mepivacaine has been researched along with Hypersensitivity in 2 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hydrodistension is the first choice of treatment for interstitial cystitis because it allows for diagnosis, bladder biopsy and treatment." | 1.32 | Adjuvant hydrodistension under epidural anesthesia for interstitial cystitis. ( Andoh, M; Murayama, T; Yamada, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamada, T | 1 |
| Murayama, T | 1 |
| Andoh, M | 1 |
| Añíbarro, B | 1 |
| Seoane, FJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Preemptive Pudendal Nerve Block Prior to Hydrodistension for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS): a Prospective, Double-blinded, Randomized Control Trial[NCT02517996] | 18 participants (Actual) | Interventional | 2015-02-28 | Terminated (stopped due to Preliminary results were promising when interim analysis performed but terminated due to primary investigators left recruitment site.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"To determine the change in interstitial cystitis symptom index at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC symptom index questionnaire consists of 4 questions on IC symptoms. 2 of the questions have 6 answer choices ranging from 0-never, to 5-almost always. 1 question has 6 answer choices ranging from 0-never to 5-usually. 1 question has 7 answer choices ranging from 0-never to 6-5 or more times. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 21. A higher score indicates greater severity of IC symptoms." (NCT02517996)
Timeframe: Baseline, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 12.5 | 11.43 | 11.8 | 10 |
| Normal Saline | 10 | 9 | 8.67 | 5 |
"To determine the change in pain at 2 hours, 2 weeks, 6 weeks, and 3 months postoperatively in patients undergoing hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline) using the visual analog scale (VAS).~VAS consists of a 10cm horizontal line with the minimum endpoint labeled no pain (0) and maximum labeled worst pain ever (10). Patients placed a mark on the point that corresponds to the level of pain severity they felt. The cm distance from the low end of the VAS to the patient's mark is used as the numerical index of the intensity of pain. Pain scores of 3.0-5.4 cm are moderate, over 5.4 indicates severe pain." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Pre operative VAS score | Post operative VAS score | 2 week post operative VAS scores | 6 week post operative VAS score | 12 weeks post operative VAS score | |
| 1% Lidocaine | 3.125 | 3.75 | 2.7 | 3 | 2.6 |
| Normal Saline | 4.5 | 5 | 4.8 | 4.33 | 2 |
"To determine the change in pelvic urgency, pain and frequency (PUF) questionnaire at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The Pelvic Urgency, Pain, and Frequency Patient Symptom Scale asks 11 questions, 7 on PUF symptoms, 4 on how bothersome PUF symptoms are. Symptom questions include 3, 4, or 5 ranked answers, with higher answers indicating more voids, or greater frequency of pain. The bother questions each of 4 ranked answers from 0-never, to 3-always. The symptom score is added, the bother score is added, and then the total score is added. The total PUF score is then reported. The minimum score is 0 and the maximum score is 35, and a higher score indicates greater symptoms and higher bother from pelvic pain and frequency." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 22.63 | 18.83 | 18.2 | 17.2 |
| Normal Saline | 19 | 17.4 | 16.7 | 14 |
"To determine the change in problem index (O'Leary Sant) at baseline, 2 hours, 2 weeks, 6 weeks and 3 months after hydrodistention with preemptive pudendal nerve block (1% Lidocaine) compared to hydrodistention with placebo (saline).~The IC problem index questionnaire consists of 4 questions on how much of a problem a patient's IC symptoms cause them. Each question has 5 answer choices ranging from 0-no problem, to 4-big problem. The numerical score for each question are added together, with a minimum score of 0 and a maximum score of 16. A higher score indicates that IC symptoms cause more problems for the patient." (NCT02517996)
Timeframe: Baseline, 2 hours, 2 weeks, 6 weeks, 3 months (Up to 3 months)
| Intervention | score on a scale (Mean) | |||
|---|---|---|---|---|
| Baseline | 2 weeks | 6 weeks | 12 weeks | |
| 1% Lidocaine | 11.75 | 9.71 | 10 | 9.6 |
| Normal Saline | 9.43 | 8.6 | 7.33 | 6 |
2 other studies available for mepivacaine and Hypersensitivity
| Article | Year |
|---|---|
Adjuvant hydrodistension under epidural anesthesia for interstitial cystitis.
Topics: Anesthesia, Epidural; Anesthetics, Local; Collagen Diseases; Cystitis, Interstitial; Dilatation; Fem | 2003 |
Adverse reaction to lidocaine.
Topics: Adolescent; Akathisia, Drug-Induced; Anesthetics, Local; Dizziness; Double-Blind Method; Euphoria; F | 1998 |