mercaptoethanol has been researched along with Aging in 52 studies
Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recent studies have demonstrated that the aging effects in phosphoglycerate kinase (PGK) may be simulated in vitro by prolonged incubation of the enzyme under nonreducing conditions followed by reduction with excess 2-mercaptoethanol." | 7.67 | Protection of phosphoglycerate kinase against in vitro aging by selective cysteine methylation. ( Cook, LL; Gafni, A, 1988) |
| " Our results demonstrated that the impaired LTP induced by aging could be reversed by acute administration of reductants that can regulate thiol redox status directly, such as dithiothreitol or β-mercaptoethanol, but not by classical anti-oxidants such as vitamin C or trolox." | 3.76 | Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. ( Chen, JG; Fu, H; Hu, ZL; Jin, Y; Long, LH; Ni, L; Wang, F; Wang, JZ; Wu, PF; Wu, WN; Xie, N; Yang, YJ; Yu, DF, 2010) |
| "Recent studies have demonstrated that the aging effects in phosphoglycerate kinase (PGK) may be simulated in vitro by prolonged incubation of the enzyme under nonreducing conditions followed by reduction with excess 2-mercaptoethanol." | 3.67 | Protection of phosphoglycerate kinase against in vitro aging by selective cysteine methylation. ( Cook, LL; Gafni, A, 1988) |
| " Dosage of SRBC had no effect on the antibody titres in line HA; however, the higher dosage elicited greater antibody titres than the lower dosage in line LA." | 1.30 | Antibody transmitting ability of hens from lines of chickens differing in response to SRBC antigen. ( Boa-Amponsem, K; Dunnington, EA; Siegel, PB, 1997) |
| "Body weights were lower in animals kept in cigarette smoke and differences in organ indices could be observed, too." | 1.28 | Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters. ( Beregi, E; Boross, M; Pénzes, L; Rajczy, K; Regius, O, 1991) |
| "2-Mercaptoethanol (2-ME) has a beneficial effect on the mean life span of laboratory rodents." | 1.28 | Effect of 2-mercaptoethanol on posthypoxic and age-related biochemical and behavioural changes in mice and rats. ( Fischer, HD; Jähkel, M; Oehler, J; Pénzes, L; Rostock, A; Rudolph, E; Siegemund, C; Wustmann, C, 1990) |
| "2-Mercaptoethanol (2ME) treatment brought the density of the material of P from old mice back to the levels of young mice." | 1.26 | Disulfide bonds and the structure of the chromatin complex in relation to aging. ( Tam, CF; Tas, S; Walford, RL, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (76.92) | 18.7374 |
| 1990's | 11 (21.15) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, YJ | 1 |
| Wu, PF | 1 |
| Long, LH | 1 |
| Yu, DF | 1 |
| Wu, WN | 1 |
| Hu, ZL | 1 |
| Fu, H | 1 |
| Xie, N | 1 |
| Jin, Y | 1 |
| Ni, L | 1 |
| Wang, JZ | 1 |
| Wang, F | 1 |
| Chen, JG | 1 |
| Hughes, BA | 1 |
| Roth, GS | 1 |
| Pitha, J | 1 |
| Rotzsch, W | 3 |
| Martin, H | 1 |
| Martin, R | 1 |
| Hellthaler, G | 4 |
| Richter, V | 1 |
| Fujiwara, M | 2 |
| Kariyone, AI | 1 |
| Baumgartner, WA | 1 |
| Makinodan, T | 11 |
| Blahd, WH | 1 |
| Heidrick, ML | 2 |
| Hendricks, LC | 1 |
| Cook, DE | 1 |
| Magalhães, J | 1 |
| Pinto, R | 1 |
| Lemos, M | 1 |
| Sá Miranda, MC | 1 |
| Poenaru, L | 1 |
| Albright, JW | 3 |
| Scribner, DJ | 1 |
| Moorhead, JW | 1 |
| Chang, MP | 2 |
| Tanaka, JL | 1 |
| Stosic-Grujicic, S | 1 |
| Yamamoto, EK | 1 |
| Perkins, EH | 1 |
| Strehler, BL | 2 |
| Kay, MM | 1 |
| Taylor, SA | 1 |
| Price, RG | 1 |
| Tas, S | 2 |
| Tam, CF | 1 |
| Walford, RL | 1 |
| Dix, MC | 1 |
| Taylor, RL | 1 |
| Boa-Amponsem, K | 1 |
| Dunnington, EA | 1 |
| Siegel, PB | 1 |
| Kishimoto, S | 1 |
| Heller, DE | 1 |
| Friedman, AR | 1 |
| Callard, RE | 1 |
| Boyer, KM | 1 |
| Cherry, JD | 1 |
| Welliver, RC | 1 |
| Dudley, JP | 1 |
| Deseda-Tous, J | 1 |
| Zahradnik, JM | 1 |
| Krause, PJ | 1 |
| Spencer, MJ | 1 |
| Bryson, YJ | 1 |
| Garakian, AJ | 1 |
| Chorpenning, FW | 1 |
| Bolton, RW | 1 |
| Frederick, GT | 1 |
| Rozmiarek, H | 1 |
| Fettback, G | 1 |
| Reifegerste, D | 2 |
| Köhler, R | 1 |
| Pike, BL | 1 |
| Shuttleworth, CA | 1 |
| Forrest, L | 1 |
| Albrecht, V | 1 |
| Pénzes, L | 6 |
| Petzke, KJ | 1 |
| Hoppe, K | 1 |
| Beregi, E | 2 |
| Regius, O | 2 |
| Rajczy, K | 1 |
| Boross, M | 1 |
| Clerch, LB | 1 |
| Massaro, D | 1 |
| Zhou, JQ | 1 |
| Gafni, A | 2 |
| Fischer, HD | 2 |
| Wustmann, C | 2 |
| Rudolph, E | 2 |
| Oehler, J | 2 |
| Jähkel, M | 2 |
| Rostock, A | 2 |
| Siegemund, C | 2 |
| Franklin, RA | 2 |
| Arkins, S | 2 |
| Kelley, KW | 2 |
| Li, YM | 1 |
| Fehér, E | 1 |
| Belsito, DV | 1 |
| Epstein, SP | 1 |
| Schultz, JM | 1 |
| Baer, RL | 1 |
| Thorbecke, GJ | 1 |
| Fong, TC | 1 |
| Hirayama, R | 1 |
| Cook, LL | 1 |
| Noble, RC | 1 |
| Imre, S | 1 |
| Izsák, J | 1 |
| Zoler, ML | 1 |
| Rivas, AJ | 1 |
| Kondracki, E | 1 |
| Machado, I | 1 |
| Bianco, NE | 1 |
| Bakshy, S | 1 |
| Gershbein, LL | 1 |
| Kitchin, SE | 1 |
| Watts, DC | 1 |
| Moss, BA | 1 |
| Joyce, WG | 1 |
| Ingram, VM | 1 |
| Chiu, JF | 1 |
| Sung, SC | 1 |
| Mathai, CK | 1 |
| Beutler, E | 1 |
| Peterson, WJ | 1 |
3 reviews available for mercaptoethanol and Aging
| Article | Year |
|---|---|
[Gene expression, metabolic regulation and aging].
Topics: Aging; Animals; ATP Citrate (pro-S)-Lyase; DNA-Directed RNA Polymerases; Fatty Acids; Gene Expressio | 1981 |
Age influence on the immune system.
Topics: Aging; Animals; Antibody Formation; Antioxidants; Bone Marrow Transplantation; Diet; Genes; Humans; | 1980 |
Age-related changes in immunologic and hormonal activities.
Topics: Aging; Animals; Cell Differentiation; Dithiothreitol; Hormones; Humans; Immune System; Macrophages; | 1985 |
1 trial available for mercaptoethanol and Aging
| Article | Year |
|---|---|
IgM and IgG antibody responses after immunization of children with inactivated monovalent (A/New Jersey/76) and bivalent (A/New Jersey/76-A/Victoria/75) influenza virus vaccines.
Topics: Adolescent; Aging; Antibodies, Viral; Child; Child, Preschool; Clinical Trials as Topic; Dose-Respon | 1977 |
48 other studies available for mercaptoethanol and Aging
| Article | Year |
|---|---|
Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function.
Topics: Aging; Animals; Dithiothreitol; Hippocampus; Long-Term Potentiation; Male; Mercaptoethanol; Neuronal | 2010 |
Age-related decrease in repair of oxidative damage to surface sulfhydryl groups on rat adipocytes.
Topics: Adipose Tissue; Aging; Animals; Cell Membrane; Dextrans; Male; Mercaptoethanol; Mercury; Rats; Sulfh | 1980 |
Induction of immunoglobulin-secreting cells by 2-mercaptoethanol in in vitro culture of B cells from autoimmune mice.
Topics: Aging; Animals; Antibody-Producing Cells; Autoimmune Diseases; B-Lymphocytes; Cells, Cultured; Dose- | 1984 |
In vivo evaluation of age-associated changes in delayed-type hypersensitivity.
Topics: Aging; Animals; Dinitrofluorobenzene; Hypersensitivity, Delayed; Lymphoma, Large B-Cell, Diffuse; Me | 1980 |
Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice.
Topics: Aging; Animals; Free Radicals; Immunity; Lipid Peroxides; Longevity; Lymphocytes; Male; Mercaptoetha | 1984 |
Age dependency of serum acid phosphatase in controls and Gaucher patients.
Topics: Acid Phosphatase; Adult; Aging; Child; Child, Preschool; Female; Gaucher Disease; Humans; Male; Merc | 1984 |
Restoration of impaired immune functions in aging animals. IV. Action of 2-mercaptoethanol in enhancing age-reduced immune responsiveness.
Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Concanavalin A; Female; Lymphocyte Activation; Ma | 1980 |
Anti-immunoglobulin stimulation of murine lymphocytes. VII. Identification of an age-dependent change in accessory cell function.
Topics: Aging; Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Bone Marrow Cells; Cell Adhesion; Immunog | 1982 |
Restoration of impaired immune functions in aging animals. VI. Differential potentiating effect of 2-mercaptoethanol on young and old murine spleen cells.
Topics: Adjuvants, Immunologic; Aging; Animals; Bone Marrow; Female; Hematopoiesis; In Vitro Techniques; Lym | 1982 |
Requirement of 2-mercaptoethanol for in vitro growth factor production by T cells and vulnerability of the response to age.
Topics: Aging; Animals; Cell Survival; Dose-Response Relationship, Drug; Female; Interleukin-2; Kinetics; Ma | 1982 |
Age-related changes in rat glomerular basement membrane.
Topics: Aging; Amino Acids; Animals; Basement Membrane; Disaccharides; Electrophoresis, Polyacrylamide Gel; | 1982 |
Disulfide bonds and the structure of the chromatin complex in relation to aging.
Topics: Aging; Animals; Cell Fractionation; Cell Nucleus; Centrifugation, Isopycnic; Chromatin; Disulfides; | 1980 |
Differential antibody responses in 6.B major histocompatibility (B) complex congenic chickens.
Topics: Aging; Analysis of Variance; Animals; Antibodies, Bacterial; Brucella abortus; Chickens; Female; Gen | 1996 |
Antibody transmitting ability of hens from lines of chickens differing in response to SRBC antigen.
Topics: Aging; Animals; Antibody Formation; Antigens; Chickens; Erythrocytes; Female; Immunity, Maternally-A | 1997 |
IgE antibody formation and aging. I. Age-related changes in IgE antibody formation and avidity for the DNP-determinant in mice.
Topics: Aging; Animals; Antibody Affinity; Ascaris; Dinitrobenzenes; Epitopes; Female; Hemagglutination Test | 1979 |
The effect of crude bursa of Fabricius extracts on the humoral immune response and its recovery in bursectomized chickens.
Topics: Aging; Animals; Antibody Formation; Bursa of Fabricius; Cattle; Chickens; gamma-Globulins; Mercaptoe | 1979 |
Immune function in aged mice. III. Role of macrophages and effect of 2-mercaptoethanol in the response of spleen cells from old mice to phytohemagglutinin, lipopolysaccharide and allogeneic cells.
Topics: Aging; Animals; Ascitic Fluid; Immunity, Cellular; Immunosuppression Therapy; Lipopolysaccharides; L | 1978 |
Control of immunologic abnormalities associated with aging.
Topics: Aging; Animals; Autoimmune Diseases; Body Temperature Regulation; Bone Marrow Transplantation; Diet; | 1979 |
Restoration of impaired immune functions in aging animals. II. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vitro.
Topics: Age Factors; Aging; Animals; Antibody Formation; Antigens; Cell Survival; Female; Hemolytic Plaque T | 1979 |
Development of cellular and humoral responses to teichoic acid.
Topics: Aging; Animals; Antibody Formation; Chromatography, Gel; Female; Glycerophosphates; Guinea Pigs; Hem | 1979 |
Restoration of impaired immune functions in aging animals. III. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vivo.
Topics: Aging; Animals; Antibody Formation; Erythrocytes; Female; Male; Mercaptoethanol; Mice; Mice, Inbred | 1979 |
[On molecular biology of ageing. 12th communication. Glutathione, SH-reagents, metabolism (author's transl)].
Topics: Aging; Animals; Glutathione; Liver; Mercaptoethanol; Molecular Biology; Oxidation-Reduction; Protein | 1977 |
Involvement of disulfide bonds in the condensed structure of facultative heterochromatin and implications on cellular differentiation and aging.
Topics: Adult; Aging; Cell Differentiation; Cells, Cultured; Cheek; Dithiothreitol; Female; Heterochromatin; | 1978 |
[Molecular biology of aging. Part 9: Age-dependent effects of 2-mercapto-ethanol on protein synthesis in the cell-free system of the rat liver].
Topics: Aging; Animals; Cell-Free System; Female; Leucine; Mercaptoethanol; Microsomes, Liver; Protein Biosy | 1977 |
[On the molecular biology of the ageing. VI. Information. Changes of the protein biosynthesis in the age (author's transl)].
Topics: Aging; Animals; Cytosol; Mercaptoethanol; Mice; Microsomes; Protein Biosynthesis; Rats; Ribosomes; R | 1976 |
A microculture method for the generation of primary immune responses in vitro.
Topics: Aging; Animals; Antigens, Bacterial; Antigens, Heterophile; Cell Count; Cell Separation; Cells, Cult | 1975 |
Changes in guinea-pig dermal collagen during development.
Topics: Aging; Animals; Chromatography, Gel; Collagen; Female; Guinea Pigs; Mercaptoethanol; Molecular Weigh | 1975 |
Relationship between a long-term treatment of 2-mercaptoethanol and protein metabolism in the ageing rat.
Topics: Aging; Animals; Female; Glycine; Kinetics; Mercaptoethanol; Methylhistidines; Nitrogen; Protein Bios | 1992 |
Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters.
Topics: Aging; Amyloidosis; Animals; Body Weight; Carcinoma, Hepatocellular; Drug Administration Schedule; E | 1991 |
Oxidation-reduction-sensitive binding of lung protein to rat catalase mRNA.
Topics: Aging; Animals; Animals, Newborn; Catalase; Lung; Mercaptoethanol; Oxidation-Reduction; Oxygen; Prot | 1992 |
Exposure of rat muscle phosphoglycerate kinase to a nonenzymatic MFO system generates the old form of the enzyme.
Topics: Aging; Animals; Ascorbic Acid; Chlorides; Cysteine; Enzyme Activation; Female; Ferric Compounds; Hot | 1991 |
Effect of 2-mercaptoethanol on posthypoxic and age-related biochemical and behavioural changes in mice and rats.
Topics: Aging; Animals; Behavior, Animal; Brain; Dopamine; Lipid Peroxidation; Male; Malondialdehyde; Mercap | 1990 |
The proliferative response of rat T cells to calcium ionophores increases with age.
Topics: Aging; Animals; Calcimycin; Concanavalin A; Female; Glutathione; Interleukin-2; Interleukin-4; Ionom | 1990 |
Effect of 2-mercapto-ethanol on some brain biochemical characteristics and behavioural changes in the ageing CBA/Ca mice.
Topics: Aging; Animals; Behavior, Animal; Brain; Brain Chemistry; Dopamine; Dopamine Antagonists; Lipid Pero | 1990 |
Glutathione augments in vitro proliferative responses of lymphocytes to concanavalin A to a greater degree in old than in young rats.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Concanavalin A; Cysteine; Female; Glutathione; Kinet | 1990 |
Effect of an antioxidant compound (2-mercaptoethanol) on the nerve terminals of the aging small intestine.
Topics: Aging; Animals; Antioxidants; Intestine, Small; Male; Mercaptoethanol; Mice; Mice, Inbred CBA; Myent | 1990 |
Enhancement by various cytokines or 2-beta-mercaptoethanol of Ia antigen expression on Langerhans cells in skin from normal aged and young mice. Effect of cyclosporine A.
Topics: Adjuvants, Immunologic; Aging; Animals; Biological Factors; Cyclosporins; Cytokines; Epidermis; Fema | 1989 |
Preferential enhancement by 2-mercaptoethanol of IL-2 responsiveness of T blast cells from old over young mice is associated with potentiated protein kinase C translocation.
Topics: Aging; Animals; Biological Transport, Active; In Vitro Techniques; Interleukin-2; Lymphocyte Activat | 1989 |
Protection of phosphoglycerate kinase against in vitro aging by selective cysteine methylation.
Topics: Aging; Animals; Cysteine; Kinetics; Mercaptoethanol; Methylation; Muscle Development; Muscles; Phosp | 1988 |
Effect of 2-mercaptoethanol on some metabolic indices of ageing of CBA/Ca inbred mice.
Topics: Aging; Algorithms; Animals; Fatty Acids; Hot Temperature; Life Expectancy; Lipid Metabolism; Liver; | 1988 |
Free radicals: the real culprits in aging?
Topics: Aging; Animals; Antioxidants; Cell Differentiation; Free Radicals; Humans; Mercaptoethanol; T-Lympho | 1985 |
Proliferative response in solid culture of T cells from healthy aged subjects.
Topics: Adolescent; Adult; Aged; Aging; Cell Survival; Culture Media; Erythrocytes; Humans; Lymphocyte Activ | 1985 |
In vivo depression of hepatic succinoxidase by sulfhydryl compounds.
Topics: Aging; Animals; Castration; Depression, Chemical; Dihydrolipoamide Dehydrogenase; Dimercaprol; Elect | 1971 |
Comparison of adenylate kinase from liver and muscle of normal mice and those with an hereditary muscular dystrophy.
Topics: Adenosine Monophosphate; Aging; Animals; Benzoates; Cattle; Cold Temperature; Dialysis; Drug Stabili | 1974 |
Histones in chick embryonic erythropoiesis.
Topics: Aging; Amino Acids; Animals; Cell Division; Cell Nucleus; Chick Embryo; Chickens; Electrophoresis, P | 1973 |
Solubilization and characterization of a particulate form of DNA polymerase from adult rat brain nuclei.
Topics: Aging; Animals; Brain; Cell Nucleus; Cerebellum; Chromatin; Cytosine Nucleotides; DNA Nucleotidyltra | 1972 |
Biochemical characteristics of galactokinase from adult and fetal human red cells.
Topics: Adenosine Triphosphate; Adult; Aging; Buffers; Carbon Isotopes; Chemical Precipitation; Chromatograp | 1967 |
Further studies on the secondary antibody-forming potential of juvenile, young adult, adult, and aged mice.
Topics: Aging; Animals; Antibody Formation; Cell Division; Erythrocytes; Immunoassay; Mercaptoethanol; Mice; | 1966 |