mercaptoethanol has been researched along with Amyotrophic Lateral Sclerosis in 3 studies
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ihara, K | 1 |
| Fujiwara, N | 2 |
| Yamaguchi, Y | 1 |
| Torigoe, H | 1 |
| Wakatsuki, S | 1 |
| Taniguchi, N | 2 |
| Suzuki, K | 2 |
| Leinweber, B | 1 |
| Barofsky, E | 1 |
| Barofsky, DF | 1 |
| Ermilov, V | 1 |
| Nylin, K | 1 |
| Beckman, JS | 1 |
| Nakano, M | 1 |
| Kato, S | 1 |
| Yoshihara, D | 1 |
| Ookawara, T | 1 |
| Eguchi, H | 1 |
3 other studies available for mercaptoethanol and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Structural switching of Cu,Zn-superoxide dismutases at loop VI: insights from the crystal structure of 2-mercaptoethanol-modified enzyme.
Topics: Alkylation; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Crystallography, X-Ray; Cysteine; Hu | 2012 |
Aggregation of ALS mutant superoxide dismutase expressed in Escherichia coli.
Topics: Acetylation; Amino Acid Substitution; Amyotrophic Lateral Sclerosis; Cloning, Molecular; Copper; Esc | 2004 |
Oxidative modification to cysteine sulfonic acid of Cys111 in human copper-zinc superoxide dismutase.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Cysteine; Humans; Hydrogen Peroxide; Lewy | 2007 |