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mercaptoethanol and Aging

mercaptoethanol has been researched along with Aging in 52 studies

Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Recent studies have demonstrated that the aging effects in phosphoglycerate kinase (PGK) may be simulated in vitro by prolonged incubation of the enzyme under nonreducing conditions followed by reduction with excess 2-mercaptoethanol."7.67Protection of phosphoglycerate kinase against in vitro aging by selective cysteine methylation. ( Cook, LL; Gafni, A, 1988)
" Our results demonstrated that the impaired LTP induced by aging could be reversed by acute administration of reductants that can regulate thiol redox status directly, such as dithiothreitol or β-mercaptoethanol, but not by classical anti-oxidants such as vitamin C or trolox."3.76Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function. ( Chen, JG; Fu, H; Hu, ZL; Jin, Y; Long, LH; Ni, L; Wang, F; Wang, JZ; Wu, PF; Wu, WN; Xie, N; Yang, YJ; Yu, DF, 2010)
"Recent studies have demonstrated that the aging effects in phosphoglycerate kinase (PGK) may be simulated in vitro by prolonged incubation of the enzyme under nonreducing conditions followed by reduction with excess 2-mercaptoethanol."3.67Protection of phosphoglycerate kinase against in vitro aging by selective cysteine methylation. ( Cook, LL; Gafni, A, 1988)
" Dosage of SRBC had no effect on the antibody titres in line HA; however, the higher dosage elicited greater antibody titres than the lower dosage in line LA."1.30Antibody transmitting ability of hens from lines of chickens differing in response to SRBC antigen. ( Boa-Amponsem, K; Dunnington, EA; Siegel, PB, 1997)
"Body weights were lower in animals kept in cigarette smoke and differences in organ indices could be observed, too."1.28Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters. ( Beregi, E; Boross, M; Pénzes, L; Rajczy, K; Regius, O, 1991)
"2-Mercaptoethanol (2-ME) has a beneficial effect on the mean life span of laboratory rodents."1.28Effect of 2-mercaptoethanol on posthypoxic and age-related biochemical and behavioural changes in mice and rats. ( Fischer, HD; Jähkel, M; Oehler, J; Pénzes, L; Rostock, A; Rudolph, E; Siegemund, C; Wustmann, C, 1990)
"2-Mercaptoethanol (2ME) treatment brought the density of the material of P from old mice back to the levels of young mice."1.26Disulfide bonds and the structure of the chromatin complex in relation to aging. ( Tam, CF; Tas, S; Walford, RL, 1980)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199040 (76.92)18.7374
1990's11 (21.15)18.2507
2000's0 (0.00)29.6817
2010's1 (1.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yang, YJ1
Wu, PF1
Long, LH1
Yu, DF1
Wu, WN1
Hu, ZL1
Fu, H1
Xie, N1
Jin, Y1
Ni, L1
Wang, JZ1
Wang, F1
Chen, JG1
Hughes, BA1
Roth, GS1
Pitha, J1
Rotzsch, W3
Martin, H1
Martin, R1
Hellthaler, G4
Richter, V1
Fujiwara, M2
Kariyone, AI1
Baumgartner, WA1
Makinodan, T11
Blahd, WH1
Heidrick, ML2
Hendricks, LC1
Cook, DE1
Magalhães, J1
Pinto, R1
Lemos, M1
Sá Miranda, MC1
Poenaru, L1
Albright, JW3
Scribner, DJ1
Moorhead, JW1
Chang, MP2
Tanaka, JL1
Stosic-Grujicic, S1
Yamamoto, EK1
Perkins, EH1
Strehler, BL2
Kay, MM1
Taylor, SA1
Price, RG1
Tas, S2
Tam, CF1
Walford, RL1
Dix, MC1
Taylor, RL1
Boa-Amponsem, K1
Dunnington, EA1
Siegel, PB1
Kishimoto, S1
Heller, DE1
Friedman, AR1
Callard, RE1
Boyer, KM1
Cherry, JD1
Welliver, RC1
Dudley, JP1
Deseda-Tous, J1
Zahradnik, JM1
Krause, PJ1
Spencer, MJ1
Bryson, YJ1
Garakian, AJ1
Chorpenning, FW1
Bolton, RW1
Frederick, GT1
Rozmiarek, H1
Fettback, G1
Reifegerste, D2
Köhler, R1
Pike, BL1
Shuttleworth, CA1
Forrest, L1
Albrecht, V1
Pénzes, L6
Petzke, KJ1
Hoppe, K1
Beregi, E2
Regius, O2
Rajczy, K1
Boross, M1
Clerch, LB1
Massaro, D1
Zhou, JQ1
Gafni, A2
Fischer, HD2
Wustmann, C2
Rudolph, E2
Oehler, J2
Jähkel, M2
Rostock, A2
Siegemund, C2
Franklin, RA2
Arkins, S2
Kelley, KW2
Li, YM1
Fehér, E1
Belsito, DV1
Epstein, SP1
Schultz, JM1
Baer, RL1
Thorbecke, GJ1
Fong, TC1
Hirayama, R1
Cook, LL1
Noble, RC1
Imre, S1
Izsák, J1
Zoler, ML1
Rivas, AJ1
Kondracki, E1
Machado, I1
Bianco, NE1
Bakshy, S1
Gershbein, LL1
Kitchin, SE1
Watts, DC1
Moss, BA1
Joyce, WG1
Ingram, VM1
Chiu, JF1
Sung, SC1
Mathai, CK1
Beutler, E1
Peterson, WJ1

Reviews

3 reviews available for mercaptoethanol and Aging

ArticleYear
[Gene expression, metabolic regulation and aging].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1981, Volume: 36, Issue:5

    Topics: Aging; Animals; ATP Citrate (pro-S)-Lyase; DNA-Directed RNA Polymerases; Fatty Acids; Gene Expressio

1981
Age influence on the immune system.
    Advances in immunology, 1980, Volume: 29

    Topics: Aging; Animals; Antibody Formation; Antioxidants; Bone Marrow Transplantation; Diet; Genes; Humans;

1980
Age-related changes in immunologic and hormonal activities.
    IARC scientific publications, 1985, Issue:58

    Topics: Aging; Animals; Cell Differentiation; Dithiothreitol; Hormones; Humans; Immune System; Macrophages;

1985

Trials

1 trial available for mercaptoethanol and Aging

ArticleYear
IgM and IgG antibody responses after immunization of children with inactivated monovalent (A/New Jersey/76) and bivalent (A/New Jersey/76-A/Victoria/75) influenza virus vaccines.
    The Journal of infectious diseases, 1977, Volume: 136 Suppl

    Topics: Adolescent; Aging; Antibodies, Viral; Child; Child, Preschool; Clinical Trials as Topic; Dose-Respon

1977

Other Studies

48 other studies available for mercaptoethanol and Aging

ArticleYear
Reversal of aging-associated hippocampal synaptic plasticity deficits by reductants via regulation of thiol redox and NMDA receptor function.
    Aging cell, 2010, Volume: 9, Issue:5

    Topics: Aging; Animals; Dithiothreitol; Hippocampus; Long-Term Potentiation; Male; Mercaptoethanol; Neuronal

2010
Age-related decrease in repair of oxidative damage to surface sulfhydryl groups on rat adipocytes.
    Journal of cellular physiology, 1980, Volume: 103, Issue:2

    Topics: Adipose Tissue; Aging; Animals; Cell Membrane; Dextrans; Male; Mercaptoethanol; Mercury; Rats; Sulfh

1980
Induction of immunoglobulin-secreting cells by 2-mercaptoethanol in in vitro culture of B cells from autoimmune mice.
    Immunology, 1984, Volume: 51, Issue:4

    Topics: Aging; Animals; Antibody-Producing Cells; Autoimmune Diseases; B-Lymphocytes; Cells, Cultured; Dose-

1984
In vivo evaluation of age-associated changes in delayed-type hypersensitivity.
    Mechanisms of ageing and development, 1980, Volume: 12, Issue:3

    Topics: Aging; Animals; Dinitrofluorobenzene; Hypersensitivity, Delayed; Lymphoma, Large B-Cell, Diffuse; Me

1980
Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice.
    Mechanisms of ageing and development, 1984, Oct-31, Volume: 27, Issue:3

    Topics: Aging; Animals; Free Radicals; Immunity; Lipid Peroxides; Longevity; Lymphocytes; Male; Mercaptoetha

1984
Age dependency of serum acid phosphatase in controls and Gaucher patients.
    Enzyme, 1984, Volume: 32, Issue:2

    Topics: Acid Phosphatase; Adult; Aging; Child; Child, Preschool; Female; Gaucher Disease; Humans; Male; Merc

1984
Restoration of impaired immune functions in aging animals. IV. Action of 2-mercaptoethanol in enhancing age-reduced immune responsiveness.
    Mechanisms of ageing and development, 1980, Volume: 13, Issue:4

    Topics: Aging; Animals; Antibody Formation; B-Lymphocytes; Concanavalin A; Female; Lymphocyte Activation; Ma

1980
Anti-immunoglobulin stimulation of murine lymphocytes. VII. Identification of an age-dependent change in accessory cell function.
    Journal of immunology (Baltimore, Md. : 1950), 1982, Volume: 128, Issue:3

    Topics: Aging; Animals; Antibodies, Anti-Idiotypic; B-Lymphocytes; Bone Marrow Cells; Cell Adhesion; Immunog

1982
Restoration of impaired immune functions in aging animals. VI. Differential potentiating effect of 2-mercaptoethanol on young and old murine spleen cells.
    International journal of immunopharmacology, 1982, Volume: 4, Issue:5

    Topics: Adjuvants, Immunologic; Aging; Animals; Bone Marrow; Female; Hematopoiesis; In Vitro Techniques; Lym

1982
Requirement of 2-mercaptoethanol for in vitro growth factor production by T cells and vulnerability of the response to age.
    Mechanisms of ageing and development, 1982, Volume: 20, Issue:1

    Topics: Aging; Animals; Cell Survival; Dose-Response Relationship, Drug; Female; Interleukin-2; Kinetics; Ma

1982
Age-related changes in rat glomerular basement membrane.
    The International journal of biochemistry, 1982, Volume: 14, Issue:3

    Topics: Aging; Amino Acids; Animals; Basement Membrane; Disaccharides; Electrophoresis, Polyacrylamide Gel;

1982
Disulfide bonds and the structure of the chromatin complex in relation to aging.
    Mechanisms of ageing and development, 1980, Volume: 12, Issue:1

    Topics: Aging; Animals; Cell Fractionation; Cell Nucleus; Centrifugation, Isopycnic; Chromatin; Disulfides;

1980
Differential antibody responses in 6.B major histocompatibility (B) complex congenic chickens.
    Poultry science, 1996, Volume: 75, Issue:2

    Topics: Aging; Analysis of Variance; Animals; Antibodies, Bacterial; Brucella abortus; Chickens; Female; Gen

1996
Antibody transmitting ability of hens from lines of chickens differing in response to SRBC antigen.
    British poultry science, 1997, Volume: 38, Issue:5

    Topics: Aging; Animals; Antibody Formation; Antigens; Chickens; Erythrocytes; Female; Immunity, Maternally-A

1997
IgE antibody formation and aging. I. Age-related changes in IgE antibody formation and avidity for the DNP-determinant in mice.
    Journal of immunology (Baltimore, Md. : 1950), 1979, Volume: 123, Issue:1

    Topics: Aging; Animals; Antibody Affinity; Ascaris; Dinitrobenzenes; Epitopes; Female; Hemagglutination Test

1979
The effect of crude bursa of Fabricius extracts on the humoral immune response and its recovery in bursectomized chickens.
    Developmental and comparative immunology, 1979,Fall, Volume: 3, Issue:4

    Topics: Aging; Animals; Antibody Formation; Bursa of Fabricius; Cattle; Chickens; gamma-Globulins; Mercaptoe

1979
Immune function in aged mice. III. Role of macrophages and effect of 2-mercaptoethanol in the response of spleen cells from old mice to phytohemagglutinin, lipopolysaccharide and allogeneic cells.
    European journal of immunology, 1978, Volume: 8, Issue:10

    Topics: Aging; Animals; Ascitic Fluid; Immunity, Cellular; Immunosuppression Therapy; Lipopolysaccharides; L

1978
Control of immunologic abnormalities associated with aging.
    Mechanisms of ageing and development, 1979, Volume: 9, Issue:1-2

    Topics: Aging; Animals; Autoimmune Diseases; Body Temperature Regulation; Bone Marrow Transplantation; Diet;

1979
Restoration of impaired immune functions in aging animals. II. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vitro.
    Mechanisms of ageing and development, 1979, Volume: 10, Issue:5

    Topics: Age Factors; Aging; Animals; Antibody Formation; Antigens; Cell Survival; Female; Hemolytic Plaque T

1979
Development of cellular and humoral responses to teichoic acid.
    Developmental and comparative immunology, 1979,Fall, Volume: 3, Issue:4

    Topics: Aging; Animals; Antibody Formation; Chromatography, Gel; Female; Glycerophosphates; Guinea Pigs; Hem

1979
Restoration of impaired immune functions in aging animals. III. Effect of mercaptoethanol in enhancing the reduced primary antibody responsiveness in vivo.
    Mechanisms of ageing and development, 1979, Volume: 11, Issue:1

    Topics: Aging; Animals; Antibody Formation; Erythrocytes; Female; Male; Mercaptoethanol; Mice; Mice, Inbred

1979
[On molecular biology of ageing. 12th communication. Glutathione, SH-reagents, metabolism (author's transl)].
    Zeitschrift fur Alternsforschung, 1977, Volume: 32, Issue:6

    Topics: Aging; Animals; Glutathione; Liver; Mercaptoethanol; Molecular Biology; Oxidation-Reduction; Protein

1977
Involvement of disulfide bonds in the condensed structure of facultative heterochromatin and implications on cellular differentiation and aging.
    Gerontology, 1978, Volume: 24, Issue:5

    Topics: Adult; Aging; Cell Differentiation; Cells, Cultured; Cheek; Dithiothreitol; Female; Heterochromatin;

1978
[Molecular biology of aging. Part 9: Age-dependent effects of 2-mercapto-ethanol on protein synthesis in the cell-free system of the rat liver].
    Zeitschrift fur Alternsforschung, 1977, Volume: 32, Issue:2

    Topics: Aging; Animals; Cell-Free System; Female; Leucine; Mercaptoethanol; Microsomes, Liver; Protein Biosy

1977
[On the molecular biology of the ageing. VI. Information. Changes of the protein biosynthesis in the age (author's transl)].
    Zeitschrift fur Alternsforschung, 1976, Volume: 31, Issue:2

    Topics: Aging; Animals; Cytosol; Mercaptoethanol; Mice; Microsomes; Protein Biosynthesis; Rats; Ribosomes; R

1976
A microculture method for the generation of primary immune responses in vitro.
    Journal of immunological methods, 1975, Volume: 9, Issue:1

    Topics: Aging; Animals; Antigens, Bacterial; Antigens, Heterophile; Cell Count; Cell Separation; Cells, Cult

1975
Changes in guinea-pig dermal collagen during development.
    Biochemical Society transactions, 1975, Volume: 3, Issue:1

    Topics: Aging; Animals; Chromatography, Gel; Collagen; Female; Guinea Pigs; Mercaptoethanol; Molecular Weigh

1975
Relationship between a long-term treatment of 2-mercaptoethanol and protein metabolism in the ageing rat.
    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 1992, Volume: 162, Issue:6

    Topics: Aging; Animals; Female; Glycine; Kinetics; Mercaptoethanol; Methylhistidines; Nitrogen; Protein Bios

1992
Effect of cigarette smoke and 2-mercaptoethanol administration on age-related alterations and immunological parameters.
    Gerontology, 1991, Volume: 37, Issue:6

    Topics: Aging; Amyloidosis; Animals; Body Weight; Carcinoma, Hepatocellular; Drug Administration Schedule; E

1991
Oxidation-reduction-sensitive binding of lung protein to rat catalase mRNA.
    The Journal of biological chemistry, 1992, Feb-15, Volume: 267, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Catalase; Lung; Mercaptoethanol; Oxidation-Reduction; Oxygen; Prot

1992
Exposure of rat muscle phosphoglycerate kinase to a nonenzymatic MFO system generates the old form of the enzyme.
    Journal of gerontology, 1991, Volume: 46, Issue:6

    Topics: Aging; Animals; Ascorbic Acid; Chlorides; Cysteine; Enzyme Activation; Female; Ferric Compounds; Hot

1991
Effect of 2-mercaptoethanol on posthypoxic and age-related biochemical and behavioural changes in mice and rats.
    Biomedica biochimica acta, 1990, Volume: 49, Issue:10

    Topics: Aging; Animals; Behavior, Animal; Brain; Dopamine; Lipid Peroxidation; Male; Malondialdehyde; Mercap

1990
The proliferative response of rat T cells to calcium ionophores increases with age.
    Cellular immunology, 1990, Oct-15, Volume: 130, Issue:2

    Topics: Aging; Animals; Calcimycin; Concanavalin A; Female; Glutathione; Interleukin-2; Interleukin-4; Ionom

1990
Effect of 2-mercapto-ethanol on some brain biochemical characteristics and behavioural changes in the ageing CBA/Ca mice.
    Pharmacology, 1990, Volume: 40, Issue:6

    Topics: Aging; Animals; Behavior, Animal; Brain; Brain Chemistry; Dopamine; Dopamine Antagonists; Lipid Pero

1990
Glutathione augments in vitro proliferative responses of lymphocytes to concanavalin A to a greater degree in old than in young rats.
    The Journal of nutrition, 1990, Volume: 120, Issue:12

    Topics: Aging; Animals; Cell Division; Cells, Cultured; Concanavalin A; Cysteine; Female; Glutathione; Kinet

1990
Effect of an antioxidant compound (2-mercaptoethanol) on the nerve terminals of the aging small intestine.
    Experimental gerontology, 1990, Volume: 25, Issue:2

    Topics: Aging; Animals; Antioxidants; Intestine, Small; Male; Mercaptoethanol; Mice; Mice, Inbred CBA; Myent

1990
Enhancement by various cytokines or 2-beta-mercaptoethanol of Ia antigen expression on Langerhans cells in skin from normal aged and young mice. Effect of cyclosporine A.
    Journal of immunology (Baltimore, Md. : 1950), 1989, Sep-01, Volume: 143, Issue:5

    Topics: Adjuvants, Immunologic; Aging; Animals; Biological Factors; Cyclosporins; Cytokines; Epidermis; Fema

1989
Preferential enhancement by 2-mercaptoethanol of IL-2 responsiveness of T blast cells from old over young mice is associated with potentiated protein kinase C translocation.
    Immunology letters, 1989, Jan-31, Volume: 20, Issue:2

    Topics: Aging; Animals; Biological Transport, Active; In Vitro Techniques; Interleukin-2; Lymphocyte Activat

1989
Protection of phosphoglycerate kinase against in vitro aging by selective cysteine methylation.
    The Journal of biological chemistry, 1988, Oct-05, Volume: 263, Issue:28

    Topics: Aging; Animals; Cysteine; Kinetics; Mercaptoethanol; Methylation; Muscle Development; Muscles; Phosp

1988
Effect of 2-mercaptoethanol on some metabolic indices of ageing of CBA/Ca inbred mice.
    Mechanisms of ageing and development, 1988, Volume: 45, Issue:1

    Topics: Aging; Algorithms; Animals; Fatty Acids; Hot Temperature; Life Expectancy; Lipid Metabolism; Liver;

1988
Free radicals: the real culprits in aging?
    Geriatrics, 1985, Volume: 40, Issue:3

    Topics: Aging; Animals; Antioxidants; Cell Differentiation; Free Radicals; Humans; Mercaptoethanol; T-Lympho

1985
Proliferative response in solid culture of T cells from healthy aged subjects.
    Gerontology, 1985, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aged; Aging; Cell Survival; Culture Media; Erythrocytes; Humans; Lymphocyte Activ

1985
In vivo depression of hepatic succinoxidase by sulfhydryl compounds.
    Biochemical and biophysical research communications, 1971, Mar-05, Volume: 42, Issue:5

    Topics: Aging; Animals; Castration; Depression, Chemical; Dihydrolipoamide Dehydrogenase; Dimercaprol; Elect

1971
Comparison of adenylate kinase from liver and muscle of normal mice and those with an hereditary muscular dystrophy.
    Biochimica et biophysica acta, 1974, Oct-17, Volume: 364, Issue:2

    Topics: Adenosine Monophosphate; Aging; Animals; Benzoates; Cattle; Cold Temperature; Dialysis; Drug Stabili

1974
Histones in chick embryonic erythropoiesis.
    The Journal of biological chemistry, 1973, Feb-10, Volume: 248, Issue:3

    Topics: Aging; Amino Acids; Animals; Cell Division; Cell Nucleus; Chick Embryo; Chickens; Electrophoresis, P

1973
Solubilization and characterization of a particulate form of DNA polymerase from adult rat brain nuclei.
    Biochimica et biophysica acta, 1972, Mar-24, Volume: 262, Issue:3

    Topics: Aging; Animals; Brain; Cell Nucleus; Cerebellum; Chromatin; Cytosine Nucleotides; DNA Nucleotidyltra

1972
Biochemical characteristics of galactokinase from adult and fetal human red cells.
    Enzymologia, 1967, Oct-31, Volume: 33, Issue:3

    Topics: Adenosine Triphosphate; Adult; Aging; Buffers; Carbon Isotopes; Chemical Precipitation; Chromatograp

1967
Further studies on the secondary antibody-forming potential of juvenile, young adult, adult, and aged mice.
    Developmental biology, 1966, Volume: 14, Issue:1

    Topics: Aging; Animals; Antibody Formation; Cell Division; Erythrocytes; Immunoassay; Mercaptoethanol; Mice;

1966