mepivacaine has been researched along with Neuroblastoma in 3 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In in vitro studies, the voltage-clamp method was employed to examine whether nisoxetine blocked Na(+) currents in mouse neuroblastoma N2A cells." | 3.79 | Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. ( Chen, YW; Chu, CC; Kuo, CS; Leung, YM; Wang, JJ, 2013) |
| "Lidocaine treatment resulted in suppression of the mitochondrial electron transport chain and subsequent attenuation of mitochondrial membrane potential, as well as enhanced ROS production, activation of caspase-3/7 and caspase-9, and induction of apoptosis and necrosis in SH-SY5Y cells in a dose- and time-dependent manner." | 1.43 | The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells. ( Hirota, K; Kusunoki, M; Matsuo, Y; Nishi, K; Okamoto, A; Oku, K; Shingu, K; Sumi, C; Takenaga, K; Tanaka, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leung, YM | 1 |
| Chu, CC | 1 |
| Kuo, CS | 1 |
| Chen, YW | 1 |
| Wang, JJ | 1 |
| Okamoto, A | 1 |
| Tanaka, M | 1 |
| Sumi, C | 1 |
| Oku, K | 1 |
| Kusunoki, M | 1 |
| Nishi, K | 1 |
| Matsuo, Y | 1 |
| Takenaga, K | 1 |
| Shingu, K | 1 |
| Hirota, K | 1 |
| De la Calle, JL | 1 |
| Paíno, CL | 1 |
3 other studies available for mepivacaine and Neuroblastoma
| Article | Year |
|---|---|
Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; | 2013 |
The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells.
Topics: Acetylcysteine; Anesthetics, Local; Antioxidants; Apoptosis; Bupivacaine; Cell Death; Cell Line, Tum | 2016 |
A procedure for direct lumbar puncture in rats.
Topics: Animals; Cerebrospinal Fluid; Female; Fluorescent Dyes; Humans; Immunohistochemistry; Injections, Sp | 2002 |