Page last updated: 2024-10-30

mepivacaine and Pulpitis

mepivacaine has been researched along with Pulpitis in 12 studies

Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.

Pulpitis: Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to assess inferior alveolar nerve block (IANB) success of 2% mepivacaine (Scandonest 2%, Septodont, France) and 4% articaine (Septanest 4%, Septodont) in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars during access cavity preparation and instrumentation."9.51Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine in patients with symptomatic irreversible pulpitis in mandibular molars: A randomized double-blind single-centre clinical trial. ( Amin, SAW; Bedier, MM; El Boghdadi, RM; Ezzat, K; Fouda, MY; Gawdat, SI; Habib, MFOM; Marzouk, A; Tarek, S; Teama, SME, 2022)
"Aims To compare the anaesthetic efficacy of articaine, lidocaine and mepivacaine for buccal infiltration (BI) following lidocaine inferior alveolar nerve block (IANB) in mandibular posterior teeth with irreversible pulpitis."9.34Comparison of articaine, lidocaine and mepivacaine for buccal infiltration after inferior alveolar nerve block in mandibular posterior teeth with irreversible pulpitis. ( Gao, X; Meng, K, 2020)
"To compare the success of an inferior alveolar nerve block (IANB) after injecting a combination of mepivacaine and tramadol or mepivacaine alone in patients with symptomatic irreversible pulpitis (SIP) in mandibular permanent molars."9.22Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. ( Chavarría-Bolaños, D; Pozos-Guillen, A; Rodríguez-Wong, L; Silva-Herzog, D, 2016)
"The objective of this study was to compare the anesthetic efficacy of 2% mepivacaine combined with 1:100,000 epinephrine with 2% lidocaine combined with 1:100,000 epinephrine during pulpectomy of mandibular posterior teeth in patients with irreversible pulpitis."9.22Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial. ( Buscariolo, IA; Tortamano, IP; Visconti, RP, 2016)
"This study aimed to compare the effectiveness of mepivacaine and lidocaine for pulpal anaesthesia and pain control when administered via an inferior alveolar nerve block during the root canal treatment of mandibular molars in patients with symptomatic irreversible pulpitis."8.98Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis. ( Cericato, GO; Franco, A; Paranhos, LR; Ribeiro, MAG; Vieira, WA, 2018)
"To determine the efficacy of a supplemental intraosseous injection of 3% mepivacaine in mandibular posterior teeth with irreversible pulpitis."7.69Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis. ( Beck, M; Nist, R; Reader, A; Reisman, D; Weaver, J, 1997)
"The aim of this study was to assess inferior alveolar nerve block (IANB) success of 2% mepivacaine (Scandonest 2%, Septodont, France) and 4% articaine (Septanest 4%, Septodont) in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars during access cavity preparation and instrumentation."5.51Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine in patients with symptomatic irreversible pulpitis in mandibular molars: A randomized double-blind single-centre clinical trial. ( Amin, SAW; Bedier, MM; El Boghdadi, RM; Ezzat, K; Fouda, MY; Gawdat, SI; Habib, MFOM; Marzouk, A; Tarek, S; Teama, SME, 2022)
" Five RCTs suggest that both benzocaine 10% and 20% may increase the number of people experiencing pain reduction compared with placebo when managing acute irreversible pulpitis (low certainty)."5.41Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews. ( Azab, M; Brignardello-Petersen, R; Carrasco-Labra, A; Diaz Martinez, JP; He, L; Hersh, EV; Ibrahim, S; Miroshnychenko, A; Moore, PA; Polk, DE; Roldan, Y; Tamilselvan, D; Tampi, M; Urquhart, O, 2023)
"Aims To compare the anaesthetic efficacy of articaine, lidocaine and mepivacaine for buccal infiltration (BI) following lidocaine inferior alveolar nerve block (IANB) in mandibular posterior teeth with irreversible pulpitis."5.34Comparison of articaine, lidocaine and mepivacaine for buccal infiltration after inferior alveolar nerve block in mandibular posterior teeth with irreversible pulpitis. ( Gao, X; Meng, K, 2020)
"To compare the success of an inferior alveolar nerve block (IANB) after injecting a combination of mepivacaine and tramadol or mepivacaine alone in patients with symptomatic irreversible pulpitis (SIP) in mandibular permanent molars."5.22Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. ( Chavarría-Bolaños, D; Pozos-Guillen, A; Rodríguez-Wong, L; Silva-Herzog, D, 2016)
"The objective of this study was to compare the anesthetic efficacy of 2% mepivacaine combined with 1:100,000 epinephrine with 2% lidocaine combined with 1:100,000 epinephrine during pulpectomy of mandibular posterior teeth in patients with irreversible pulpitis."5.22Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial. ( Buscariolo, IA; Tortamano, IP; Visconti, RP, 2016)
"This study aimed to compare the effectiveness of mepivacaine and lidocaine for pulpal anaesthesia and pain control when administered via an inferior alveolar nerve block during the root canal treatment of mandibular molars in patients with symptomatic irreversible pulpitis."4.98Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis. ( Cericato, GO; Franco, A; Paranhos, LR; Ribeiro, MAG; Vieira, WA, 2018)
"To determine the efficacy of a supplemental intraosseous injection of 3% mepivacaine in mandibular posterior teeth with irreversible pulpitis."3.69Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis. ( Beck, M; Nist, R; Reader, A; Reisman, D; Weaver, J, 1997)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (25.00)18.2507
2000's2 (16.67)29.6817
2010's4 (33.33)24.3611
2020's3 (25.00)2.80

Authors

AuthorsStudies
Habib, MFOM1
Tarek, S1
Teama, SME1
Ezzat, K1
El Boghdadi, RM1
Marzouk, A1
Fouda, MY1
Gawdat, SI1
Bedier, MM1
Amin, SAW1
Miroshnychenko, A1
Ibrahim, S1
Azab, M1
Roldan, Y1
Diaz Martinez, JP1
Tamilselvan, D1
He, L1
Urquhart, O1
Tampi, M1
Polk, DE1
Moore, PA1
Hersh, EV1
Carrasco-Labra, A1
Brignardello-Petersen, R2
Gao, X1
Meng, K1
Vieira, WA1
Paranhos, LR1
Cericato, GO1
Franco, A1
Ribeiro, MAG1
Rodríguez-Wong, L1
Pozos-Guillen, A1
Silva-Herzog, D1
Chavarría-Bolaños, D1
Visconti, RP1
Tortamano, IP1
Buscariolo, IA1
Maniglia-Ferreira, C1
Almeida-Gomes, F1
Carvalho-Sousa, B1
Barbosa, AV1
Lins, CC1
Souza, FD1
Santos, RA1
Elsharrawy, EA1
Elbaghdady, YM1
Cohen, HP1
Cha, BY1
Spångberg, LS1
Penniston, SG1
Hargreaves, KM1
Reisman, D1
Reader, A1
Nist, R1
Beck, M1
Weaver, J1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Efficiency of Intraligamentary + Buccal Infiltration Anesthesia and Inferior Alveolar Nerve Block + Buccal Infiltration Anesthesia in Symptomatic Mandibular Molars With Irreversible Pulpitis[NCT05839093]210 participants (Actual)Interventional2021-12-21Completed
Effect of Preoperative Acetaminophen-Codeine-Caffeine Combination on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis: Randomized Double-blind Controlled Trial[NCT04202406]69 participants (Actual)Interventional2021-01-09Completed
Efficacy of the Combination Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial.[NCT02110966]Phase 456 participants (Actual)Interventional2014-04-30Completed
A Prospective, Randomized, Double-blind Study of the Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Inferior Alveolar Nerve Blocks.[NCT01574807]Phase 4100 participants (Actual)Interventional2012-05-31Completed
Comparison of the Efficacy of Prophylactic Intraligamentary Injection of Piroxicam Versus Mepecaine for Management of Post-endodontic Pain in Posterior Teeth[NCT03006107]26 participants (Anticipated)Interventional2016-12-31Not yet recruiting
Comparative Evaluation of Preoperative Methylprednisolone or Ibuprofen on Anesthetic Efficacy of Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis[NCT04157036]Phase 33 participants (Actual)Interventional2020-02-01Terminated (stopped due to COVID halted recruitment for 2 years. A majority of patients eligible for the study had already taken preoperative analgesics, which disqualified them for the study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants Achieving Pulpal Anesthesia Success.

An electric pulp tester will be used to test the lower jaw teeth (molars, premolars, and incisors) for anesthesia (numbness) in 4-minute time cycles for 60 minutes. Measurements of less than 80 on the EPT is considered not numb (anesthesia failure). Readings of 80 equate to anesthetic success. (NCT01574807)
Timeframe: 60 minutes per injection sequence.

InterventionParticipants (Count of Participants)
Mepivacaine + Lidocaine44
Lidocaine + Lidocaine40

Reviews

2 reviews available for mepivacaine and Pulpitis

ArticleYear
Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews.
    Journal of the American Dental Association (1939), 2023, Volume: 154, Issue:1

    Topics: Acute Pain; Anesthesia, Local; Anesthetics, Local; Benzocaine; Bupivacaine; Epinephrine; Humans; Lid

2023
Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis.
    International endodontic journal, 2018, Volume: 51, Issue:10

    Topics: Anesthesia, Dental; Anesthetics, Local; Humans; Lidocaine; Mepivacaine; Nerve Block; Pain Management

2018

Trials

8 trials available for mepivacaine and Pulpitis

ArticleYear
Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine in patients with symptomatic irreversible pulpitis in mandibular molars: A randomized double-blind single-centre clinical trial.
    International endodontic journal, 2022, Volume: 55, Issue:11

    Topics: Anesthetics, Local; Carticaine; Double-Blind Method; Humans; Lidocaine; Mandibular Nerve; Mepivacain

2022
Comparison of articaine, lidocaine and mepivacaine for buccal infiltration after inferior alveolar nerve block in mandibular posterior teeth with irreversible pulpitis.
    British dental journal, 2020, Volume: 228, Issue:8

    Topics: Anesthesia, Dental; Anesthetics, Local; Carticaine; Double-Blind Method; Humans; Lidocaine; Mandibul

2020
Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial.
    International endodontic journal, 2016, Volume: 49, Issue:4

    Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; Human

2016
Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial.
    Journal of endodontics, 2016, Volume: 42, Issue:9

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; Male;

2016
Clinical evaluation of the use of three anesthetics in endodontics.
    Acta odontologica latinoamericana : AOL, 2009, Volume: 22, Issue:1

    Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Cost-Benefit Analysis; Dose-Response Relationship, Dr

2009
A double-blind comparison of a supplemental interligamentary injection of fentanyl and mepivacaine with 1:200,000 epinephrine for irreversible pulpitis.
    Journal of pain and symptom management, 2007, Volume: 33, Issue:2

    Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Double-Blind Method; Drug Therapy, Combination; Epine

2007
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Endodontic anesthesia in mandibular molars: a clinical study.
    Journal of endodontics, 1993, Volume: 19, Issue:7

    Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental

1993
Evaluation of periapical injection of Ketorolac for management of endodontic pain.
    Journal of endodontics, 1996, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Anti-In

1996

Other Studies

2 other studies available for mepivacaine and Pulpitis

ArticleYear
2% mepivacaine seems to do better than 2% lidocaine in achieving successful anesthesia in posterior teeth with irreversible pulpitis.
    Journal of the American Dental Association (1939), 2017, Volume: 148, Issue:4

    Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Humans; Lidocaine; M

2017
Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1997, Volume: 84, Issue:6

    Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bicuspid; Dental Pulp;

1997