mephenytoin has been researched along with Seizures in 11 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A new syndrome, paradoxical intoxication, has been defined in which high levels of hydantoins, and in one instance carbamazepine, produced an increase in seizures with little or no evidence of intoxication; a decrease in these levels produced an improvement in seizure control." | 3.65 | Paradoxical intoxication--a complication of anticonvulsant administration. ( Ojemann, LM; Troupin, AS, 1975) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| " In order to test the validity of FEAD as an absence seizure model, the present experiments determined dose-response relationships for the suppression of FEAD by six antiepileptic drugs with established clinical profiles." | 1.26 | Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs. ( Burnham, WM; King, GA; Livingston, KE, 1980) |
| "Drug-induced systemic lupus erythematosus (SLE)-like syndromes in children are most commonly associated with the administration of ethosuximide, diphenylhydantoin, and trimethadione." | 1.26 | Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants. ( Fishman, L; Hanson, V; Singsen, BH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wolfe, JF | 1 |
| Rathman, TL | 1 |
| Sleevi, MC | 1 |
| Campbell, JA | 1 |
| Greenwood, TD | 1 |
| WONG, YT | 1 |
| HAYS, AL | 1 |
| HILL, TS | 1 |
| JESSERER, H | 1 |
| RUSKIN, DB | 1 |
| LITTLJOHN, WS | 1 |
| LITTLE, SC | 1 |
| McLALLEN, CD | 1 |
| Sklenovský, A | 1 |
| Chmela, Z | 1 |
| King, GA | 1 |
| Burnham, WM | 1 |
| Livingston, KE | 1 |
| Boothe, DM | 1 |
| Singsen, BH | 1 |
| Fishman, L | 1 |
| Hanson, V | 1 |
| Troupin, AS | 1 |
| Ojemann, LM | 1 |
1 review available for mephenytoin and Seizures
| Article | Year |
|---|---|
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
10 other studies available for mephenytoin and Seizures
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of some new 2-substituted 3-aryl-4(3H)-quinazolinones.
Topics: Animals; Anticonvulsants; Bicuculline; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; | 1990 |
The control with mesantoin on convulsive seizures due to neurosyphilis; clinical and electroencephalographic studies.
Topics: Electroencephalography; Epilepsy; Humans; Hydantoins; Mephenytoin; Neurosyphilis; Seizures | 1952 |
[Differentiation of methylphenylethylhydantoin's (mesantoin's) mode of action in epileptic and in tetanic convulsions].
Topics: Epilepsy; Humans; Hydantoins; Mephenytoin; Seizures; Tetany | 1950 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
Mesantoin in the treatment of convulsive disorders.
Topics: Epilepsy; Hydantoins; Mephenytoin; Seizures | 1951 |
The effect of antiepileptic drugs on nonesterified fatty acids in the brain structures during convulsive state.
Topics: Animals; Anticonvulsants; Bemegride; Brain; Diazepam; Drug Evaluation, Preclinical; Fatty Acids, Non | 1984 |
Flash-evoked afterdischarge in rat as a model of the absence seizure: dose-response studies with therapeutic drugs.
Topics: Acetazolamide; Animals; Dose-Response Relationship, Drug; Ethosuximide; Evoked Potentials; Male; Mep | 1980 |
Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants.
Topics: Adolescent; Adult; Antibodies, Antinuclear; Anticonvulsants; Child; Child, Preschool; Ethosuximide; | 1976 |
Anticonvulsant osteomalacia.
Topics: Adolescent; Anticonvulsants; Bone and Bones; Humans; Male; Mephenytoin; Minerals; Osteomalacia; Phen | 1975 |
Paradoxical intoxication--a complication of anticonvulsant administration.
Topics: Carbamazepine; Drug Therapy, Combination; Humans; Hydantoins; Mephenytoin; Phenytoin; Seizures | 1975 |