Page last updated: 2024-10-30

mepivacaine and Muscle Disorders

mepivacaine has been researched along with Muscle Disorders in 3 studies

Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"In a double-blind study 28 patients with acute, localised muscle pain received four local injections of mepivacaine 0."9.05A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain. ( Frost, FA; Jessen, B; Siggaard-Andersen, J, 1980)
"In a double-blind study 28 patients with acute, localised muscle pain received four local injections of mepivacaine 0."5.05A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain. ( Frost, FA; Jessen, B; Siggaard-Andersen, J, 1980)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jiménez-Díaz, F1
Jimena, I1
Luque, E1
Mendizábal, S1
Bouffard, A1
Jiménez-Reina, L1
Peña, J1
Frost, FA1
Jessen, B1
Siggaard-Andersen, J1
Lucas, M1
Hinojosa, M1
Rodríguez, A1
Garcia-Guasch, R1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Double-blind, Prospective Comparison of Medications Used in Trigger Point Injections - Ketorolac, Lidocaine, or Dexamethasone[NCT03028012]Phase 410 participants (Actual)Interventional2017-05-02Terminated (stopped due to Poor enrollment.)
Trigger Point Injection for Myofascial Pain Syndrome in the Low Back (T-PIMPS): A Randomized Controlled Trial.[NCT04704297]Phase 4180 participants (Anticipated)Interventional2020-12-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With a Responder Rate Greater Than 50% on the Numeric Rating Pain Scale (NRS) Improvement

Participants in this study underwent TPIs by the following method. The needle was inserted into the trigger point with the goal of eliciting a local twitch responses(LTRs). When a LTR was obtained, 0.1mL of randomized drug was injected into that location within the muscle. This was repeated until LTRs disappeared, or 1.0mL had been injected, whichever came first. This was performed in a similar manner for all affected muscles, up to a maximum of 2mL. Participants self-report their brief pain inventory at each of their injections (up to four subsequent injections) based off of the standardized Numeric Rating pain Scale (NRS). The NRS is nationally recognized numeric scale from zero to ten, with zero being an example of no pain, one to three would demonstrate mild pain, four to six would be moderate pain, seven to nine would be severe pain and a ten would be the worst pain possible. Improvement in BPI was determined if their NRS score went down with each injection(s). (NCT03028012)
Timeframe: Pre-Post Injections Up to Three Months

InterventionParticipants (Count of Participants)
Ketorolac1
Lidocaine0
Dexamethasone0

Brief Pain Inventory (BPI) - Modified

The BPI was evaluated on a scale from 0-10. Zero would mean no interference and 10 would be calculated at complete interferences. We used a 7-point questionnaire about pain. All scores were calculated at baseline and three months. (NCT03028012)
Timeframe: Baseline and Three Months

Interventionscore on a scale (Number)
Participant Number #3 at BaselineParticipant Number #3 at 3 MonthsParticipant Number #8 at BaselineParticipant #8 at 3 Months
Ketorolac8353

Numeric Rating Pain Scale (NRS) at Baseline and Three Months.

TPI were treated with a needle inserted into the trigger point with the goal of eliciting a local twitch responses(LTRs). When a LTR was obtained, 0.1mL of randomized drug was injected into that location within the muscle. This was repeated until LTRs disappeared, or 1.0mL had been injected, whichever came first. Such was performed in a similar manner for all affected muscles, up to a maximum of 2mL. Participants self-report their brief pain inventory at each of their injections (up to four subsequent injections) based off of the standardized Numeric Rating pain Scale (NRS). The NRS is nationally recognized numeric scale from zero to ten, with zero being an example of no pain,one to three would demonstrate mild pain, four to six would be moderate pain, seven to nine would be severe pain and a ten would be the worst pain possible. Improvement in BPI was determined if their NRS score went down with each injection(s). (NCT03028012)
Timeframe: Pre-Injection and Three Month Post Injection(s)

Interventionscore on a scale (Number)
Participant Number 3 at BaselineParticipant Number 3 at 3 MonthsParticipant Number 8 at BaselineParticipant Number 8 at 3 Months
Ketorolac8353

Trials

1 trial available for mepivacaine and Muscle Disorders

ArticleYear
A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain.
    Lancet (London, England), 1980, Mar-08, Volume: 1, Issue:8167

    Topics: Clinical Trials as Topic; Double-Blind Method; Fascia; Female; Humans; Injections, Intramuscular; Ma

1980
A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain.
    Lancet (London, England), 1980, Mar-08, Volume: 1, Issue:8167

    Topics: Clinical Trials as Topic; Double-Blind Method; Fascia; Female; Humans; Injections, Intramuscular; Ma

1980
A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain.
    Lancet (London, England), 1980, Mar-08, Volume: 1, Issue:8167

    Topics: Clinical Trials as Topic; Double-Blind Method; Fascia; Female; Humans; Injections, Intramuscular; Ma

1980
A control, double-blind comparison of mepivacaine injection versus saline injection for myofascial pain.
    Lancet (London, England), 1980, Mar-08, Volume: 1, Issue:8167

    Topics: Clinical Trials as Topic; Double-Blind Method; Fascia; Female; Humans; Injections, Intramuscular; Ma

1980

Other Studies

2 other studies available for mepivacaine and Muscle Disorders

ArticleYear
Experimental muscle injury: correlation between ultrasound and histological findings.
    Muscle & nerve, 2012, Volume: 45, Issue:5

    Topics: Anesthetics, Local; Animals; Disease Models, Animal; Male; Mepivacaine; Muscle, Skeletal; Muscular D

2012
Anaesthesia in lipid myopathy.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:7

    Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Local; Carnitine; C

2000