mepivacaine has been researched along with Seizures in 28 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine." | 7.68 | Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990) |
| " Fatal cardiac arrhythmias occurred in, respectively, 3 of 11, 2 of 12, and 2 of 13 conscious sheep infused with bupivacaine, levobupivacaine, and ropivacaine; in 1 of 9 with prilocaine, electromechanical dissociation (followed by polymorphic ventricular tachycardia) caused death." | 3.74 | The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics. ( Copeland, SE; Gu, XQ; Ladd, LA; Mather, LE, 2008) |
| " In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine." | 3.68 | Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990) |
| "Diazepam, oxazepam, N-methyloxazepam, nitrazepam and N-desmethyldiazepam prevented seizures in mice produced by lidocaine, mepivacaine, and prilocaine, and in rats by lidocaine when administered IP five minutes before IP local anesthetic." | 3.66 | Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics. ( Coffman, WB; McFarland, SA; Meyer, EA; Mumford, R; Wynn, RL, 1980) |
| "5 mL/kg/day, the maximum daily dosage recommended by the U." | 1.46 | Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity. ( Banwell, BL; Corwin, DJ; Osterhoudt, K; Topjian, A, 2017) |
| "The patient experienced seizures and dysrhythmias twenty minutes after block completion and injection of the anesthetic solution [Ropivacaine 0." | 1.31 | Acute toxicity of local anesthetic ropivacaine and mepivacaine during a combined lumbar plexus and sciatic block for hip surgery. ( Auffray, JP; Gaillat, F; Lavand'homme, P; Mullanu, Ch; Scemama, F; Thibault, S, 2002) |
| "The convulsions were successfully treated with thiopentone and sevoflurane, there were no neurological sequelae." | 1.29 | Convulsions associated with epidural analgesia during sevoflurane anaesthesia. ( Hirabayashi, Y; Mitsuhata, H; Saitoh, K; Shimizu, R; Tsukamoto, N, 1996) |
| "The comparative pharmacokinetic properties of lidocaine, bupivacaine, etidocaine and mepivacaine were investigated in convulsing and non-convulsing dogs." | 1.27 | Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions. ( Arthur, GR; Covino, BG; Feldman, HS, 1988) |
| "All six survivors are seizure free and neurologically and developmentally normal at one to 4 1/2 years." | 1.26 | Diagnosis, treatment, and follow-up of neonatal mepivacaine intoxication secondary to paracervical and pudendal blocks during labor. ( Dodson, WE; Hillman, LS; Hillman, RE, 1979) |
| "The patient died due to cardiac arrest." | 1.25 | [Accident during local anesthesia in a patient with antiarrhythmic therapy]. ( Breithardt, G; Lautenschläger, J; Schulte, HD; Seipel, L, 1975) |
| "The conclusion of this study was that a respiratory acidosis increased the central nervous system toxicity of local anaesthetics and that the underlying metabolic conditions modified this increase." | 1.25 | Central nervous system effects of local anaesthetic agents. ( Englesson, S; Matousek, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (71.43) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 3 (10.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Obniska, J | 1 |
| Rapacz, A | 1 |
| Rybka, S | 1 |
| Góra, M | 1 |
| Kamiński, K | 1 |
| Sałat, K | 1 |
| Żmudzki, P | 1 |
| Corwin, DJ | 1 |
| Topjian, A | 1 |
| Banwell, BL | 1 |
| Osterhoudt, K | 1 |
| Chon, JY | 1 |
| Hahn, YJ | 1 |
| Sung, CH | 1 |
| Moon, HS | 1 |
| Mullanu, Ch | 1 |
| Gaillat, F | 1 |
| Scemama, F | 1 |
| Thibault, S | 1 |
| Lavand'homme, P | 1 |
| Auffray, JP | 1 |
| YERASIMIDES, TG | 2 |
| MARGOLIS, G | 2 |
| PONTON, HJ | 1 |
| FINSTER, M | 2 |
| POPPERS, PJ | 1 |
| SINCLAIR, JC | 1 |
| MORISHIMA, HO | 2 |
| DANIEL, SS | 1 |
| Copeland, SE | 1 |
| Ladd, LA | 1 |
| Gu, XQ | 1 |
| Mather, LE | 1 |
| Wynn, RL | 1 |
| McFarland, SA | 1 |
| Meyer, EA | 1 |
| Coffman, WB | 1 |
| Mumford, R | 1 |
| Saitoh, K | 1 |
| Tsukamoto, N | 1 |
| Mitsuhata, H | 1 |
| Hirabayashi, Y | 1 |
| Shimizu, R | 1 |
| Breithardt, G | 1 |
| Seipel, L | 1 |
| Schulte, HD | 1 |
| Lautenschläger, J | 1 |
| Englesson, S | 1 |
| Matousek, M | 1 |
| Hillman, LS | 1 |
| Hillman, RE | 1 |
| Dodson, WE | 1 |
| Guillozet, N | 1 |
| Bruguerolle, B | 1 |
| Emperaire, N | 1 |
| Arthur, GR | 2 |
| Covino, BG | 2 |
| Feldman, HS | 1 |
| Dhunér, KG | 2 |
| Löfström, B | 2 |
| Munson, ES | 1 |
| Wagman, IH | 1 |
| Jorfeldt, L | 1 |
| Pernow, B | 1 |
| Persson, B | 1 |
| Wahren, J | 1 |
| Widman, B | 1 |
| Klaschka, F | 1 |
| Rosenberg, FJ | 1 |
| Cooke, WJ | 1 |
| Wessinger, GD | 1 |
| Zsigmond, EK | 1 |
| Havers, L | 1 |
| Dobbs, EC | 1 |
| Ross, NM | 1 |
| Evans, JA | 1 |
| Chastain, GM | 1 |
| Phillips, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficiency of Intravenous Lidocaine to Reduce Coughing and the Hemodynamic Changes Associated to Tracheal Extubation[NCT03731429] | Phase 4 | 144 participants (Anticipated) | Interventional | 2019-04-05 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mepivacaine and Seizures
| Article | Year |
|---|---|
Aspects of the pharmacology of local anaesthetic agents.
Topics: Anesthesia, Obstetrical; Anesthetics, Local; Anilides; Blood Pressure; Central Nervous System; Epine | 1970 |
27 other studies available for mepivacaine and Seizures
| Article | Year |
|---|---|
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electros | 2016 |
Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity.
Topics: Anesthetics, Local; Antidotes; Child; Drug Overdose; Fat Emulsions, Intravenous; Female; Humans; Mep | 2017 |
Amnesia and pain relief after cardiopulmonary resuscitation in a cancer pain patient: a case report.
Topics: Amnesia; Anesthesia, Local; Bone Neoplasms; Breast Neoplasms; Cardiopulmonary Resuscitation; Electro | 2012 |
Acute toxicity of local anesthetic ropivacaine and mepivacaine during a combined lumbar plexus and sciatic block for hip surgery.
Topics: Aged; Aged, 80 and over; Amides; Anesthetics, Local; Arrhythmias, Cardiac; Female; Femoral Neck Frac | 2002 |
PROPHYLAXIS OF EXPERIMENTAL CONTRAST MEDIUM INJURY TO THE SPINAL CORD BY VASODEPRESSOR DRUGS.
Topics: Acetrizoic Acid; Angiography; Blood Circulation; Blood Pressure; Blood Pressure Determination; Contr | 1963 |
ACCIDENTAL INTOXICATION OF THE FETUS WITH LOCAL ANESTHETIC DRUG DURING CAUDAL ANESTHESIA.
Topics: Anesthesia; Anesthesia, Caudal; Anesthesia, Local; Anesthesia, Obstetrical; Anesthesia, Spinal; Anes | 1965 |
The effects of general anesthesia on the central nervous and cardiovascular system toxicity of local anesthetics.
Topics: Acid-Base Equilibrium; Amides; Anesthetics, Inhalation; Anesthetics, Local; Animals; Arrhythmias, Ca | 2008 |
Structure activity relationships of selected benzodiazepines as anticonvulsants to local anesthetics.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Lidocaine; Male; Mepivacain | 1980 |
Convulsions associated with epidural analgesia during sevoflurane anaesthesia.
Topics: Analgesia, Epidural; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Child, Presch | 1996 |
[Accident during local anesthesia in a patient with antiarrhythmic therapy].
Topics: Adolescent; Anesthesia, Local; Aprindine; Cardiac Complexes, Premature; Cardiomyopathies; Drug Inter | 1975 |
Central nervous system effects of local anaesthetic agents.
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Allyl Compounds; Amines; Anesthetics, Local; Anilides; | 1975 |
Diagnosis, treatment, and follow-up of neonatal mepivacaine intoxication secondary to paracervical and pudendal blocks during labor.
Topics: Adult; Anesthesia, Local; Anesthesia, Obstetrical; Female; Follow-Up Studies; Humans; Infant, Newbor | 1979 |
The risks of paracervical anesthesia: intoxication and neurological injury of the newborn.
Topics: Adult; Anesthesia, Obstetrical; Ataxia; Cervix Uteri; Child, Preschool; Exchange Transfusion, Whole | 1975 |
Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
Topics: Anesthesia, Local; Animals; Drug Overdose; Etidocaine; Flumazenil; Lidocaine; Male; Mepivacaine; Mic | 1992 |
Pregnancy does not alter lidocaine toxicity.
Topics: Animals; Blood Pressure; Bupivacaine; Female; Heart Rate; Hypotension; Lidocaine; Mepivacaine; Pregn | 1990 |
Alterations in the pharmacokinetic properties of amide local anaesthetics following local anaesthetic induced convulsions.
Topics: Anesthetics, Local; Animals; Bupivacaine; Dogs; Etidocaine; Lidocaine; Male; Mepivacaine; Seizures | 1988 |
Frequency of general side reactions after regional anaesthesia with mepivacaine with and without vasoconstrictors.
Topics: Adolescent; Adult; Aged; Anesthesia, Conduction; Anesthesia, Local; Anesthesia, Spinal; Autonomic Ne | 1972 |
Studies on the frequency of and reasons for side reactions after regional anaesthesia with mepivacaine with and without vasoconstrictors.
Topics: Adult; Anesthesia, Local; Animals; Blood Circulation; Blood Pressure; Capillary Resistance; Dogs; Ep | 1972 |
Diazepam treatment of local anesthetic-induced seizures.
Topics: Anesthetics, Local; Animals; Blood Gas Analysis; Bupivacaine; Diazepam; Dose-Response Relationship, | 1972 |
The effect of local anaesthetics on the central circulation and respiration in man and dog.
Topics: Anesthetics, Local; Animals; Blood Circulation; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs | 1968 |
[On the frequency of cosmetic complications].
Topics: Accidents, Occupational; Adolescent; Adult; Cosmetics; Drug Hypersensitivity; Female; Humans; Male; | 1968 |
The effect of central nervous system depressants on the tolerance to local anesthetic solutions.
Topics: Anesthetics, Local; Animals; Barbiturates; Chlorpromazine; Drug Synergism; Lidocaine; Male; Meperidi | 1971 |
Convulsions following surgery.
Topics: Adult; Anemia, Sickle Cell; Anesthesia, Local; Female; Humans; Mepivacaine; Seizures; Time Factors | 1971 |
[203. The dangers of local anesthesia].
Topics: Adult; Anesthetics, Local; Epinephrine; Female; Heart Arrest; Humans; Infant; Lidocaine; Male; Mepiv | 1967 |
Convulsive properties of the anilide-derived local anesthetic drugs.
Topics: Animals; Epinephrine; Lidocaine; Mepivacaine; Prilocaine; Rats; Seizures | 1968 |
The use of local anesthetic agents in obstetrics.
Topics: Adult; Anesthesia, Local; Anesthesia, Obstetrical; Anesthetics, Local; Delivery, Obstetric; Female; | 1969 |
Vasopressor potentiation of neurotoxicity in experimental aortography. Implications regarding pathogenesis of contrast medium injury.
Topics: Animals; Aortography; Contrast Media; Dogs; Mepivacaine; Norepinephrine; Paralysis; Seizures; Spinal | 1966 |