mepivacaine has been researched along with Asystole in 15 studies
Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with lipid emulsion extended the time until occurrence of asystole and decreased times to recovery in bupivacaine-induced cardiac toxicity but not in mepivacaine-induced cardiac toxicity compared with control." | 3.80 | Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model. ( Aumeier, C; Busse, H; Graf, BM; Gruber, M; Kasdorf, B; Wiese, CH; Zausig, YA; Zink, W, 2014) |
| "In the isolated rat heart, cardiac arrest was induced by administration of equipotent doses of bupivacaine, ropivacaine, and mepivacaine, respectively, followed by cardiac perfusion with or without lipid emulsion (0." | 1.35 | Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. ( Barwing, J; Graf, BM; Keil, M; Sinner, B; Wiese, CH; Zausig, YA; Zink, W, 2009) |
| "A 61-year-old woman experienced a cardiopulmonary arrest immediately after the retrobulbar injection of a mixture of 2 ml of 0." | 1.26 | Cardiopulmonary arrest after retrobular block. ( Barsoumian, K; May, DR; Rosenblatt, RM, 1980) |
| "The patient died due to cardiac arrest." | 1.25 | [Accident during local anesthesia in a patient with antiarrhythmic therapy]. ( Breithardt, G; Lautenschläger, J; Schulte, HD; Seipel, L, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aumeier, C | 1 |
| Kasdorf, B | 1 |
| Gruber, M | 1 |
| Busse, H | 1 |
| Wiese, CH | 2 |
| Zink, W | 2 |
| Graf, BM | 2 |
| Zausig, YA | 2 |
| Harvey, M | 1 |
| Cave, G | 1 |
| Keil, M | 1 |
| Sinner, B | 1 |
| Barwing, J | 1 |
| Weinberg, G | 3 |
| Warren, L | 1 |
| Chon, JY | 1 |
| Hahn, YJ | 1 |
| Sung, CH | 1 |
| Moon, HS | 1 |
| Schwartz, D | 1 |
| VadeBoncouer, T | 2 |
| Feierman, DE | 1 |
| Mahboobi, SK | 1 |
| Warren, JA | 1 |
| Thoma, RB | 1 |
| Georgescu, A | 1 |
| Shah, SJ | 1 |
| Rosenblatt, RM | 1 |
| May, DR | 1 |
| Barsoumian, K | 1 |
| Breithardt, G | 1 |
| Seipel, L | 1 |
| Schulte, HD | 1 |
| Lautenschläger, J | 1 |
| D'Eramo, EM | 1 |
| Polo, M | 1 |
| Boero, G | 1 |
| Orrù, L | 1 |
| Havers, L | 1 |
| Dudziak, R | 1 |
| Pantke, OA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.[NCT02924454] | Phase 4 | 10 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for mepivacaine and Asystole
| Article | Year |
|---|---|
Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Administration Schedule; Fat Emulsions, Intravenous; | 2014 |
Lipid rescue: does the sink hold water? And other controversies.
Topics: Anesthetics, Local; Animals; Bupivacaine; Emulsions; Epinephrine; Fat Emulsions, Intravenous; Female | 2014 |
Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest.
Topics: Amides; Anesthetics, Local; Animals; Antidotes; Bupivacaine; Fat Emulsions, Intravenous; Heart Arres | 2009 |
Lipid resuscitation: listening to our patients and learning from our models.
Topics: Amides; Anesthetics, Local; Animals; Antipsychotic Agents; Benzodiazepines; Bupivacaine; Epinephrine | 2012 |
Amnesia and pain relief after cardiopulmonary resuscitation in a cancer pain patient: a case report.
Topics: Amnesia; Anesthesia, Local; Bone Neoplasms; Breast Neoplasms; Cardiopulmonary Resuscitation; Electro | 2012 |
Was case report a case of unrecognized local anesthetic toxicity?
Topics: Adrenergic beta-Antagonists; Adult; Anesthetics, Local; Bupivacaine; Female; Heart Arrest; Humans; L | 2003 |
Mepivacaine overdosage is more likely a cause of intraoperative cardiac arrest than drug-drug interaction.
Topics: Drug Interactions; Drug Overdose; Heart Arrest; Humans; Intraoperative Complications; Mepivacaine | 2007 |
Drug interaction or drug overdose? Supercaine revisited.
Topics: Drug Interactions; Drug Overdose; Heart Arrest; Humans; Intraoperative Complications; Mepivacaine; T | 2007 |
Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block.
Topics: Anesthetics, Local; Brachial Plexus; Bupivacaine; Cardiopulmonary Resuscitation; Electrocardiography | 2008 |
Cardiopulmonary arrest after retrobular block.
Topics: Anesthetics, Local; Bupivacaine; Drug Combinations; Female; Heart Arrest; Humans; Hyaluronoglucosami | 1980 |
[Accident during local anesthesia in a patient with antiarrhythmic therapy].
Topics: Adolescent; Anesthesia, Local; Aprindine; Cardiac Complexes, Premature; Cardiomyopathies; Drug Inter | 1975 |
Morbidity and mortality with outpatient anesthesia: the Massachusetts experience.
Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intraveno | 1992 |
[Brief considerations on complications of local anesthetics. (Apropos of 3 treated cases)].
Topics: Anesthesia, Local; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Child; Child, Preschool; Drainage | 1968 |
[203. The dangers of local anesthesia].
Topics: Adult; Anesthetics, Local; Epinephrine; Female; Heart Arrest; Humans; Infant; Lidocaine; Male; Mepiv | 1967 |
[Effect of d,1-N-methylhexahydropicolinyl-2,6-dimethylanilide HCl (Mepivaeaine) on the oxygen consumption and coronary flow of the isolated rat heart].
Topics: Animals; Blood Flow Velocity; Coronary Vessels; Depression, Chemical; Heart Arrest; In Vitro Techniq | 1967 |