mepivacaine has been researched along with Hypotension in 24 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine." | 7.68 | Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990) |
| "The ephedrine dose required was higher in non-preloaded patients than in preloaded ones (10." | 6.69 | [Preloading with 500 ml of Hartmann's solution lessens the incidence and severity of hypotension and reduces the need for ephedrine after epidural anesthesia in ambulatory patients]. ( Aymerich, H; Cobian-Llamas, JM; Figueira, A; Pensado, A; Rama-Maceiras, P; Rodríguez-Valladares, M, 1999) |
| "5% hyperbaric bupivacaine with sequential epidural block induced by 5-10 ml of 2% mepivacaine caused no hypotension during cesarean section." | 3.72 | [Combined spinal and epidural anesthesia for cesarean section: a retrospective study with 0.5% hyperbaric bupivacaine]. ( Iwasaki, T; Kasaba, T; Maruta, T; Miura, H; Takasaki, M; Tamura, R, 2004) |
| " The development of subdural block was suspected from unexpectedly severe hypotension with small doses of mepivacaine during operation and was confirmed by a characteristic X-ray photograph after operation." | 3.69 | [Diagnosis of accidental subdural block]. ( Fukuda, H; Hirabayashi, Y; Kasuda, H; Mitsuhata, H; Saitoh, K; Shimizu, R, 1995) |
| " In contrast, ovine pregnancy does not enhance the toxicity of mepivacaine, a drug with properties similar to lidocaine." | 3.68 | Pregnancy does not alter lidocaine toxicity. ( Arthur, GR; Covino, BG; Finster, M; Morishima, HO, 1990) |
| "The ephedrine dose required was higher in non-preloaded patients than in preloaded ones (10." | 2.69 | [Preloading with 500 ml of Hartmann's solution lessens the incidence and severity of hypotension and reduces the need for ephedrine after epidural anesthesia in ambulatory patients]. ( Aymerich, H; Cobian-Llamas, JM; Figueira, A; Pensado, A; Rama-Maceiras, P; Rodríguez-Valladares, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (37.50) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Janssen, H | 1 |
| Stosch, Rv | 1 |
| Pöschl, R | 1 |
| Büttner, B | 1 |
| Bauer, M | 1 |
| Hinz, JM | 1 |
| Bergmann, I | 1 |
| Clausel, H | 1 |
| Touffet, L | 1 |
| Havaux, M | 1 |
| Lamard, M | 1 |
| Savean, J | 1 |
| Cochener, B | 1 |
| Arvieux, C | 1 |
| Gueret, G | 1 |
| Meierhenrich, R | 1 |
| Wagner, F | 1 |
| Schütz, W | 1 |
| Rockemann, M | 1 |
| Steffen, P | 1 |
| Senftleben, U | 1 |
| Gauss, A | 1 |
| Kasaba, T | 1 |
| Tamura, R | 1 |
| Iwasaki, T | 1 |
| Maruta, T | 1 |
| Miura, H | 1 |
| Takasaki, M | 1 |
| el-Shirbiny, AM | 1 |
| Rasheed, MH | 1 |
| Elmaghraby, A | 1 |
| Motaweh, M | 1 |
| Hartung, HJ | 1 |
| Osswald, PM | 1 |
| Tolksdorf, W | 1 |
| Bender, HJ | 1 |
| Lutz, H | 1 |
| Saitoh, K | 1 |
| Kasuda, H | 1 |
| Hirabayashi, Y | 1 |
| Fukuda, H | 1 |
| Mitsuhata, H | 1 |
| Shimizu, R | 1 |
| Hahn, RG | 3 |
| Drobin, D | 1 |
| Singelyn, FJ | 1 |
| Gouverneur, JM | 1 |
| Robert, A | 1 |
| Takeda, T | 1 |
| Iida, H | 1 |
| Ohta, S | 1 |
| Oda, A | 1 |
| Abe, K | 1 |
| Oohata, H | 1 |
| Akamatsu, S | 1 |
| Dohi, S | 1 |
| Rama-Maceiras, P | 1 |
| Aymerich, H | 1 |
| Pensado, A | 1 |
| Figueira, A | 1 |
| Rodríguez-Valladares, M | 1 |
| Cobian-Llamas, JM | 1 |
| Akata, T | 1 |
| Murakami, J | 1 |
| Yoshinaga, A | 1 |
| Plaja, I | 1 |
| Arxer, A | 1 |
| Metje, M | 1 |
| Santiveri, X | 1 |
| Villalonga, A | 1 |
| Fernández, MA | 1 |
| López, MA | 1 |
| D'Eramo, EM | 1 |
| Morishima, HO | 1 |
| Finster, M | 1 |
| Arthur, GR | 1 |
| Covino, BG | 1 |
| Nishimura, N | 1 |
| Kajimoto, Y | 1 |
| Kabe, T | 1 |
| Sakamoto, A | 1 |
| Sehhati, G | 1 |
| Frey, R | 1 |
| Mildner, R | 1 |
| Diesbecq, W | 1 |
| Rolly, G | 1 |
| Thiery, M | 1 |
| Shnider, SM | 1 |
| Cohen, CA | 1 |
| Moore, DC | 1 |
| Bridenbaugh, LD | 1 |
| Bridenbaugh, PO | 1 |
| Tucker, GT | 1 |
| Romine, JC | 1 |
| Clark, RB | 1 |
| Brown, WE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia[NCT02148809] | 14 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"An indicator dilution technique was used to measure the blood volume, plasma volume and red cell blood volume. Approved by the Food and Drug Administration in 1998, the BVA-100 blood volume analyzer (Daxor Corp.) is a semi-automated system for blood volume analysis. Prepared standards and injectates were used. The injectate consists of 31I-labeled HSA (370- 1,295 kBq [10-30 mCi]) in saline.~Measurement was performed directly before surgery in the holding area and 6 hours after surgery.~Each time, before injection of the tracer a baseline sample was taken. After injection of the tracer via standard i.v. line, the first sample was drawn from an arterial line after 12 minutes waiting time. Afterwards every 6 minutes a sample was taken. In a whole 5 samples were sent for analysis to Daxor® Corp.. Each sample is counted in duplicate." (NCT02148809)
Timeframe: preoperative and 6 hours postoperatively
| Intervention | ml (Mean) |
|---|---|
| Pilot Study | 214 |
The primary outcome is the change in total blood volume (TBV) during the first 6 hours after primary THA utilizing hypotensive anesthesia. Preoperative TBV will be compared to values 6 hours postoperatively. (NCT02148809)
Timeframe: preoperatively and 6 hours postoperatively
| Intervention | ml (Mean) |
|---|---|
| Pilot Study | 487 |
8 trials available for mepivacaine and Hypotension
| Article | Year |
|---|---|
Blood pressure response to combined general anaesthesia/interscalene brachial plexus block for outpatient shoulder arthroscopy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, General; Ane | 2014 |
[Peribulbar anesthesia: efficacy of a single injection with a limited local anesthetic volume].
Topics: Aged; Amides; Anesthetics, Local; Cataract Extraction; Dose-Response Relationship, Drug; Drug Combin | 2008 |
The effects of thoracic epidural anesthesia on hepatic blood flow in patients under general anesthesia.
Topics: Adjuvants, Anesthesia; Adult; Aged; Analgesia, Epidural; Anesthesia, General; Anesthetics, Local; Bl | 2009 |
Increased haemodilution in hypotension induced by epidural anaesthesia.
Topics: Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthesia, Spinal; Blood Glucose; Blood Pressure; Bl | 1993 |
A minimum dose of clonidine added to mepivacaine prolongs the duration of anesthesia and analgesia after axillary brachial plexus block.
Topics: Adrenergic alpha-Agonists; Adult; Ambulatory Surgical Procedures; Analgesia; Analgesics; Anesthetics | 1996 |
[Preloading with 500 ml of Hartmann's solution lessens the incidence and severity of hypotension and reduces the need for ephedrine after epidural anesthesia in ambulatory patients].
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, Epidural; Anesthetics, Local; Baroreflex; Ephedri | 1999 |
[Comparative study between 5% prilocaine and 2% mepivacaine by the subarachnoid route in transurethral resections].
Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Anesthetics, Local; Autonomic Nerve Block; Bradycardia; | 2000 |
Haemoglobin dilution from epidural-induced hypotension with and without fluid loading.
Topics: Aged; Aged, 80 and over; Anesthesia, Epidural; Epinephrine; Hemoglobins; Humans; Hypotension; Isoton | 1992 |
16 other studies available for mepivacaine and Hypotension
| Article | Year |
|---|---|
[Combined spinal and epidural anesthesia for cesarean section: a retrospective study with 0.5% hyperbaric bupivacaine].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupiva | 2004 |
Experiences with carbocaine in spinal anaesthesia. Report of 20,000 cases.
Topics: Anesthesia, Spinal; Chemical Phenomena; Chemistry; Female; Headache; Humans; Hypotension; Male; Mepi | 1966 |
[Incidence of complications with plexus anaesthesia; a computer-assisted evaluation (author's transl)].
Topics: Anesthesia, Conduction; Arrhythmias, Cardiac; Cervical Plexus; Computers; Humans; Hypertension; Hypo | 1982 |
[Diagnosis of accidental subdural block].
Topics: Anesthesia, Epidural; Central Nervous System Diseases; Diagnosis, Differential; Humans; Hypotension; | 1995 |
Time course of increased haemodilution in hypotension induced by extradural anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Epidural; Anesthetics, Local; Blood Pressure; Fluid Ther | 1996 |
[Two elderly patients with thoracic herpetic pain and post herpetic neuralgia treated with continuous thoracic sympathetic ganglion block through a placed catheter].
Topics: Aged; Analgesia, Epidural; Anesthetics, Local; Autonomic Nerve Block; Catheters, Indwelling; Ganglia | 1998 |
Life-threatening haemorrhage following obturator artery injury during transurethral bladder surgery: a sequel of an unsuccessful obturator nerve block.
Topics: Aged; Anesthetics, Local; Arteries; Blood Loss, Surgical; Electric Stimulation; Electrosurgery; Huma | 1999 |
Morbidity and mortality with outpatient anesthesia: the Massachusetts experience.
Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intraveno | 1992 |
Pregnancy does not alter lidocaine toxicity.
Topics: Animals; Blood Pressure; Bupivacaine; Female; Heart Rate; Hypotension; Lidocaine; Mepivacaine; Pregn | 1990 |
The effects of volume loading during epidural analgesia.
Topics: Adult; Aged; Anesthesia, Epidural; Blood Pressure; Cardiac Output; Colloids; Female; Fluid Therapy; | 1985 |
[Complications of regional anaesthesia and their treatment (author's transl)].
Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis | 1973 |
Continuous lumbar epidural analgesia during labor and delivery.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Back Pain; Bradycardia; Bupivacaine; Female; F | 1974 |
New and interesting aspects of obstetric conduction anesthesia. A. Placental transfer of local anesthetics.
Topics: Anesthesia, Conduction; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Animals; Fe | 1966 |
Anesthetic management of a patient with the Shy-Drager syndrome.
Topics: Anesthesia, Conduction; Anesthesia, Epidural; Anesthetics; Fecal Incontinence; Humans; Hypotension; | 1971 |
Caudal and epidural blocks with bupivacaine for childbirth. Report of 657 parturients.
Topics: Analgesia; Anesthesia, Conduction; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal | 1971 |
Lumbar epidural anaesthesia in labour and delivery: one year's experience.
Topics: Adult; Anesthesia, Obstetrical; Anesthesia, Spinal; Delivery, Obstetric; Extraction, Obstetrical; Fe | 1970 |