mepivacaine has been researched along with Pulpitis in 12 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Pulpitis: Inflammation of the DENTAL PULP, usually due to bacterial infection in dental caries, tooth fracture, or other conditions causing exposure of the pulp to bacterial invasion. Chemical irritants, thermal factors, hyperemic changes, and other factors may also cause pulpitis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to assess inferior alveolar nerve block (IANB) success of 2% mepivacaine (Scandonest 2%, Septodont, France) and 4% articaine (Septanest 4%, Septodont) in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars during access cavity preparation and instrumentation." | 9.51 | Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine in patients with symptomatic irreversible pulpitis in mandibular molars: A randomized double-blind single-centre clinical trial. ( Amin, SAW; Bedier, MM; El Boghdadi, RM; Ezzat, K; Fouda, MY; Gawdat, SI; Habib, MFOM; Marzouk, A; Tarek, S; Teama, SME, 2022) |
| "Aims To compare the anaesthetic efficacy of articaine, lidocaine and mepivacaine for buccal infiltration (BI) following lidocaine inferior alveolar nerve block (IANB) in mandibular posterior teeth with irreversible pulpitis." | 9.34 | Comparison of articaine, lidocaine and mepivacaine for buccal infiltration after inferior alveolar nerve block in mandibular posterior teeth with irreversible pulpitis. ( Gao, X; Meng, K, 2020) |
| "To compare the success of an inferior alveolar nerve block (IANB) after injecting a combination of mepivacaine and tramadol or mepivacaine alone in patients with symptomatic irreversible pulpitis (SIP) in mandibular permanent molars." | 9.22 | Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. ( Chavarría-Bolaños, D; Pozos-Guillen, A; Rodríguez-Wong, L; Silva-Herzog, D, 2016) |
| "The objective of this study was to compare the anesthetic efficacy of 2% mepivacaine combined with 1:100,000 epinephrine with 2% lidocaine combined with 1:100,000 epinephrine during pulpectomy of mandibular posterior teeth in patients with irreversible pulpitis." | 9.22 | Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial. ( Buscariolo, IA; Tortamano, IP; Visconti, RP, 2016) |
| "This study aimed to compare the effectiveness of mepivacaine and lidocaine for pulpal anaesthesia and pain control when administered via an inferior alveolar nerve block during the root canal treatment of mandibular molars in patients with symptomatic irreversible pulpitis." | 8.98 | Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis. ( Cericato, GO; Franco, A; Paranhos, LR; Ribeiro, MAG; Vieira, WA, 2018) |
| "To determine the efficacy of a supplemental intraosseous injection of 3% mepivacaine in mandibular posterior teeth with irreversible pulpitis." | 7.69 | Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis. ( Beck, M; Nist, R; Reader, A; Reisman, D; Weaver, J, 1997) |
| "The aim of this study was to assess inferior alveolar nerve block (IANB) success of 2% mepivacaine (Scandonest 2%, Septodont, France) and 4% articaine (Septanest 4%, Septodont) in patients with symptomatic irreversible pulpitis (SIP) in mandibular molars during access cavity preparation and instrumentation." | 5.51 | Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine in patients with symptomatic irreversible pulpitis in mandibular molars: A randomized double-blind single-centre clinical trial. ( Amin, SAW; Bedier, MM; El Boghdadi, RM; Ezzat, K; Fouda, MY; Gawdat, SI; Habib, MFOM; Marzouk, A; Tarek, S; Teama, SME, 2022) |
| " Five RCTs suggest that both benzocaine 10% and 20% may increase the number of people experiencing pain reduction compared with placebo when managing acute irreversible pulpitis (low certainty)." | 5.41 | Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews. ( Azab, M; Brignardello-Petersen, R; Carrasco-Labra, A; Diaz Martinez, JP; He, L; Hersh, EV; Ibrahim, S; Miroshnychenko, A; Moore, PA; Polk, DE; Roldan, Y; Tamilselvan, D; Tampi, M; Urquhart, O, 2023) |
| "Aims To compare the anaesthetic efficacy of articaine, lidocaine and mepivacaine for buccal infiltration (BI) following lidocaine inferior alveolar nerve block (IANB) in mandibular posterior teeth with irreversible pulpitis." | 5.34 | Comparison of articaine, lidocaine and mepivacaine for buccal infiltration after inferior alveolar nerve block in mandibular posterior teeth with irreversible pulpitis. ( Gao, X; Meng, K, 2020) |
| "To compare the success of an inferior alveolar nerve block (IANB) after injecting a combination of mepivacaine and tramadol or mepivacaine alone in patients with symptomatic irreversible pulpitis (SIP) in mandibular permanent molars." | 5.22 | Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. ( Chavarría-Bolaños, D; Pozos-Guillen, A; Rodríguez-Wong, L; Silva-Herzog, D, 2016) |
| "The objective of this study was to compare the anesthetic efficacy of 2% mepivacaine combined with 1:100,000 epinephrine with 2% lidocaine combined with 1:100,000 epinephrine during pulpectomy of mandibular posterior teeth in patients with irreversible pulpitis." | 5.22 | Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial. ( Buscariolo, IA; Tortamano, IP; Visconti, RP, 2016) |
| "This study aimed to compare the effectiveness of mepivacaine and lidocaine for pulpal anaesthesia and pain control when administered via an inferior alveolar nerve block during the root canal treatment of mandibular molars in patients with symptomatic irreversible pulpitis." | 4.98 | Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis. ( Cericato, GO; Franco, A; Paranhos, LR; Ribeiro, MAG; Vieira, WA, 2018) |
| "To determine the efficacy of a supplemental intraosseous injection of 3% mepivacaine in mandibular posterior teeth with irreversible pulpitis." | 3.69 | Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis. ( Beck, M; Nist, R; Reader, A; Reisman, D; Weaver, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Habib, MFOM | 1 |
| Tarek, S | 1 |
| Teama, SME | 1 |
| Ezzat, K | 1 |
| El Boghdadi, RM | 1 |
| Marzouk, A | 1 |
| Fouda, MY | 1 |
| Gawdat, SI | 1 |
| Bedier, MM | 1 |
| Amin, SAW | 1 |
| Miroshnychenko, A | 1 |
| Ibrahim, S | 1 |
| Azab, M | 1 |
| Roldan, Y | 1 |
| Diaz Martinez, JP | 1 |
| Tamilselvan, D | 1 |
| He, L | 1 |
| Urquhart, O | 1 |
| Tampi, M | 1 |
| Polk, DE | 1 |
| Moore, PA | 1 |
| Hersh, EV | 1 |
| Carrasco-Labra, A | 1 |
| Brignardello-Petersen, R | 2 |
| Gao, X | 1 |
| Meng, K | 1 |
| Vieira, WA | 1 |
| Paranhos, LR | 1 |
| Cericato, GO | 1 |
| Franco, A | 1 |
| Ribeiro, MAG | 1 |
| Rodríguez-Wong, L | 1 |
| Pozos-Guillen, A | 1 |
| Silva-Herzog, D | 1 |
| Chavarría-Bolaños, D | 1 |
| Visconti, RP | 1 |
| Tortamano, IP | 1 |
| Buscariolo, IA | 1 |
| Maniglia-Ferreira, C | 1 |
| Almeida-Gomes, F | 1 |
| Carvalho-Sousa, B | 1 |
| Barbosa, AV | 1 |
| Lins, CC | 1 |
| Souza, FD | 1 |
| Santos, RA | 1 |
| Elsharrawy, EA | 1 |
| Elbaghdady, YM | 1 |
| Cohen, HP | 1 |
| Cha, BY | 1 |
| Spångberg, LS | 1 |
| Penniston, SG | 1 |
| Hargreaves, KM | 1 |
| Reisman, D | 1 |
| Reader, A | 1 |
| Nist, R | 1 |
| Beck, M | 1 |
| Weaver, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Efficiency of Intraligamentary + Buccal Infiltration Anesthesia and Inferior Alveolar Nerve Block + Buccal Infiltration Anesthesia in Symptomatic Mandibular Molars With Irreversible Pulpitis[NCT05839093] | 210 participants (Actual) | Interventional | 2021-12-21 | Completed | |||
| Effect of Preoperative Acetaminophen-Codeine-Caffeine Combination on Inferior Alveolar Nerve Block Success in Patients With Symptomatic Irreversible Pulpitis: Randomized Double-blind Controlled Trial[NCT04202406] | 69 participants (Actual) | Interventional | 2021-01-09 | Completed | |||
| Efficacy of the Combination Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: a Randomized Clinical Trial.[NCT02110966] | Phase 4 | 56 participants (Actual) | Interventional | 2014-04-30 | Completed | ||
| A Prospective, Randomized, Double-blind Study of the Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Inferior Alveolar Nerve Blocks.[NCT01574807] | Phase 4 | 100 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| Comparison of the Efficacy of Prophylactic Intraligamentary Injection of Piroxicam Versus Mepecaine for Management of Post-endodontic Pain in Posterior Teeth[NCT03006107] | 26 participants (Anticipated) | Interventional | 2016-12-31 | Not yet recruiting | |||
| Comparative Evaluation of Preoperative Methylprednisolone or Ibuprofen on Anesthetic Efficacy of Inferior Alveolar Nerve Blocks in Patients With Symptomatic Irreversible Pulpitis[NCT04157036] | Phase 3 | 3 participants (Actual) | Interventional | 2020-02-01 | Terminated (stopped due to COVID halted recruitment for 2 years. A majority of patients eligible for the study had already taken preoperative analgesics, which disqualified them for the study.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
An electric pulp tester will be used to test the lower jaw teeth (molars, premolars, and incisors) for anesthesia (numbness) in 4-minute time cycles for 60 minutes. Measurements of less than 80 on the EPT is considered not numb (anesthesia failure). Readings of 80 equate to anesthetic success. (NCT01574807)
Timeframe: 60 minutes per injection sequence.
| Intervention | Participants (Count of Participants) |
|---|---|
| Mepivacaine + Lidocaine | 44 |
| Lidocaine + Lidocaine | 40 |
2 reviews available for mepivacaine and Pulpitis
| Article | Year |
|---|---|
Injectable and topical local anesthetics for acute dental pain: 2 systematic reviews.
Topics: Acute Pain; Anesthesia, Local; Anesthetics, Local; Benzocaine; Bupivacaine; Epinephrine; Humans; Lid | 2023 |
Is mepivacaine as effective as lidocaine during inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis? A systematic review and meta-analysis.
Topics: Anesthesia, Dental; Anesthetics, Local; Humans; Lidocaine; Mepivacaine; Nerve Block; Pain Management | 2018 |
8 trials available for mepivacaine and Pulpitis
| Article | Year |
|---|---|
Inferior alveolar nerve block success of 2% mepivacaine versus 4% articaine in patients with symptomatic irreversible pulpitis in mandibular molars: A randomized double-blind single-centre clinical trial.
Topics: Anesthetics, Local; Carticaine; Double-Blind Method; Humans; Lidocaine; Mandibular Nerve; Mepivacain | 2022 |
Comparison of articaine, lidocaine and mepivacaine for buccal infiltration after inferior alveolar nerve block in mandibular posterior teeth with irreversible pulpitis.
Topics: Anesthesia, Dental; Anesthetics, Local; Carticaine; Double-Blind Method; Humans; Lidocaine; Mandibul | 2020 |
Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; Human | 2016 |
Comparison of the Anesthetic Efficacy of Mepivacaine and Lidocaine in Patients with Irreversible Pulpitis: A Double-blind Randomized Clinical Trial.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Double-Blind Method; Female; Humans; Lidocaine; Male; | 2016 |
Clinical evaluation of the use of three anesthetics in endodontics.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Cost-Benefit Analysis; Dose-Response Relationship, Dr | 2009 |
A double-blind comparison of a supplemental interligamentary injection of fentanyl and mepivacaine with 1:200,000 epinephrine for irreversible pulpitis.
Topics: Adult; Analgesics, Opioid; Anesthetics, Local; Double-Blind Method; Drug Therapy, Combination; Epine | 2007 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Endodontic anesthesia in mandibular molars: a clinical study.
Topics: Anesthesia, Dental; Anesthesia, Local; Chi-Square Distribution; Chlorofluorocarbons, Methane; Dental | 1993 |
Evaluation of periapical injection of Ketorolac for management of endodontic pain.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anesthetics, Local; Anti-In | 1996 |
2 other studies available for mepivacaine and Pulpitis
| Article | Year |
|---|---|
2% mepivacaine seems to do better than 2% lidocaine in achieving successful anesthesia in posterior teeth with irreversible pulpitis.
Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Humans; Lidocaine; M | 2017 |
Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis.
Topics: Adolescent; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bicuspid; Dental Pulp; | 1997 |