Page last updated: 2024-10-30

mepivacaine and Asystole

mepivacaine has been researched along with Asystole in 15 studies

Mepivacaine: A local anesthetic that is chemically related to BUPIVACAINE but pharmacologically related to LIDOCAINE. It is indicated for infiltration, nerve block, and epidural anesthesia. Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
mepivacaine : A piperidinecarboxamide in which N-methylpipecolic acid and 2,6-dimethylaniline have combined to form the amide bond. It is used as a local amide-type anaesthetic.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with lipid emulsion extended the time until occurrence of asystole and decreased times to recovery in bupivacaine-induced cardiac toxicity but not in mepivacaine-induced cardiac toxicity compared with control."3.80Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model. ( Aumeier, C; Busse, H; Graf, BM; Gruber, M; Kasdorf, B; Wiese, CH; Zausig, YA; Zink, W, 2014)
"In the isolated rat heart, cardiac arrest was induced by administration of equipotent doses of bupivacaine, ropivacaine, and mepivacaine, respectively, followed by cardiac perfusion with or without lipid emulsion (0."1.35Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest. ( Barwing, J; Graf, BM; Keil, M; Sinner, B; Wiese, CH; Zausig, YA; Zink, W, 2009)
"A 61-year-old woman experienced a cardiopulmonary arrest immediately after the retrobulbar injection of a mixture of 2 ml of 0."1.26Cardiopulmonary arrest after retrobular block. ( Barsoumian, K; May, DR; Rosenblatt, RM, 1980)
"The patient died due to cardiac arrest."1.25[Accident during local anesthesia in a patient with antiarrhythmic therapy]. ( Breithardt, G; Lautenschläger, J; Schulte, HD; Seipel, L, 1975)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19905 (33.33)18.7374
1990's1 (6.67)18.2507
2000's5 (33.33)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aumeier, C1
Kasdorf, B1
Gruber, M1
Busse, H1
Wiese, CH2
Zink, W2
Graf, BM2
Zausig, YA2
Harvey, M1
Cave, G1
Keil, M1
Sinner, B1
Barwing, J1
Weinberg, G3
Warren, L1
Chon, JY1
Hahn, YJ1
Sung, CH1
Moon, HS1
Schwartz, D1
VadeBoncouer, T2
Feierman, DE1
Mahboobi, SK1
Warren, JA1
Thoma, RB1
Georgescu, A1
Shah, SJ1
Rosenblatt, RM1
May, DR1
Barsoumian, K1
Breithardt, G1
Seipel, L1
Schulte, HD1
Lautenschläger, J1
D'Eramo, EM1
Polo, M1
Boero, G1
Orrù, L1
Havers, L1
Dudziak, R1
Pantke, OA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.[NCT02924454]Phase 410 participants (Actual)Interventional2016-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

15 other studies available for mepivacaine and Asystole

ArticleYear
Lipid emulsion pretreatment has different effects on mepivacaine and bupivacaine cardiac toxicity in an isolated rat heart model.
    British journal of anaesthesia, 2014, Volume: 112, Issue:4

    Topics: Anesthetics, Local; Animals; Bupivacaine; Drug Administration Schedule; Fat Emulsions, Intravenous;

2014
Lipid rescue: does the sink hold water? And other controversies.
    British journal of anaesthesia, 2014, Volume: 112, Issue:4

    Topics: Anesthetics, Local; Animals; Bupivacaine; Emulsions; Epinephrine; Fat Emulsions, Intravenous; Female

2014
Lipid emulsion improves recovery from bupivacaine-induced cardiac arrest, but not from ropivacaine- or mepivacaine-induced cardiac arrest.
    Anesthesia and analgesia, 2009, Volume: 109, Issue:4

    Topics: Amides; Anesthetics, Local; Animals; Antidotes; Bupivacaine; Fat Emulsions, Intravenous; Heart Arres

2009
Lipid resuscitation: listening to our patients and learning from our models.
    Anesthesia and analgesia, 2012, Volume: 114, Issue:4

    Topics: Amides; Anesthetics, Local; Animals; Antipsychotic Agents; Benzodiazepines; Bupivacaine; Epinephrine

2012
Amnesia and pain relief after cardiopulmonary resuscitation in a cancer pain patient: a case report.
    Journal of Korean medical science, 2012, Volume: 27, Issue:6

    Topics: Amnesia; Anesthesia, Local; Bone Neoplasms; Breast Neoplasms; Cardiopulmonary Resuscitation; Electro

2012
Was case report a case of unrecognized local anesthetic toxicity?
    Anesthesia and analgesia, 2003, Volume: 96, Issue:6

    Topics: Adrenergic beta-Antagonists; Adult; Anesthetics, Local; Bupivacaine; Female; Heart Arrest; Humans; L

2003
Mepivacaine overdosage is more likely a cause of intraoperative cardiac arrest than drug-drug interaction.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:5

    Topics: Drug Interactions; Drug Overdose; Heart Arrest; Humans; Intraoperative Complications; Mepivacaine

2007
Drug interaction or drug overdose? Supercaine revisited.
    Anesthesia and analgesia, 2007, Volume: 105, Issue:2

    Topics: Drug Interactions; Drug Overdose; Heart Arrest; Humans; Intraoperative Complications; Mepivacaine; T

2007
Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:5

    Topics: Anesthetics, Local; Brachial Plexus; Bupivacaine; Cardiopulmonary Resuscitation; Electrocardiography

2008
Cardiopulmonary arrest after retrobular block.
    American journal of ophthalmology, 1980, Volume: 90, Issue:3

    Topics: Anesthetics, Local; Bupivacaine; Drug Combinations; Female; Heart Arrest; Humans; Hyaluronoglucosami

1980
[Accident during local anesthesia in a patient with antiarrhythmic therapy].
    Zeitschrift fur Kardiologie, 1975, Volume: 64, Issue:7

    Topics: Adolescent; Anesthesia, Local; Aprindine; Cardiac Complexes, Premature; Cardiomyopathies; Drug Inter

1975
Morbidity and mortality with outpatient anesthesia: the Massachusetts experience.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1992, Volume: 50, Issue:7

    Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intraveno

1992
[Brief considerations on complications of local anesthetics. (Apropos of 3 treated cases)].
    Acta anaesthesiologica, 1968, Volume: 19

    Topics: Anesthesia, Local; Bronchial Neoplasms; Carcinoma, Adenoid Cystic; Child; Child, Preschool; Drainage

1968
[203. The dangers of local anesthesia].
    Langenbecks Archiv fur Chirurgie, 1967, Volume: 319

    Topics: Adult; Anesthetics, Local; Epinephrine; Female; Heart Arrest; Humans; Infant; Lidocaine; Male; Mepiv

1967
[Effect of d,1-N-methylhexahydropicolinyl-2,6-dimethylanilide HCl (Mepivaeaine) on the oxygen consumption and coronary flow of the isolated rat heart].
    Arzneimittel-Forschung, 1967, Volume: 17, Issue:12

    Topics: Animals; Blood Flow Velocity; Coronary Vessels; Depression, Chemical; Heart Arrest; In Vitro Techniq

1967