mepivacaine has been researched along with Drug Overdose in 12 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The development of safe and effective local anesthetic agents has possibly been the most important advancement in dental science to occur in the last century." | 2.46 | Local anesthetics: pharmacology and toxicity. ( Hersh, EV; Moore, PA, 2010) |
| "5 mL/kg/day, the maximum daily dosage recommended by the U." | 1.46 | Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity. ( Banwell, BL; Corwin, DJ; Osterhoudt, K; Topjian, A, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Corwin, DJ | 1 |
| Topjian, A | 1 |
| Banwell, BL | 1 |
| Osterhoudt, K | 1 |
| Moore, PA | 2 |
| Hersh, EV | 1 |
| Weaver, JM | 1 |
| Feierman, DE | 1 |
| Mahboobi, SK | 1 |
| Milnes, A | 1 |
| Weinberg, G | 1 |
| VadeBoncouer, T | 1 |
| Martínez, MA | 1 |
| Ballesteros, S | 1 |
| Segura, LJ | 1 |
| García, M | 1 |
| Bier, JA | 1 |
| Butterworth, J | 1 |
| James, RL | 1 |
| Grimes, J | 1 |
| Meechan, J | 1 |
| Bruguerolle, B | 1 |
| Emperaire, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intravenous Lidocaine for Postoperative Recovery in Liver Surgery, a Randomized Double Blinded Placebo-controlled Study[NCT05153785] | Phase 2/Phase 3 | 80 participants (Anticipated) | Interventional | 2021-11-15 | Recruiting | ||
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
1 review available for mepivacaine and Drug Overdose
| Article | Year |
|---|---|
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
Local anesthetics: pharmacology and toxicity.
Topics: Anesthesia, Dental; Anesthetics, Local; Bupivacaine; Carticaine; Drug Overdose; Humans; Hydrogen-Ion | 2010 |
11 other studies available for mepivacaine and Drug Overdose
| Article | Year |
|---|---|
Adverse events associated with a large dose of intravenous lipid emulsion for suspected local anesthetic toxicity.
Topics: Anesthetics, Local; Antidotes; Child; Drug Overdose; Fat Emulsions, Intravenous; Female; Humans; Mep | 2017 |
Calculating the maximum recommended dose of local anesthetic.
Topics: Adult; Anesthesia, Dental; Anesthetics, Local; Body Weight; Bupivacaine; Child; Drug Interactions; D | 2007 |
Mepivacaine overdosage is more likely a cause of intraoperative cardiac arrest than drug-drug interaction.
Topics: Drug Interactions; Drug Overdose; Heart Arrest; Humans; Intraoperative Complications; Mepivacaine | 2007 |
Drug-drug interaction or a local anesthetic overdose?
Topics: Anesthetics, Local; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Overdose; Humans; Mepiva | 2007 |
Drug interaction or drug overdose? Supercaine revisited.
Topics: Drug Interactions; Drug Overdose; Heart Arrest; Humans; Intraoperative Complications; Mepivacaine; T | 2007 |
Reporting a fatality during tumescent liposuction.
Topics: Adult; Ambulatory Care; Anesthetics, Local; Drug Overdose; Epilepsy, Tonic-Clonic; Epinephrine; Fata | 2008 |
An abstract error?
Topics: Anesthesia, Dental; Anesthesia, Local; Child; Drug Overdose; Humans; Mepivacaine | 1993 |
Structure-affinity relationships and stereospecificity of several homologous series of local anesthetics for the beta2-adrenergic receptor.
Topics: Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Antagonists; Adult; Alkanes; Amides; Anesthe | 1997 |
How to avoid local anaesthetic toxicity.
Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Body Weight; Child; Child, P | 1998 |
Local anesthetic-induced toxicity may be modified by low doses of flumazenil.
Topics: Anesthesia, Local; Animals; Drug Overdose; Etidocaine; Flumazenil; Lidocaine; Male; Mepivacaine; Mic | 1992 |
Preventing local anesthesia toxicity.
Topics: Anesthesia, Dental; Anesthesia, Local; Body Weight; Child; Drug Overdose; Emergencies; Female; Human | 1992 |