mepivacaine has been researched along with Nervous System Diseases in 6 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mepivacaine seems to be a promising alternative to lidocaine for outpatient surgical procedures because of its similar duration of action." | 2.69 | Transient neurologic symptoms after spinal anesthesia with mepivacaine and lidocaine. ( Chisholm, MF; Liguori, GA; Zayas, VM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bang-Vojdanovski, B | 1 |
| Hannibal, H | 1 |
| Eberhardt, M | 1 |
| YaDeau, JT | 1 |
| Liguori, GA | 2 |
| Zayas, VM | 2 |
| Chisholm, MF | 1 |
| Westhues, M | 1 |
| Guillozet, N | 1 |
| Brüel, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Controlled, Double-Blind Trial of 3 Local Anesthetics for Spinal Anesthesia in Primary Total Hip Arthroplasty to Compare the Percentage of Patients in Each Group With Early Ambulation[NCT03948386] | Phase 4 | 159 participants (Actual) | Interventional | 2019-05-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
length of hospital stay (NCT03948386)
Timeframe: hospital stay (0-3 days)
| Intervention | hours (Median) |
|---|---|
| Isobaric Bupivacaine | 26 |
| Hyperbaric Bupivacaine | 26 |
| Isobaric Mepivacaine | 22 |
number of patients with dizziness when transitioning from lying down to sitting or standing (NCT03948386)
Timeframe: Postoperative day 2
| Intervention | Participants (Count of Participants) |
|---|---|
| Isobaric Bupivacaine | 11 |
| Hyperbaric Bupivacaine | 7 |
| Isobaric Mepivacaine | 9 |
Number of patients with TNS events occurring. Transient neurological symptoms were defined as new onset of back, buttock, or thigh pain occurring after spinal anesthesia. (NCT03948386)
Timeframe: Postoperative days 0-2
| Intervention | Participants (Count of Participants) |
|---|---|
| Isobaric Bupivacaine | 2 |
| Hyperbaric Bupivacaine | 6 |
| Isobaric Mepivacaine | 5 |
number of patients with inability to urinate within 8 hours of surgery OR a report of distended or painful bladder occurring on postoperative day 0 or 1, either by patient report or on palpation by nursing (NCT03948386)
Timeframe: postoperative day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Isobaric Bupivacaine | 6 |
| Hyperbaric Bupivacaine | 8 |
| Isobaric Mepivacaine | 5 |
Is there a difference between isobaric mepivacaine, hyperbaric bupivacaine, and isobaric bupivacaine when used for spinal anesthesia in primary total hip replacement in percentage of patients that can ambulate within 3.5 hours after spinal anesthesia? (NCT03948386)
Timeframe: 3.5 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Isobaric Bupivacaine | 9 |
| Hyperbaric Bupivacaine | 20 |
| Isobaric Mepivacaine | 35 |
time to return of motor function of the thigh and lower leg (NCT03948386)
Timeframe: Postoperative day 0 (day of surgery)
| Intervention | minutes (Median) |
|---|---|
| Isobaric Bupivacaine | 148 |
| Hyperbaric Bupivacaine | 123 |
| Isobaric Mepivacaine | 109 |
2 trials available for mepivacaine and Nervous System Diseases
| Article | Year |
|---|---|
The incidence of transient neurologic symptoms after spinal anesthesia with mepivacaine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analysis of Variance; An | 2005 |
Transient neurologic symptoms after spinal anesthesia with mepivacaine and lidocaine.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, Spinal; Arthroscopy; Back Pain; Double-Blind Meth | 1998 |
4 other studies available for mepivacaine and Nervous System Diseases
| Article | Year |
|---|---|
[Transient neurologic symptoms after spinal anesthesia with 4% hyperbaric mepivacaine].
Topics: Adult; Anesthesia, Spinal; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Arthroscopy; | 2002 |
[Local anaesthesia--modern outlook, faults and complications (author's transl)].
Topics: Anesthesia, Local; Bupivacaine; Humans; Lidocaine; Mepivacaine; Nervous System Diseases; Procaine | 1976 |
The risks of paracervical anesthesia: intoxication and neurological injury of the newborn.
Topics: Adult; Anesthesia, Obstetrical; Ataxia; Cervix Uteri; Child, Preschool; Exchange Transfusion, Whole | 1975 |
[Letter: Neurotherapy].
Topics: Angina Pectoris; Humans; Mepivacaine; Nervous System Diseases | 1976 |