Page last updated: 2024-10-30

mepivacaine and Drug Hypersensitivity

mepivacaine has been researched along with Drug Hypersensitivity in 45 studies

Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.

Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.

Research Excerpts

ExcerptRelevanceReference
"Lidocaine hydrochloride is an amide-type local anesthetic, commonly used for facial plastic as well as other surgical procedures."5.27Anaphylactic reaction to lidocaine. ( Cave, RH; Kennedy, KS, 1986)
"During a routine dental appointment, a patient had an anaphylactic reaction to an injection of a local anesthetic, mepivacaine HCl 3% without a vasoconstrictor."3.66Anaphylaxis due to local anesthesia hypersensitivity: report of case. ( Seskin, L, 1978)
"A 38-year-old white woman developed left medical rectus myositis possibly due to an immune response to mepivacaine (Carbocaine) injected around her upper left first molar."3.66Vertical pendular nystagmus in chronic myositis of medial and lateral rectus. ( Goldberg, RT, 1978)
"Patients with drug allergy show a specific immune response to drugs."1.30Recognition of local anesthetics by alphabeta+ T cells. ( Hari, Y; Pichler, WJ; Schnyder, B; von Greyerz, S; Zanni, MP, 1999)
"In 87 of the 90 patients with suspected anaphylactoid reactions to local anesthetic agents, negative skin reactions to at least one of the agents allowed intrabuccal challenge and subsequent recommendation of an agent for future use."1.29Skin testing after anaphylactoid reactions to dental local anesthetics. A comparison with controls. ( Challacombe, SJ; Hodgson, TA; Shirlaw, PJ, 1993)
"Lidocaine hydrochloride is an amide-type local anesthetic, commonly used for facial plastic as well as other surgical procedures."1.27Anaphylactic reaction to lidocaine. ( Cave, RH; Kennedy, KS, 1986)
"Depression of respiration or total respiratory failure may occur due to blockade of the superficially located medullary chemoreceptors in the form of a high or total spinal block."1.25[Clinical and experimental contribution concerning the pathogenesis of acute life-threatening complications during neck anaesthesia]. ( Egger, G; Steinsiepe, KF; Stofer, AR; Ulrich, L, 1975)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199026 (57.78)18.7374
1990's8 (17.78)18.2507
2000's7 (15.56)29.6817
2010's3 (6.67)24.3611
2020's1 (2.22)2.80

Authors

AuthorsStudies
Selmanoglu, A1
Güvenir, H1
Celik, IK1
Karaatmaca, B1
Toyran, M1
Civelek, E1
Misirlioglu, ED1
Kvisselgaard, AD1
Melchiors, BB1
Krøigaard, M1
Garvey, LH1
Sharma, V1
Harper, NJ1
Garcez, T1
Arkwright, PD1
Estrada, JL1
Perez-Laiz, JL1
Latasa, M1
Rodríguez-Paredes, A1
Hawkins, JM1
Moore, PA1
Cox, B1
Durieux, ME1
Marcus, MA1
Berkun, Y1
Ben-Zvi, A1
Levy, Y1
Galili, D1
Shalit, M1
Valladares Otero, G1
Martínez Navas, A1
Olmedo Granados, L1
Echevarría Moreno, M1
González-Delgado, P1
Antón, R1
Soriano, V1
Zapater, P1
Niveiro, E1
Johnson, WT1
DeStigter, T1
Wahl, G1
Hodgson, TA1
Shirlaw, PJ1
Challacombe, SJ1
Broown, RS1
Redden, RJ1
Chan, JT1
Cuesta-Herranz, J1
de las Heras, M1
Fernández, M1
Lluch, M1
Figueredo, E1
Umpierrez, A1
Lahoz, C1
Bourezane, Y1
Adessi, B1
Didier, JM1
Vuitton, DA1
Laurent, R1
Meechan, J1
Zanni, MP1
von Greyerz, S1
Hari, Y1
Schnyder, B1
Pichler, WJ1
Astarita, C1
Gargano, D1
Romano, C1
Cutajar, M1
Manguso, F1
Montanaro, D1
Napolitano, A1
Pezzuto, F1
Lo Schiavo, M1
Altucci, P1
Abbate, G1
Brown, RS1
Paluvoi, S1
Choksi, S1
Burgess, CM1
Reece, ER1
Seskin, L1
Hiyoshi, K1
Iwanaga, Y1
Kado, K1
Takeda, K1
Goldberg, RT1
Dry, J1
Leynadier, F1
Damecour, C1
Pradalier, A1
Herman, D1
Grimes, DA1
Cates, W1
Weyandt, JA1
Stofer, AR2
Ulrich, L2
Steinsiepe, KF2
Egger, G2
Diaz, PM1
Klein, CE1
Gall, H1
Frigeri, S1
Fiamminghi, L1
Moniaci, D2
Mozzati, M2
Albera, G2
Re, G2
Parabita, SF1
Shimai, N1
Yokoyama, K1
Falace, DA1
Hill, JS1
Kennedy, KS1
Cave, RH1
Sehhati, G1
Frey, R1
Mildner, R1
Smith, RB1
Everett, WG1
Hauck, G2
Petersohn, F1
Henn, R1
Henn, RH1
Schmidt, I1
Aldrete, JA1
O'Higgins, JW1
Ross, NM1
Baumstark, RJ1
Seldin, R1
Rozelle, FR1
Klaschka, F1
Dhunér, KG1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Evaluation of Arrhythmia Mapping With a Globe-Shaped, High-Density, Multi-Electrode Mapping Catheter[NCT05373862]40 participants (Actual)Interventional2022-07-29Completed
Clinical Evaluation of Arrhythmia Mapping With the Multi-Electrode OPTRELL™ Mapping Catheter[NCT04983797]31 participants (Actual)Interventional2021-08-25Completed
Clinical Evaluation of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter[NCT05970120]30 participants (Anticipated)Interventional2023-09-05Recruiting
Assessing the Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage: a Randomized Controlled Trial[NCT03636451]Phase 3114 participants (Actual)Interventional2018-10-29Completed
An Evaluation of the Paracervical Block for Pain Control in First Trimester Surgical Abortion[NCT01094366]Phase 4121 participants (Actual)Interventional2010-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Non-serious Adverse Events Within 7 Days of Index Procedure Associated With the Use of the OPTRELL Catheter

Number of participants with non-serious adverse events within 7 days of index procedure associated with the use of the OPTRELL catheter were reported. An AE is any untoward medical occurrence in a participant participating in a clinical study that does not necessarily have a causal relationship with the pharmaceutical/biological agent under study. (NCT04983797)
Timeframe: Up to 7 days of index procedure at Day 0

InterventionParticipants (Count of Participants)
OPTRELL Mapping Catheter0

Number of Participants With Pre-ablation Mapping and Clinically Indicated Mapping Performed With the OPTRELL Catheter Without Resort to Other Mapping Catheters

Number of participants with pre-ablation mapping and clinically indicated mapping performed with the OPTRELL catheter without resort to other mapping catheters were reported. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
OPTRELL Mapping Catheter31

Number of Participants With SAEs Within 7 Days of Index Procedure

Number of participants with SAEs within 7 days of index procedure were reported. An AE is any untoward medical occurrence in a participant whether or not related to the investigational device. SAE is any AE that results in: death, persistent or significant disability/incapacity, requires inpatient hospitalization or prolongation of existing hospitalization, is life-threatening experience, is a congenital anomaly/birth defect and may jeopardize participant and/or may require medical or surgical intervention to prevent one of the outcomes listed above. (NCT04983797)
Timeframe: Up to 7 days of index procedure at Day 0

InterventionParticipants (Count of Participants)
OPTRELL Mapping Catheter3

Number of Participants With Serious Adverse Events (SAEs) Within 7 Days of Index Procedure Related to the OPTRELL Catheter

Number of participants with SAEs within 7 days of index procedure related to the OPTRELL catheter were reported. An adverse event (AE) is any untoward medical occurrence in a participant whether or not related to the investigational device. SAE is any AE that results in: death, persistent or significant disability/incapacity, requires inpatient hospitalization or prolongation of existing hospitalization, is life-threatening experience, is a congenital anomaly/birth defect and may jeopardize participant and/or may require medical or surgical intervention to prevent one of the outcomes listed above. (NCT04983797)
Timeframe: Up to 7 days of index procedure at Day 0

InterventionParticipants (Count of Participants)
OPTRELL Mapping Catheter0

Number of Responders for Physician Assessment for Ability to Characterize the Tissue

Number of responders for physician assessment for ability to characterize the tissue were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for ability to characterize the tissue. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Compared to the PENTARAY catheter?: Score 1Compared to the PENTARAY catheter?: Score 2Compared to the PENTARAY catheter?: Score 3Compared to the PENTARAY catheter?: Score 4Compared to the PENTARAY catheter?: Score 5Compared to the PENTARAY catheter?: Score 6Compared to the PENTARAY catheter?: Score 7Compared to other competitive multielectrode catheters?: Score 1Compared to other competitive multielectrode catheters?: Score 2Compared to other competitive multielectrode catheters?: Score 3Compared to other competitive multielectrode catheters?: Score 4Compared to other competitive multielectrode catheters?: Score 5Compared to other competitive multielectrode catheters?: Score 6Compared to other competitive multielectrode catheters?: Score 7
OPTRELL Mapping Catheter00000161500000250

Number of Responders for Physician Assessment for Arrhythmogenicity

Number of responders with physician assessment for arrhythmogenicity were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for arrhythmogenicity. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Compared to the PENTARAY catheter?: Score 1Compared to the PENTARAY catheter?: Score 2Compared to the PENTARAY catheter?: Score 3Compared to the PENTARAY catheter?: Score 4Compared to the PENTARAY catheter?: Score 5Compared to the PENTARAY catheter?: Score 6Compared to the PENTARAY catheter?: Score 7Compared to other competitive multielectrode catheters?: Score 1Compared to other competitive multielectrode catheters?: Score 2Compared to other competitive multielectrode catheters?: Score 3Compared to other competitive multielectrode catheters?: Score 4Compared to other competitive multielectrode catheters?: Score 5Compared to other competitive multielectrode catheters?: Score 6Compared to other competitive multielectrode catheters?: Score 7
OPTRELL Mapping Catheter00025101400005191

Number of Responders for Physician Assessment for Catheter Design in OPTRELL Catheter for Mapping

Number of responders for physician assessment for catheter design were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for catheter design in OPTRELL catheter for mapping. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Ability to achieve electrode contact with cardiac tissue: Score 1Ability to achieve electrode contact with cardiac tissue: Score 2Ability to achieve electrode contact with cardiac tissue: Score 3Ability to achieve electrode contact with cardiac tissue: Score 4Ability to achieve electrode contact with cardiac tissue: Score 5Ability to achieve electrode contact with cardiac tissue: Score 6Ability to achieve electrode contact with cardiac tissue: Score 7Electrodes spacing: Score 1Electrodes spacing: Score 2Electrodes spacing: Score 3Electrodes spacing: Score 4Electrodes spacing: Score 5Electrodes spacing: Score 6Electrodes spacing: Score 7Electrode array coverage: Score 1Electrode array coverage: Score 2Electrode array coverage: Score 3Electrode array coverage: Score 4Electrode array coverage: Score 5Electrode array coverage: Score 6Electrode array coverage: Score 7
OPTRELL Mapping Catheter0102218801000131701000921

Number of Responders for Physician Assessment for Catheter Visualization

Number of responders for physician assessment for catheter visualization were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for catheter visualization. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Visualization under fluoroscopy: Score 1Visualization under fluoroscopy: Score 2Visualization under fluoroscopy: Score 3Visualization under fluoroscopy: Score 4Visualization under fluoroscopy: Score 5Visualization under fluoroscopy: Score 6Visualization under fluoroscopy: Score 7Visualization in CARTO 3: Score 1Visualization in CARTO 3: Score 2Visualization in CARTO 3: Score 3Visualization in CARTO 3: Score 4Visualization in CARTO 3: Score 5Visualization in CARTO 3: Score 6Visualization in CARTO 3: Score 7
OPTRELL Mapping Catheter00007915000031018

Number of Responders for Physician Assessment for Catheters Interactions

Number of responders for physician assessment for catheters interactions were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for catheters interactions. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
With CARTO 3 System: Score 1With CARTO 3 System: Score 2With CARTO 3 System: Score 3With CARTO 3 System: Score 4With CARTO 3 System: Score 5With CARTO 3 System: Score 6With CARTO 3 System: Score 7EP Lab recording equipment: Score 1EP Lab recording equipment: Score 2EP Lab recording equipment: Score 3EP Lab recording equipment: Score 4EP Lab recording equipment: Score 5EP Lab recording equipment: Score 6EP Lab recording equipment: Score 7Pacing equipment: Score 1Pacing equipment: Score 2Pacing equipment: Score 3Pacing equipment: Score 4Pacing equipment: Score 5Pacing equipment: Score 6Pacing equipment: Score 7Introducer tool on catheter: Score 1Introducer tool on catheter: Score 2Introducer tool on catheter: Score 3Introducer tool on catheter: Score 4Introducer tool on catheter: Score 5Introducer tool on catheter: Score 6Introducer tool on catheter: Score 7Sheath: Score 1Sheath: Score 2Sheath: Score 3Sheath: Score 4Sheath: Score 5Sheath: Score 6Sheath: Score 7Irrigation bag and tubing: Score 1Irrigation bag and tubing: Score 2Irrigation bag and tubing: Score 3Irrigation bag and tubing: Score 4Irrigation bag and tubing: Score 5Irrigation bag and tubing: Score 6Irrigation bag and tubing: Score 7ICD or other implantable devices: Score 1ICD or other implantable devices: Score 2ICD or other implantable devices: Score 3ICD or other implantable devices: Score 4ICD or other implantable devices: Score 5ICD or other implantable devices: Score 6ICD or other implantable devices: Score 7
OPTRELL Mapping Catheter000041215000181210000043700036148000361480000515110001223

Number of Responders for Physician Assessment for Design and Coverage for Confirming PVI

Number of responders for physician assessment for design and coverage for confirming PVI were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for design and coverage for confirming PVI. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Compared to the PENTARAY catheter?: Score 1Compared to the PENTARAY catheter?: Score 2Compared to the PENTARAY catheter?: Score 3Compared to the PENTARAY catheter?: Score 4Compared to the PENTARAY catheter?: Score 5Compared to the PENTARAY catheter?: Score 6Compared to the PENTARAY catheter?: Score 7Compared to other competitive multielectrode catheters?: Score 1Compared to other competitive multielectrode catheters?: Score 2Compared to other competitive multielectrode catheters?: Score 3Compared to other competitive multielectrode catheters?: Score 4Compared to other competitive multielectrode catheters?: Score 5Compared to other competitive multielectrode catheters?: Score 6Compared to other competitive multielectrode catheters?: Score 7
OPTRELL Mapping Catheter000327900040134

Number of Responders for Physician Assessment for Maneuverability & Handling

Number of responders for physician assessment for maneuverability & handling were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for maneuverability & handling. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Ability to Deploy (Left Atrium): Score 1Ability to Deploy (Left Atrium): Score 2Ability to Deploy (Left Atrium): Score 3Ability to Deploy (Left Atrium): Score 4Ability to Deploy (Left Atrium): Score 5Ability to Deploy (Left Atrium): Score 6Ability to Deploy (Left Atrium): Score 7Ability to Deploy (Right Atrium): Score 1Ability to Deploy (Right Atrium): Score 2Ability to Deploy (Right Atrium): Score 3Ability to Deploy (Right Atrium): Score 4Ability to Deploy (Right Atrium): Score 5Ability to Deploy (Right Atrium): Score 6Ability to Deploy (Right Atrium): Score 7Ability to Deploy (Left Ventricle): Score 1Ability to Deploy (Left Ventricle): Score 2Ability to Deploy (Left Ventricle): Score 3Ability to Deploy (Left Ventricle): Score 4Ability to Deploy (Left Ventricle): Score 5Ability to Deploy (Left Ventricle): Score 6Ability to Deploy (Left Ventricle): Score 7Ability to Deploy (Right Ventricle): Score 1Ability to Deploy (Right Ventricle): Score 2Ability to Deploy (Right Ventricle): Score 3Ability to Deploy (Right Ventricle): Score 4Ability to Deploy (Right Ventricle): Score 5Ability to Deploy (Right Ventricle): Score 6Ability to Deploy (Right Ventricle): Score 7Ability to Maneuver (Left Atrium): Score 1Ability to Maneuver (Left Atrium): Score 2Ability to Maneuver (Left Atrium): Score 3Ability to Maneuver (Left Atrium): Score 4Ability to Maneuver (Left Atrium): Score 5Ability to Maneuver (Left Atrium): Score 6Ability to Maneuver (Left Atrium): Score 7Ability to Maneuver (Right Atrium): Score 1Ability to Maneuver (Right Atrium): Score 2Ability to Maneuver (Right Atrium): Score 3Ability to Maneuver (Right Atrium): Score 4Ability to Maneuver (Right Atrium): Score 5Ability to Maneuver (Right Atrium): Score 6Ability to Maneuver (Right Atrium): Score 7Ability to Maneuver (Left Ventricle): Score 1Ability to Maneuver (Left Ventricle): Score 2Ability to Maneuver (Left Ventricle): Score 3Ability to Maneuver (Left Ventricle): Score 4Ability to Maneuver (Left Ventricle): Score 5Ability to Maneuver (Left Ventricle): Score 6Ability to Maneuver (Left Ventricle): Score 7Ability to Maneuver (Right Ventricle): Score 1Ability to Maneuver (Right Ventricle): Score 2Ability to Maneuver (Right Ventricle): Score 3Ability to Maneuver (Right Ventricle): Score 4Ability to Maneuver (Right Ventricles): Score 5Ability to Maneuver (Right Ventricle): Score 6Ability to Maneuver (Right Ventricle): Score 7Ability to Reach Areas (Left Atrium): Score 1Ability to Reach Areas (Left Atrium): Score 2Ability to Reach Areas (Left Atrium): Score 3Ability to Reach Areas (Left Atrium): Score 4Ability to Reach Areas (Left Atrium): Score 5Ability to Reach Areas (Left Atrium): Score 6Ability to Reach Areas (Left Atrium): Score 7Ability to Reach Areas (Right Atrium): Score 1Ability to Reach Areas (Right Atrium): Score 2Ability to Reach Areas (Right Atrium): Score 3Ability to Reach Areas (Right Atrium): Score 4Ability to Reach Areas (Right Atrium): Score 5Ability to Reach Areas (Right Atrium): Score 6Ability to Reach Areas (Right Atrium): Score 7Ability to Reach Areas (Left Ventricle): Score 1Ability to Reach Areas (Left Ventricle): Score 2Ability to Reach Areas (Left Ventricle): Score 3Ability to Reach Areas (Left Ventricle): Score 4Ability to Reach Areas (Left Ventricle): Score 5Ability to Reach Areas (Left Ventricle): Score 6Ability to Reach Areas (Left Ventricle): Score 7Ability to Reach Areas (Right Ventricle): Score 1Ability to Reach Areas (Right Ventricle): Score 2Ability to Reach Areas (Right Ventricle): Score 3Ability to Reach Areas (Right Ventricle): Score 4Ability to Reach Areas (Right Ventricle): Score 5Ability to Reach Areas (Right Ventricle): Score 6Ability to Reach Areas (Right Ventricle): Score 7Ability to Withdraw (Left Atrium): Score 1Ability to Withdraw (Left Atrium): Score 2Ability to Withdraw (Left Atrium): Score 3Ability to Withdraw (Left Atrium): Score 4Ability to Withdraw (Left Atrium): Score 5Ability to Withdraw (Left Atrium): Score 6Ability to Withdraw (Left Atrium): Score 7Ability to Withdraw (Right Atrium): Score 1Ability to Withdraw (Right Atrium): Score 2Ability to Withdraw (Right Atrium): Score 3Ability to Withdraw (Right Atrium): Score 4Ability to Withdraw (Right Atrium): Score 5Ability to Withdraw (Right Atrium): Score 6Ability to Withdraw (Right Atrium): Score 7Ability to Withdraw (Left Ventricle): Score 1Ability to Withdraw (Left Ventricle): Score 2Ability to Withdraw (Left Ventricle): Score 3Ability to Withdraw (Left Ventricle): Score 4Ability to Withdraw (Left Ventricle): Score 5Ability to Withdraw (Left Ventricle): Score 6Ability to Withdraw (Left Ventricle): Score 7Ability to Withdraw (Right Ventricle): Score 1Ability to Withdraw (Right Ventricle): Score 2Ability to Withdraw (Right Ventricle): Score 3Ability to Withdraw (Right Ventricle): Score 4Ability to Withdraw (Right Ventricle): Score 5Ability to Withdraw (Right Ventricle): Score 6Ability to Withdraw (Right Ventricle): Score 7Insertion/ Withdrawal from Introducer Sheath: Score 1Insertion/ Withdrawal from Introducer Sheath: Score 2Insertion/ Withdrawal from Introducer Sheath: Score 3Insertion/ Withdrawal from Introducer Sheath: Score 4Insertion/ Withdrawal from Introducer Sheath: Score 5Insertion/ Withdrawal from Introducer Sheath: Score 6Insertion/ Withdrawal from Introducer Sheath: Score 7Learning Curve: Score 1Learning Curve: Score 2Learning Curve: Score 3Learning Curve: Score 4Learning Curve: Score 5Learning Curve: Score 6Learning Curve: Score 7
OPTRELL Mapping Catheter00000617000003300031500001000000077900001140005040001000000023126000021300132300001000000008150000042000225000000100012991000044185

Number of Responders for Physician Assessment for Pacing

Number of responders for physician assessment for pacing (local pacing capture) were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for pacing. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Local pacing capture: Score 1Local pacing capture: Score 2Local pacing capture: Score 3Local pacing capture: Score 4Local pacing capture: Score 5Local pacing capture: Score 6Local pacing capture: Score 7
OPTRELL Mapping Catheter0011223

Number of Responders for Physician Assessment for Signal Collection and Quality

Number of responders for physician assessment for signal collection and quality were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for signal collection and quality (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
UNIPOLAR signals in Atrium: Score 1UNIPOLAR signals in Atrium: Score 2UNIPOLAR signals in Atrium: Score 3UNIPOLAR signals in Atrium: Score 4UNIPOLAR signals in Atrium: Score 5UNIPOLAR signals in Atrium: Score 6UNIPOLAR signals in Atrium: Score 7UNIPOLAR signals in Ventricle: Score 1UNIPOLAR signals in Ventricle: Score 2UNIPOLAR signals in Ventricle: Score 3UNIPOLAR signals in Ventricle: Score 4UNIPOLAR signals in Ventricle: Score 5UNIPOLAR signals in Ventricle: Score 6UNIPOLAR signals in Ventricle: Score 7UNIPOLAR noise encountered: Score 1UNIPOLAR noise encountered: Score 2UNIPOLAR noise encountered: Score 3UNIPOLAR noise encountered: Score 4UNIPOLAR noise encountered: Score 5UNIPOLAR noise encountered: Score 6UNIPOLAR noise encountered: Score 7BIPOLAR signals in Atrium: Score 1BIPOLAR signals in Atrium: Score 2BIPOLAR signals in Atrium: Score 3BIPOLAR signals in Atrium: Score 4BIPOLAR signals in Atrium: Score 5BIPOLAR signals in Atrium: Score 6BIPOLAR signals in Atrium: Score 7BIPOLAR signals in Ventricle: Score 1BIPOLAR signals in Ventricle: Score 2BIPOLAR signals in Ventricle: Score 3BIPOLAR signals in Ventricle: Score 4BIPOLAR signals in Ventricle: Score 5BIPOLAR signals in Ventricle: Score 6BIPOLAR signals in Ventricle: Score 7BIPOLAR noise encountered: Score 1BIPOLAR noise encountered: Score 2BIPOLAR noise encountered: Score 3BIPOLAR noise encountered: Score 4BIPOLAR noise encountered: Score 5BIPOLAR noise encountered: Score 6BIPOLAR noise encountered: Score 7
OPTRELL Mapping Catheter000014200013400001474000007160000171000131215

Number of Responders for Physician Assessment for Workflow

Number of responders for physician assessment for workflow were reported. A post-procedure survey of 11 questions, each with individual sub-questions were asked. Each question/sub-question was answered by the physician using a Likert scale of 1 to 7 (1=poor and 7=excellent). Responders refers to participants with physician assessment for workflow. (NCT04983797)
Timeframe: Up to 72 days

InterventionParticipants (Count of Participants)
Ability to reduce fluoroscopy: Score 1Ability to reduce fluoroscopy: Score 2Ability to reduce fluoroscopy: Score 3Ability to reduce fluoroscopy: Score 4Ability to reduce fluoroscopy: Score 5Ability to reduce fluoroscopy: Score 6Ability to reduce fluoroscopy: Score 7Time for pre-procedure mapping: Score 1Time for pre-procedure mapping: Score 2Time for pre-procedure mapping: Score 3Time for pre-procedure mapping: Score 4Time for pre-procedure mapping: Score 5Time for pre-procedure mapping: Score 6Time for pre-procedure mapping: Score 7Time for post-procedure mapping after standard of care ablation: Score 1Time for post-procedure mapping after standard of care ablation: Score 2Time for post-procedure mapping after standard of care ablation: Score 3Time for post-procedure mapping after standard of care ablation: Score 4Time for post-procedure mapping after standard of care ablation: Score 5Time for post-procedure mapping after standard of care ablation: Score 6Time for post-procedure mapping after standard of care ablation: Score 7Ability to identify targets: Score 1Ability to identify targets: Score 2Ability to identify targets: Score 3Ability to identify targets: Score 4Ability to identify targets: Score 5Ability to identify targets: Score 6Ability to identify targets: Score 7
OPTRELL Mapping Catheter000106105000841090002499000101314

Overall Pain

Distance (mm) from the left of the 100-mm Visual Analog Scale (VAS) (reflecting magnitude of pain) recorded after the procedure reflecting the overall pain felt during the procedure. Pain will be assessed using a 100 mm visual analogue scale with the anchors 0 = none, 100 mm = worst imaginable. (NCT03636451)
Timeframe: Once 10 minutes after the procedure on the day of recruitment, approximately one minute.

Interventionunits on a scale (Median)
20cc 1% Lidocaine With 2 Units of Vasopressin Paracervical Block57
40cc Buffered 0.5% Lidocaine With 2 Units of Vasopressin Paracervical Block56

Pain 10 Minutes Post Procedure

Distance (mm) from the left of the 100-mm Visual Analog Scale (VAS) (reflecting magnitude of pain) recorded 10 minutes after the completion of the procedure. Pain will be assessed using a 100 mm visual analogue scale with the anchors 0 = none, 100 mm = worst imaginable. (NCT03636451)
Timeframe: Once 10 minutes after the procedure on the day of recruitment, approximately one minute.

Interventionunits on a scale (Median)
20cc 1% Lidocaine With 2 Units of Vasopressin Paracervical Block26
40cc Buffered 0.5% Lidocaine With 2 Units of Vasopressin Paracervical Block11

Pain With Cervical Dilation

Distance (mm) from the left of the 100-mm Visual Analog Scale (VAS) (reflecting magnitude of pain) recorded at time of cervical dilation. Pain will be assessed using a 100 mm visual analogue scale with the anchors 0 = none, 100 mm = worst imaginable. (NCT03636451)
Timeframe: Once during the procedure on the day of recruitment, approximately one minute. During procedure at time of cervical dilation.

Interventionunits on a scale (Median)
20cc 1% Lidocaine With 2 Units of Vasopressin Paracervical Block52
40cc Buffered 0.5% Lidocaine With 2 Units of Vasopressin Paracervical Block45

Pain With Uterine Aspiration

Distance (mm) from the left of the 100-mm Visual Analog Scale (VAS) (reflecting magnitude of pain) recorded immediately after uterine aspiration. Pain will be assessed using a 100 mm visual analogue scale with the anchors 0 = none, 100 mm = worst imaginable. (NCT03636451)
Timeframe: Once during the procedure on the day of recruitment, approximately 1 minute. During procedure immediately after uterine aspiration.

Interventionunits on a scale (Median)
20cc 1% Lidocaine With 2 Units of Vasopressin Paracervical Block46
40cc Buffered 0.5% Lidocaine With 2 Units of Vasopressin Paracervical Block58

Reviews

3 reviews available for mepivacaine and Drug Hypersensitivity

ArticleYear
Local anesthesia: advances in agents and techniques.
    Dental clinics of North America, 2002, Volume: 46, Issue:4

    Topics: Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Bupivacaine; Carticaine; Chemistry, Pharm

2002
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Toxicity of local anaesthetics.
    Best practice & research. Clinical anaesthesiology, 2003, Volume: 17, Issue:1

    Topics: Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Cocaine; Drug Hypersensitivity; Eti

2003
Physiology and pharmacology of local anesthetic agents.
    International ophthalmology clinics, 1973,Summer, Volume: 13, Issue:2

    Topics: Administration, Topical; Amides; Anesthetics, Local; Animals; Bupivacaine; Cardiovascular System; Ce

1973

Other Studies

42 other studies available for mepivacaine and Drug Hypersensitivity

ArticleYear
Immediate local anesthetic reactions and diagnostic test results in pediatric patients.
    Allergologia et immunopathologia, 2021, Volume: 49, Issue:3

    Topics: Adolescent; Anesthetics, Local; Child; Child, Preschool; Drug Hypersensitivity; Female; Humans; Hype

2021
Lidocaine as a Rare and Hidden Allergen in the Perioperative Setting: A Case Report.
    A&A practice, 2019, Jun-15, Volume: 12, Issue:11

    Topics: Allergens; Drug Hypersensitivity; Drug Interactions; Female; Humans; Lidocaine; Mepivacaine; Middle

2019
Allergic reaction to mepivacaine in a child.
    British journal of anaesthesia, 2013, Volume: 110, Issue:6

    Topics: Adolescent; Anesthetics, Local; Drug Hypersensitivity; Humans; Male; Mepivacaine; Skin Tests

2013
Immediate allergy to mepivacaine.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:6

    Topics: Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Mepivacaine; Middle Aged; Skin Tests

2011
Evaluation of adverse reactions to local anesthetics: experience with 236 patients.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Local; Bupivacaine; Child; Child, Preschool

2003
[Emergency axillary brachial plexus block in a patient allergic to atropine].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:3

    Topics: Atropine; Axilla; Brachial Plexus; Bronchial Spasm; Child; Contraindications; Drug Hypersensitivity;

2006
Cross-reactivity among amide-type local anesthetics in a case of allergy to mepivacaine.
    Journal of investigational allergology & clinical immunology, 2006, Volume: 16, Issue:5

    Topics: Adult; Anesthetics, Local; Cross Reactions; Double-Blind Method; Drug Hypersensitivity; Humans; Immu

2006
Hypersensitivity to procaine, tetracaine, mepivacaine, and methylparaben: report of a case.
    Journal of the American Dental Association (1939), 1983, Volume: 106, Issue:1

    Topics: Anesthesia, Dental; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Mepivacaine; Middle A

1983
[Local anesthesia and Para group allergy].
    Zahnarztliche Praxis, 1983, Aug-12, Volume: 34, Issue:8

    Topics: Anesthetics, Local; Chemical Phenomena; Chemistry; Drug Hypersensitivity; Humans; Lidocaine; Mepivac

1983
Skin testing after anaphylactoid reactions to dental local anesthetics. A comparison with controls.
    Oral surgery, oral medicine, and oral pathology, 1993, Volume: 75, Issue:6

    Topics: Adolescent; Adult; Aged; Anaphylaxis; Anesthesia, Dental; Anesthetics, Local; Chi-Square Distributio

1993
The evaluation of a reported allergic reaction to an amide local anesthetic: a case report.
    Texas dental journal, 1995, Volume: 112, Issue:3

    Topics: Adult; Amides; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Drug Hypersensitivity; Fem

1995
Allergic reaction caused by local anesthetic agents belonging to the amide group.
    The Journal of allergy and clinical immunology, 1997, Volume: 99, Issue:3

    Topics: Adult; Allergens; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Immunoglobulin E; Lidoc

1997
[Immediate allergy to anesthetics of the amide group].
    Gastroenterologie clinique et biologique, 1997, Volume: 21, Issue:4

    Topics: Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Immediate; Mepivacaine;

1997
How to avoid local anaesthetic toxicity.
    British dental journal, 1998, Apr-11, Volume: 184, Issue:7

    Topics: Adult; Aged; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Body Weight; Child; Child, P

1998
Recognition of local anesthetics by alphabeta+ T cells.
    The Journal of investigative dermatology, 1999, Volume: 112, Issue:2

    Topics: Anesthetics, Local; Cell Line; Clone Cells; Cross Reactions; Drug Hypersensitivity; Epitopes; Humans

1999
Long-term absence of sensitization to mepivacaine as assessed by a diagnostic protocol including patch testing.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2001, Volume: 31, Issue:11

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Anesthetics, Local; Child; Drug Hypersensitivity;

2001
Evaluating a dental patient for local anesthesia allergy.
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 2002, Volume: 23, Issue:2

    Topics: Aged; Allergens; Anesthesia, Dental; Anesthetics, Local; Drug Hypersensitivity; Exanthema; Humans; H

2002
Anaphylaxis due to local anesthesia hypersensitivity: report of case.
    Journal of the American Dental Association (1939), 1978, Volume: 96, Issue:5

    Topics: Anaphylaxis; Anesthesia, Dental; Anesthesia, Local; Child; Drug Hypersensitivity; Humans; Male; Mepi

1978
[Allergic reactions caused by mepivacaine (author's transl)].
    Masui. The Japanese journal of anesthesiology, 1978, Volume: 27, Issue:2

    Topics: Aged; Anesthesia, Epidural; Anesthetics, Local; Drug Hypersensitivity; Humans; Male; Mepivacaine

1978
Vertical pendular nystagmus in chronic myositis of medial and lateral rectus.
    Annals of ophthalmology, 1978, Volume: 10, Issue:12

    Topics: Adult; Chronic Disease; Diplopia; Drug Hypersensitivity; Female; Humans; Lidocaine; Mepivacaine; Myo

1978
[Pseudo-anaphylactic reaction to procaine-penicillin G. 3 cases of Hoigne's syndrome].
    La Nouvelle presse medicale, 1976, May-29, Volume: 5, Issue:22

    Topics: Adult; Anxiety; Blood Pressure; Diagnosis, Differential; Drug Hypersensitivity; Female; Hallucinatio

1976
Deaths from paracervical anesthesia used for first-trimester abortion, 1972-1975.
    The New England journal of medicine, 1976, Dec-16, Volume: 295, Issue:25

    Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Obstetrical; Cervix Uteri; Dose-Response Relations

1976
Deaths from paracervical anesthesia used for first-trimester abortion, 1972-1975.
    The New England journal of medicine, 1976, Dec-16, Volume: 295, Issue:25

    Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Obstetrical; Cervix Uteri; Dose-Response Relations

1976
Deaths from paracervical anesthesia used for first-trimester abortion, 1972-1975.
    The New England journal of medicine, 1976, Dec-16, Volume: 295, Issue:25

    Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Obstetrical; Cervix Uteri; Dose-Response Relations

1976
Deaths from paracervical anesthesia used for first-trimester abortion, 1972-1975.
    The New England journal of medicine, 1976, Dec-16, Volume: 295, Issue:25

    Topics: Abortion, Induced; Adolescent; Adult; Anesthesia, Obstetrical; Cervix Uteri; Dose-Response Relations

1976
Hypnosis in a dental patient with allergies.
    The American journal of clinical hypnosis, 1976, Volume: 19, Issue:2

    Topics: Adult; Anesthesia, Intravenous; Dental Care; Drug Hypersensitivity; Female; Humans; Hypnosis, Dental

1976
[Clinical and experimental contribution to the pathogenesis of acute life-threatening incidents following neck anesthesia].
    Schweizerische medizinische Wochenschrift, 1975, Jan-11, Volume: 105, Issue:2

    Topics: Acute Disease; Anaphylaxis; Anesthesia, Epidural; Anesthesia, Local; Anesthetics; Drug Hypersensitiv

1975
Letter: Allergy to procaine and mepivacaine.
    JAMA, 1975, Jan-27, Volume: 231, Issue:4

    Topics: Drug Hypersensitivity; Humans; Injections, Intravenous; Mepivacaine; Procaine

1975
[Clinical and experimental contribution concerning the pathogenesis of acute life-threatening complications during neck anaesthesia].
    Schweizerische medizinische Wochenschrift, 1975, Jan-04, Volume: 105, Issue:1

    Topics: Acute Disease; Aged; Anesthesia, Epidural; Anesthesia, Local; Anesthetics; Animals; Disease Models,

1975
Type IV allergy to amide-type local anesthetics.
    Contact dermatitis, 1991, Volume: 25, Issue:1

    Topics: Anesthetics, Local; Cross Reactions; Drug Hypersensitivity; Female; Humans; Hypersensitivity, Delaye

1991
[Rare complication of local anesthesia].
    Attualita dentale, 1990, Apr-29, Volume: 6, Issue:17

    Topics: Adult; Ampicillin; Anesthesia, Dental; Anesthesia, Local; Drug Hypersensitivity; Female; Humans; Mep

1990
[Allergologic tests: basophil degranulation in odontostomatology. Method and clinical application].
    Minerva stomatologica, 1988, Volume: 37, Issue:12

    Topics: Adult; Aged; Anesthesia, Dental; Anesthetics, Local; Basophils; Child; Drug Hypersensitivity; Female

1988
[Degranulation test of basophils with scalar concentrations of 3% carbocaine. Evaluation of clinical cases with test over 40%].
    Minerva stomatologica, 1989, Volume: 38, Issue:1

    Topics: Adult; Aged; Anesthesia, Dental; Basophils; Drug Hypersensitivity; Female; Humans; Mepivacaine; Midd

1989
[Epidural anaesthesia for multiallergic pregnant patients].
    Masui. The Japanese journal of anesthesiology, 1988, Volume: 37, Issue:6

    Topics: Adult; Anesthesia, Epidural; Drug Hypersensitivity; Female; Humans; Intradermal Tests; Mepivacaine;

1988
Allergy to lidocaine and mepivacaine: report of a case.
    The Compendium of continuing education in dentistry, 1985, Volume: 6, Issue:4

    Topics: Adult; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate; Lidocaine; Male; Mepivacaine

1985
Anaphylactic reaction to lidocaine.
    Archives of otolaryngology--head & neck surgery, 1986, Volume: 112, Issue:6

    Topics: Adult; Anaphylaxis; Bupivacaine; Drug Evaluation; Drug Hypersensitivity; Female; Humans; Intradermal

1986
[Complications of regional anaesthesia and their treatment (author's transl)].
    Munchener medizinische Wochenschrift (1950), 1973, Oct-12, Volume: 115, Issue:41

    Topics: Adrenal Cortex Hormones; Anesthesia, Local; Apnea; Barbiturates; Bradycardia; Bupivacaine; Diagnosis

1973
[Toxicology of scandicaine. I. Chemico-toxicological studies].
    Beitrage zur gerichtlichen Medizin, 1973, Volume: 30

    Topics: Aged; Anesthesia, Local; Anesthetics, Local; Drug Hypersensitivity; Epidermal Cyst; Female; Humans;

1973
[Toxicology of scandicaine. II. Histopathological findings].
    Beitrage zur gerichtlichen Medizin, 1973, Volume: 30

    Topics: Adult; Anesthesia, Local; Anesthetics, Local; Drug Hypersensitivity; Female; Humans; Mepivacaine; Po

1973
Evaluation of patients with history of allergy to local anesthetic drugs.
    Southern medical journal, 1971, Volume: 64, Issue:9

    Topics: Adolescent; Adult; Aged; Anesthetics, Local; Child; Drug Hypersensitivity; Female; Humans; Lidocaine

1971
Serum-type allergic reactions to local anesthetic injections--report of two cases.
    Anesthesia progress, 1966, Volume: 13, Issue:5

    Topics: Anesthesia, Dental; Dentistry; Drug Hypersensitivity; Mepivacaine

1966
Angioneurotic edema. Report of a case of the allergic type caused by sensitivity to mepivacaine hydrochloride.
    Oral surgery, oral medicine, and oral pathology, 1967, Volume: 23, Issue:4

    Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Angioedema; Drug Hypersensitivity; Female; Humans; Mep

1967
Hypersensitive reaction to local anesthesia.
    Texas dental journal, 1968, Volume: 86, Issue:12

    Topics: Anesthesia, Dental; Dentistry; Drug Hypersensitivity; Laryngismus; Mepivacaine

1968
[On the frequency of cosmetic complications].
    Asthetische Medizin, 1968, Aug-20, Volume: 17, Issue:8

    Topics: Accidents, Occupational; Adolescent; Adult; Cosmetics; Drug Hypersensitivity; Female; Humans; Male;

1968
Frequency of general side reactions after regional anaesthesia with mepivacaine.
    Acta anaesthesiologica Scandinavica. Supplementum, 1969, Volume: 37

    Topics: Anesthesia, Conduction; Blood Pressure; Cardiovascular System; Drug Hypersensitivity; Epinephrine; H

1969