mephenytoin has been researched along with Stevens-Johnson Syndrome in 3 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Observations of Lyell's syndrome in two girls, one 2 and the other 7 years of age, investigated serologically, histologically and by immunofluorescent technique, are reported." | 1.26 | Lyell's syndrome: histological, immunohistochemical and serological observations. ( Babala, J; Blazovsky, J; Brozman, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pollack, MA | 1 |
| Burk, PG | 1 |
| Nathanson, G | 1 |
| Nozicková, M | 1 |
| Danda, J | 1 |
| Hamáková, K | 1 |
| Kraus, Z | 1 |
| Babala, J | 1 |
| Brozman, M | 1 |
| Blazovsky, J | 1 |
3 other studies available for mephenytoin and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Mucocutaneous eruptions due to antiepileptic drug therapy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Erythema Multiforme; Female; Humans; Male; | 1979 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
Lyell's syndrome: histological, immunohistochemical and serological observations.
Topics: Anti-Bacterial Agents; Antibodies; Antibody Formation; Aspirin; Child; Child, Preschool; Female; Hum | 1976 |