mephenytoin has been researched along with Hepatitis, Chronic in 1 studies
Mephenytoin: An anticonvulsant effective in tonic-clonic epilepsy (EPILEPSY, TONIC-CLONIC). It may cause blood dyscrasias.
mephenytoin : An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Hepatitis, Chronic: INFLAMMATION of the LIVER with ongoing hepatocellular injury for 6 months or more, characterized by NECROSIS of HEPATOCYTES and inflammatory cell (LEUKOCYTES) infiltration. Chronic hepatitis can be caused by viruses, medications, autoimmune diseases, and other unknown factors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " An alternative approach is to measure the hepatic metabolism of a highly extracted compound whose oral clearance and systemic bioavailability are dependent on both hepatocyte function and degree of portosystemic shunt." | 1.30 | Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis. ( Adedoyin, A; Arns, PA; Branch, RA; DiBisceglie, AM; Hoofnagle, JH; Waggoner, JG; Wilkinson, GR, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arns, PA | 1 |
| Adedoyin, A | 1 |
| DiBisceglie, AM | 1 |
| Waggoner, JG | 1 |
| Hoofnagle, JH | 1 |
| Wilkinson, GR | 1 |
| Branch, RA | 1 |
1 other study available for mephenytoin and Hepatitis, Chronic
| Article | Year |
|---|---|
Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis.
Topics: Adult; Analysis of Variance; Anticonvulsants; Biological Availability; Glycocholic Acid; Hepatitis, | 1997 |