meprobamate and Drug Withdrawal Symptoms
meprobamate has been researched along with Drug Withdrawal Symptoms in 43 studies
Meprobamate: A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Phenazepam given to rats in a daily dose of 2 mg/kg intraperitoneally for a long (30 days) time ceased to produce the sedative effect, and discontinuation of the medication led to development of the so-called "recoil syndrome" characterized by general depression and disturbances of the conditioned-reflex activity." | 3.66 | [Experimental study of the "'rebound syndrome" following discontinuation of prolonged phenazepam administration and possibilities for preventing it]. ( Garibova, TL; Voronina, TA, 1981) |
"Carisoprodol is a centrally acting muscle relaxant used in the treatment of various musculoskeletal disorders whose main metabolite, meprobamate, is a controlled substance in the United States due to its sedative properties and potential for abuse." | 1.36 | Carisoprodol withdrawal after internet purchase. ( Agrwal, N; Eleid, MF; Goodman, BP; Krahn, LE, 2010) |
"Carisoprodol is a commonly used centrally acting muscle relaxant." | 1.34 | Is the frequency of carisoprodol withdrawal syndrome increasing? ( Hammer, JS; Pendarvis, RO; Reeves, RR, 2007) |
" Rats were treated orally with MPB (maintenance dosage = 800 mg/kg X 2/day), PHB (100 X 2) or COD (50 X 2) twice a day (10:00 a." | 1.27 | Physical dependence on meprobamate after repeated oral administration in rats. ( Nakamura, H; Shimizu, M, 1983) |
Research
Studies (43)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 36 (83.72) | 18.7374 |
1990's | 3 (6.98) | 18.2507 |
2000's | 2 (4.65) | 29.6817 |
2010's | 2 (4.65) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
James, AO | 1 |
Nicholson, TR | 1 |
Hill, R | 1 |
Bearn, J | 1 |
Eleid, MF | 1 |
Krahn, LE | 1 |
Agrwal, N | 1 |
Goodman, BP | 1 |
SNOW, L | 1 |
RICKELS, K | 2 |
MCCORMICK, TC | 1 |
BERLE, BB | 1 |
NYSWANDER, M | 1 |
SOULAIRAC, A | 1 |
GEIER, S | 1 |
GIBBS, FA | 1 |
GEORGE, WK | 1 |
STUBBS, JB | 1 |
DILLE, JR | 1 |
TANG, PC | 1 |
FLYNN, SF | 1 |
HOLLISTER, LE | 1 |
GLAZENER, FS | 1 |
Reeves, RR | 1 |
Hammer, JS | 1 |
Pendarvis, RO | 1 |
Ewing, JA | 1 |
Bakewell, WE | 1 |
Modell, JG | 1 |
Lenox, RH | 1 |
Nakamura, H | 1 |
Shimizu, M | 1 |
Voronina, TA | 1 |
Garibova, TL | 1 |
Littrell, RA | 1 |
Sage, T | 1 |
Miller, W | 1 |
Carroll, BT | 1 |
Fruensgaard, K | 1 |
Rebori, A | 1 |
Chiang, N | 1 |
Banerjee, U | 2 |
Barkin, RL | 1 |
Stein, ZL | 1 |
Norton, PR | 1 |
Yanaura, S | 1 |
Suzuki, T | 1 |
Tagashira, E | 1 |
Nurimoto, S | 1 |
Goldstein, DB | 1 |
Hill, RM | 1 |
Verniaud, WM | 1 |
Horning, MG | 1 |
McCulley, LB | 1 |
Morgan, NF | 1 |
Kissin, B | 1 |
Gross, MM | 1 |
Berry, JN | 1 |
Leivonen, P | 1 |
Stenij, P | 1 |
Thesleff, CJ | 1 |
Gastager, H | 1 |
Svestka, J | 1 |
Náhunek, K | 1 |
Lorenzetti, OJ | 1 |
Sancilio, LF | 1 |
Smith, DE | 1 |
Wesson, DR | 1 |
Hofman, G | 1 |
Kryspin-Exner, K | 1 |
Andreani, F | 2 |
Valla, S | 2 |
Ideström, CM | 1 |
Holmberg, G | 1 |
Wegner, ME | 1 |
Fink, DW | 1 |
Kane, FJ | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Feasibility and Efficacy of an Internet-delivered Cognitive-behavioral Intervention for Insomnia in a National Cohort of Danish Breast Cancer Survivors[NCT02444026] | 225 participants (Anticipated) | Interventional | 2014-12-31 | Recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
1 review available for meprobamate and Drug Withdrawal Symptoms
Article | Year |
---|---|
Drug use in outpatient treatment.
Topics: Anxiety; Barbiturates; Chlordiazepoxide; Depression; Diazepam; Educational Status; Humans; Meprobama | 1968 |
Trials
1 trial available for meprobamate and Drug Withdrawal Symptoms
Article | Year |
---|---|
Drug therapy in alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C | 1968 |
Other Studies
41 other studies available for meprobamate and Drug Withdrawal Symptoms
Article | Year |
---|---|
Something old, something new: a successful case of meprobamate withdrawal.
Topics: Aged; Anxiety Disorders; Diazepam; Dose-Response Relationship, Drug; Humans; Inpatients; Male; Mepro | 2016 |
Sleep complaints: Whenever possible, avoid the use of sleeping pills.
Topics: Acupuncture Therapy; Adult; Aged; Behavior Therapy; Benzodiazepines; Clinical Trials as Topic; Conge | 2008 |
Carisoprodol withdrawal after internet purchase.
Topics: Carisoprodol; Humans; Internet; Male; Meprobamate; Middle Aged; Muscle Relaxants, Central; Substance | 2010 |
The use of high dosage Deprol in alcoholic and narcotic withdrawal.
Topics: Alcoholism; Benactyzine; Humans; Meprobamate; Narcotics; Substance Withdrawal Syndrome; Substance-Re | 1962 |
TREATMENT OF MEPROBAMATE WITHDRAWAL SYNDROME.
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Meprobamate; Neurologic Manifestations; Substance Withdraw | 1964 |
AMBULATORY WITHDRAWAL TREATMENT OF HEROIN ADDICTS.
Topics: Chloral Hydrate; Chlorpromazine; Drug Therapy; Glutethimide; Heroin; Humans; Meprobamate; Methylphen | 1964 |
[CEREBRAL ELECTRICAL ANOMALIES ACCOMPANYING THE ONSET OR CESSATION OF NEUROLEPTIC TREATMENTS].
Topics: Antipsychotic Agents; Barbiturates; Electroencephalography; Humans; Meprobamate; Metabolism; Schizop | 1964 |
WITHDRAWAL CONVULSIONS: EPILEPTIC OR NOT?
Topics: Epilepsy; Humans; Meprobamate; Seizures; Substance Withdrawal Syndrome; Toxicology | 1964 |
MEPROBAMATE WITHDRAWAL SYNDROME.
Topics: Humans; Meprobamate; Substance Withdrawal Syndrome; Substance-Related Disorders | 1965 |
CONVULSIONS IN A PILOT FOLLOWING DRUG WITHDRAWAL.
Topics: Aerospace Medicine; Diazepam; Drug Therapy; Meprobamate; Pentobarbital; Psychoses, Substance-Induced | 1965 |
Withdrawal reactions from meprobamate, alone and combined with promazine: a controlled study.
Topics: Behavior, Addictive; Meprobamate; Promazine; Research Design; Substance Withdrawal Syndrome; Substan | 1960 |
Is the frequency of carisoprodol withdrawal syndrome increasing?
Topics: Adult; Anxiety; Carisoprodol; Female; Hallucinations; Humans; Meprobamate; Muscle Relaxants, Central | 2007 |
Diagnosis and management of depressant drug dependence.
Topics: Adult; Aged; Analgesics; Barbiturates; Chlordiazepoxide; Drug Tolerance; Female; Humans; Hypnotics a | 1967 |
The use of clonidine in meprobamate withdrawal.
Topics: Clonidine; Female; Humans; Meprobamate; Middle Aged; Substance Withdrawal Syndrome | 1984 |
Physical dependence on meprobamate after repeated oral administration in rats.
Topics: Administration, Oral; Animals; Body Temperature; Body Weight; Codeine; Humans; Male; Meprobamate; Ph | 1983 |
[Experimental study of the "'rebound syndrome" following discontinuation of prolonged phenazepam administration and possibilities for preventing it].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlorpromazine; Conditioning, Clas | 1981 |
Meprobamate dependence secondary to carisoprodol (Soma) use.
Topics: Adult; Biotransformation; Carisoprodol; Female; Humans; Meprobamate; Metabolic Clearance Rate; Neuro | 1993 |
Catatonia due to mixed sedative withdrawal.
Topics: Adult; Catatonia; Depressive Disorder; Female; Humans; Lorazepam; Meprobamate; Substance Withdrawal | 1997 |
Withdrawal psychosis: a study of 30 consecutive cases.
Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Barbiturates; Benzodiazepines; Codeine; Female; Human | 1976 |
[Withdrawal of meprobamate and reduction of barbiturates in psychiatric patients (author's transl)].
Topics: Humans; Meprobamate; Phenobarbital; Substance Withdrawal Syndrome | 1978 |
Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.
Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Conditioning, Operant; Dose-Response Relation | 1975 |
Withdrawal symptoms in a postoperative patient.
Topics: Aged; Aorta, Abdominal; Aortic Aneurysm; Clonidine; Humans; Hypertension; Intubation, Gastrointestin | 1992 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydr | 1970 |
[Drug dependence in rats: substitution test and sequential changes in body weight].
Topics: Animals; Body Weight; Codeine; Drug Therapy, Combination; Humans; Male; Meprobamate; Morphine; Morph | 1974 |
Programmed self-administration of potentially addictive drugs in young rats and its effects on learning.
Topics: Amphetamine; Animals; Avoidance Learning; Behavior, Animal; Drug Tolerance; Ethanol; Extinction, Psy | 1974 |
A simple method for evaluating physical dependence liability in rats.
Topics: Aminopyrine; Animals; Azepines; Body Weight; Codeine; Cyproheptadine; Dextropropoxyphene; Humans; Ma | 1973 |
An animal model for testing effects of drugs on alcohol withdrawal reactions.
Topics: Animals; Ataxia; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Ethanol; Humans; Male; M | 1972 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Epilepsy precipitated by abrupt meprobamate withdrawal.
Topics: Adult; Epilepsy, Tonic-Clonic; Female; Humans; Meprobamate; Substance Withdrawal Syndrome | 1966 |
Experience with three drugs in ambulatory treatment of alcohol patients.
Topics: Alcoholism; Ambulatory Care; Chlormethiazole; Finland; Humans; Hypnotics and Sedatives; Meprobamate; | 1966 |
Chlormethiazole treatment of abstinence symptoms after drug withdrawal. Preliminary reports. 3.
Topics: Alcoholism; Barbiturates; Chlormethiazole; Humans; Hypnotics and Sedatives; Male; Meprobamate; Subst | 1966 |
[A case of glutethimide and meprobamate dependance with delirium as a drug withdrawal symptom].
Topics: Aged; Delirium; Female; Glutethimide; Humans; Meprobamate; Substance Withdrawal Syndrome; Substance- | 1970 |
Morphine dependent rats as a model for evaluating potential addiction liability of analgesic compounds.
Topics: Analgesics; Animals; Apomorphine; Azepines; Behavior, Animal; Codeine; Dextropropoxyphene; Diphenhyd | 1970 |
A new method for treatment of barbiturate dependence.
Topics: Barbiturates; Chlordiazepoxide; Diazepam; Heroin; Humans; Meprobamate; Pentobarbital; Phenobarbital; | 1970 |
[Drug dependence and addiction among patients of the Vienna Psychiatric-Neurological University Hospital with special reference to psychotropic drugs].
Topics: Analgesics; Antidepressive Agents; Antitussive Agents; Austria; Barbiturates; Cannabis; Chlordiazepo | 1970 |
[On a syndrome due to withdrawl from meprobamates].
Topics: Adult; Hallucinations; Humans; Male; Meprobamate; Seizures; Substance Withdrawal Syndrome; Substance | 1968 |
[On a syndrome due to withdrawal from meprobamates].
Topics: Adult; Hallucinations; Humans; Male; Meprobamate; Seizures; Substance Withdrawal Syndrome; Substance | 1968 |
[Therapy of anxiety, mental anguish and sleeplessness. 4. Drug abuse and accidents].
Topics: Accidents, Traffic; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Drug Synergism; Ethan | 1969 |
[Therapy of anxiety, mental anguish and sleeplessness. 5. Abuse of diazepam?].
Topics: Chlordiazepoxide; Diazepam; Humans; Meprobamate; Substance Withdrawal Syndrome; Substance-Related Di | 1969 |
Chlordiazepoxide (librium) compared with meprobamate and promazine (prozine) for the withdrawal symptoms of acute alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Humans; Male; Meprobamate; Promazine; Substanc | 1965 |
Significance of seizures in patients receiving psychotropic drugs.
Topics: Adult; Drug Hypersensitivity; Epilepsy; Humans; Male; Meprobamate; Phenytoin; Schizophrenia; Seizure | 1965 |