indices could be observed, too." | 1.28 | Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters. ( Beregi, E; Boross, M; Pénzes, L; Rajczy, K; Regius, O, 1991) |
| "A patient with squamous cell carcinoma of the lung and a serum rheumatoid factor (RF) of 1:1,280 had a positive cerebrospinal fluid (CSF) latex agglutination test (LAT) for cryptococcal antigen, in culture-negative, India-ink-negative CSF." | 1.28 | Failure of dithiothreitol and pronase to reveal a false-positive cryptococcal antigen determination in cerebrospinal fluid. ( Huang, CM; Jungkind, DL; Ost, D; Sachs, MK, 1991) |
| "Ifosfamide and mesna were administered to 77 patients with advanced malignancies." | 1.27 | Prediction of ifosfamide/mesna associated encephalopathy. ( Blackledge, G; Blake, AE; Honigsberger, L; Kelly, KA; Meanwell, CA, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (63.16) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Peta, KT | 1 |
| Durandt, C | 1 |
| van Heerden, MB | 1 |
| Joubert, AM | 1 |
| Pepper, MS | 1 |
| Ambele, MA | 1 |
| Bryant, BM | 1 |
| Jarman, M | 1 |
| Ford, HT | 1 |
| Smith, IE | 1 |
| Banham, S | 1 |
| Soukop, M | 1 |
| Burnett, A | 1 |
| Stevenson, R | 1 |
| Cunningham, D | 1 |
| Tansey, P | 1 |
| Ahmedzai, S | 1 |
| Stack, B | 1 |
| Dorward, A | 1 |
| Lucie, N | 1 |
| Araujo, CE | 1 |
| Tessler, J | 1 |
| Matthiessen, W | 1 |
| Stempinski, E | 1 |
| Göbel, D | 1 |
| Thalmann, U | 1 |
| Tacchi, AM | 1 |
| Schmähl, D | 1 |
| Habs, M | 1 |
| Tanaka, M | 1 |
| Inase, N | 1 |
| Fushimi, K | 1 |
| Ishibashi, K | 1 |
| Ichioka, M | 1 |
| Sasaki, S | 1 |
| Marumo, F | 1 |
| Salnikow, K | 1 |
| Su, W | 1 |
| Blagosklonny, MV | 1 |
| Costa, M | 1 |
| Beregi, E | 1 |
| Regius, O | 1 |
| Rajczy, K | 1 |
| Boross, M | 1 |
| Pénzes, L | 1 |
| Sachs, MK | 1 |
| Huang, CM | 1 |
| Ost, D | 1 |
| Jungkind, DL | 1 |
| Dorr, RT | 1 |
| Holoye, PY | 1 |
| Glisson, BS | 1 |
| Lee, JS | 1 |
| Dhingra, HM | 1 |
| Murphy, WK | 1 |
| Umsawasdi, T | 1 |
| Levy, JK | 1 |
| Jeffries, D | 1 |
| Raber, MN | 1 |
| Hong, WK | 1 |
| Cantwell, BM | 3 |
| Harris, AL | 3 |
| Bozzino, JM | 1 |
| Pooley, J | 1 |
| Sakurai, M | 1 |
| Saijo, N | 1 |
| Shinkai, T | 1 |
| Eguchi, K | 1 |
| Sasaki, Y | 1 |
| Tamura, T | 1 |
| Sano, T | 1 |
| Suemasu, K | 1 |
| Jett, JR | 1 |
| Meanwell, CA | 1 |
| Blake, AE | 1 |
| Kelly, KA | 1 |
| Honigsberger, L | 1 |
| Blackledge, G | 1 |
| Bernacki, RJ | 1 |
| Bansal, SK | 1 |
| Gurtoo, HL | 1 |
| Li, GC | 1 |
| Brock, N | 1 |
| Li, JQ | 1 |
| Guan, ZZ | 1 |
| He, YJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase Ⅱ Randomized Clinical Trial Comparing Vinorelbine-ifosfamide With Gefitinib as Third-line Treatment in Advanced EGFR Gene Mutation Negative Non-small Cell Lung Cancer Patients[NCT01749072] | Phase 2 | 120 participants (Anticipated) | Interventional | 2012-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mercaptoethanol and Cancer of Lung
| Article | Year |
|---|---|
Mitomycin, ifosfamide, and mesna in the treatment of lung cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Humans; Ifosfamide; Lung N | 1990 |
4 trials available for mercaptoethanol and Cancer of Lung
| Article | Year |
|---|---|
Prevention of isophosphamide-induced urothelial toxicity with 2-mercaptoethane sulphonate sodium (mesnum) in patients with advanced carcinoma.
Topics: Acrolein; Carcinoma, Bronchogenic; Clinical Trials as Topic; Cyclophosphamide; Female; Hematuria; Hu | 1980 |
Treatment of ifosfamide-induced urothelial toxicity by oral administration of sodium 2-mercaptoethane sulphonate (MESNA) to patients with inoperable lung cancer.
Topics: Administration, Oral; Adult; Aged; Carcinoma, Squamous Cell; Cyclophosphamide; Drug Therapy, Combina | 1983 |
Experience with 24-h infusions of ifosfamide/mesna in small cell lung cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Drug Evaluation; Humans; Ifos | 1986 |
The protective effect of 2-mercapto-ethane sulfonate (MESNA) on hemorrhagic cystitis induced by high-dose ifosfamide treatment tested by a randomized crossover trial.
Topics: Adult; Aged; Clinical Trials as Topic; Cystitis; Female; Hemorrhage; Humans; Ifosfamide; Lung Neopla | 1986 |
14 other studies available for mercaptoethanol and Cancer of Lung
| Article | Year |
|---|---|
Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model.
Topics: 2-Methoxyestradiol; Animals; Lung Neoplasms; Mammary Neoplasms, Animal; Mercaptoethanol; Mice; Mice, | 2023 |
Treatment of small cell carcinoma of lung with late dosage intensification programmes containing cyclophosphamide and mesna.
Topics: Adult; Aged; Carcinoma, Small Cell; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Lun | 1983 |
Combination chemotherapy with adriamycin, ifosfamide and mesna in extensive-stage non-small cell bronchogenic carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Bronchogenic; Cyclophosphamide; Doxorubic | 1983 |
Delay of bladder cancer induction in rats treated with N-nitroso-N-butyl-N-(4-hydroxybutyl)amine by administration of sodium-2-mercaptoethanesulfonate (Mesna).
Topics: Animals; Body Weight; Butylhydroxybutylnitrosamine; Carcinogens; Drinking; Lung Neoplasms; Male; Mer | 1984 |
Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line.
Topics: Adenocarcinoma; Adrenal Cortex Hormones; Aquaporin 3; Aquaporins; Cell Line; Cycloheximide; Dactinom | 1997 |
Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism.
Topics: Carcinogens; Cell Cycle Proteins; Cell Hypoxia; Cobalt; DNA-Binding Proteins; Endothelium, Vascular; | 2000 |
Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters.
Topics: Aging; Amyloidosis; Animals; Body Weight; Carcinoma, Hepatocellular; Drug Administration Schedule; E | 1991 |
Failure of dithiothreitol and pronase to reveal a false-positive cryptococcal antigen determination in cerebrospinal fluid.
Topics: Aged; Antigens, Fungal; Carcinoma, Squamous Cell; Cryptococcosis; Cryptococcus; Dithiothreitol; Fals | 1991 |
Ifosfamide with mesna uroprotection in the management of lung cancer.
Topics: Aged; Carcinoma, Bronchogenic; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Female; Humans | 1990 |
Ifosfamide/mesa and encephalopathy.
Topics: Brain Diseases; Carcinoma, Small Cell; Cyclophosphamide; Female; Humans; Ifosfamide; Lung Neoplasms; | 1985 |
False-positive ketonuria during ifosfamide and mesna therapy.
Topics: False Positive Reactions; Female; Humans; Ifosfamide; Ketone Bodies; Lung Neoplasms; Male; Mercaptoe | 1986 |
Prediction of ifosfamide/mesna associated encephalopathy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Diseases; Electroencephalography; Female; Huma | 1986 |
Combinations of mesna with cyclophosphamide or adriamycin in the treatment of mice with tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Cyclophosphamide; Doxoru | 1987 |
Ifosfamide and Mesna in advanced malignancies.
Topics: Adult; Aged; Carcinoma, Bronchogenic; Female; Hematuria; Humans; Ifosfamide; Lung Neoplasms; Lymphom | 1988 |